Abstract:
:The purpose of this study was to investigate the antioxidant activities of short-neck clam water extract (SNC-WE) enriched in taurine. In the present study, the half-maximal inhibitory concentration (IC50) values of the SNC-WE for DPPH, superoxide, and alkyl radical scavenging activities determined by an electron spin resonance (ESR) spectrometer were 3.16, 1.54 and 0.58 mg/mL, respectively. Furthermore, we evaluated the inhibitory effect of taurine enriched SNC-WE against the oxidative stress induced by 2,2'-azobis dihydrochloride (AAPH) in zebrafish embryos. In the present study, we observed that taurine enriched SNC-WE significantly suppressed reactive oxygen species (ROS) production, lipid peroxidation as well as cell death in the zebrafish model. These results indicate that taurine enriched SNC-WE might have antioxidant effects in both in vitro and in vivo zebrafish model.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Lee DS,Lee SH,Jeon YJ,Cheong SHdoi
10.1007/978-94-024-1079-2_82subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1035-1046eissn
0065-2598issn
2214-8019journal_volume
975 Pt 2pub_type
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