Abstract:
:Retbindin (Rtbdn) is a novel protein of unknown function found exclusively in the retina. Recently, our group has suggested, from in silico analysis of the peptide sequence and in vitro binding data, that Rtbdn could function to bind riboflavin (RF) and its derivatives flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), collectively known as flavins. Here we confirm that Rtbdn is capable of flavin binding and that this characteristic can protect photoreceptors from flavin-sensitized light damage.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Kelley RA,Al-Ubaidi MR,Naash MIdoi
10.1007/978-3-319-75402-4_60subject
Has Abstractpub_date
2018-01-01 00:00:00pages
485-490eissn
0065-2598issn
2214-8019journal_volume
1074pub_type
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