Abstract：
:In hospitals, human milk is subjected to heat treatment to reduce risk of transmission of infectious agents such as human immunodeficiency virus (HIV), hepatitis B, cytomegalovirus, and bacterial contamination, especially during feeding of banked milk to preterm infants. Fat losses due to heat treatment have been extensively studied in cow milk but have received little attention in human milk. We studied the effect of human milk pasteurization and sterilization on total fat content available to the infant as well as on fatty acid composition. Milk samples from 12 mothers (days 5-35 of lactation) were divided into three equal parts: one remained fresh, one was pasteurized (62.5 degrees C for 30min), and one was sterilized (120 degrees C for 30min). Fat content was determined gravimetrically, and the contribution of 30 fatty acids was determined by gas chromatography. For investigation of loss of available fat in sterilized milk, milk was collected from two additional mothers and analyzed with a modified extraction method. Total fat content was the same in fresh, pasteurized, and sterilized milk. The available fat content was 3.1+/-0.4g/dL (mean +/- SE) in fresh human milk, 3.1+/-0.4g/dL in pasteurized human milk, and 2.7+/-0.3g/dL (P < 0.001 vs. fresh) in sterilized human milk because of formation of a surface skin and fat adherence to the vial wall after sterilization. The fatty acid composition of 10 saturated, 10 monounsaturated, and 10 polyunsaturated fatty acids of both the n6 and n3 series was not affected by pasteurization. In sterilized milk there was a slight decrease of linoleic acid (C18:2n6; -0.7% vs. fresh; P = 0.006) and arachidonic acid (C20:4n6; -2.5%; P = 0.045). Pasteurization and sterilization do not affect total fat content of human milk, but sterilization may reduce available fat content by >10%. Fatty acid composition of human milk is not changed by pasteurization, but is slightly changed by sterilization.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Fidler N,Sauerwald TU,Demmelmair H,Koletzko Bdoi
10.1007/978-1-4615-1371-1_60subject
Has Abstractpub_date
2001-01-01 00:00:00pages
485-95eissn
0065-2598issn
2214-8019journal_volume
501pub_type
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