Abstract:
:Heparan sulphate (HS) is a linear glycosaminoglycan found ubiquitously on the surface and in the pericellular matrix of metazoan cells that is covalently attached to core proteins to form HS proteoglycans. HS interacts specifically with a large number (> 100) of extracellular regulatory proteins, many of which are key players in mammary development and function. HS thus acts a receptor, in which capacity it regulates the bioavailability, localisation and activity of these regulatory proteins.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Bateman KL,Delehedde M,Sergeant N,Wartelle I,Vidyasagar R,Fernig DGdoi
10.1007/0-306-46832-8_7subject
Has Abstractpub_date
2000-01-01 00:00:00pages
65-9eissn
0065-2598issn
2214-8019journal_volume
480pub_type
杂志文章,评审abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. Loss-of-function mutations in the gene encoding PARK7/DJ-1 were identified in familial PD. Wild-type DJ-1 acts as an oxidative stress sensor in ...
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更新日期:2020-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
abstract::Hypertension increases the risks of end-organ injury, maternal/fetal vulnerability, and total mortality. Throughout the world, it kills about 7.5 million people every year. During 1975-2015, the number of adults with hypertension increased from 594 million to more than 1.1 billion, mostly due to the increase in the lo...
journal_title:Advances in experimental medicine and biology
pub_type:
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
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doi:10.1007/978-1-4899-7678-9_6
更新日期:2016-01-01 00:00:00
abstract::Addiction is marked by repeating a certain behavior while ignoring the potential physical or mental consequences. Non-substance addiction provides an ideal model for researching the emergence and development of addiction's basic mechanism. Comparative studies of substance and non-substance addiction are helpful to rev...
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abstract::Mycotoxins are secondary metabolites produced by a wide variety of fungal species that contaminate food or feed. Fumonisins (FUM), deoxynivalenol (DON) and zearalenone (ZEN) are examples of common mycotoxins in grains that have been shown to affect human and/or animal health. Physical, chemical and biological methods ...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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abstract::Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms. Epigenetic modifications, suc...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-53889-1_13
更新日期:2017-01-01 00:00:00
abstract::A common characteristic among fungal pathogens of plants is that each specializes on a narrow range of specific plants as hosts. One adaptation to a specific host plant is the recognition of the host's chemicals which can be used to trigger genes or developmental pathways needed for pathogenesis. The production of cha...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4757-5235-9_2
更新日期:2002-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 临床试验,杂志文章
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abstract::The intramural blood vessels and fluid-filled interstitial space form a hydraulic continuum enmeshed by myocardial muscle layers and collagen matrix. Coronary circulation was found to be strongly influenced by passive and active properties of the muscle surrounding the coronary microvasculature. Selective remodeling o...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-2946-0_11
更新日期:1993-01-01 00:00:00
abstract::Proteoglycans consist of a protein core to which at least one glycosaminoglycan chain is attached. They play important roles in the physiology and biomechanical function of tendons, ligaments and cardiovascular system through their involvement in regulation of assembly and maintenance of extracellular matrix, and as t...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-94-007-7893-1_4
更新日期:2014-01-01 00:00:00
abstract::We address here aspects of the implementation of a memory evolutive system (MES), based on the model proposed by A. Ehresmann and J. Vanbremeersch (2007), by means of a simulated network of spiking neurons with time dependent plasticity. We point out the advantages and challenges of applying category theory for the re...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-0-387-79100-5_2
更新日期:2010-01-01 00:00:00
abstract::The rotaviruses are important medical and veterinary pathogens that cause acute diarrheal disease in children and in the young of most mammalian and avian species. The successful development of a rotavirus vaccine should significantly reduce worldwide infant morbidity and mortality and economic losses and increase foo...
journal_title:Advances in experimental medicine and biology
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abstract::Parathion is a widely used organophosphoric pesticide which has also been reported to interfere with mouse spermatogenesis. Moreover it has been related to prenatal toxicity in mammals. Sixteen A/ Snell mice were sacrificed at day 17 of pregnancy. Testes and epididymides of the male fetuses were implanted in the allan...
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abstract::Direct studies linking drugs of abuse with changes in neurotransmitters and subsequent effects on the immune system are not abundant. One can, however, hypothesize that an indirect effect can occur since a variety of neurotransmitters known to be acted on by various drugs of abuse can, in turn, be correlated with chan...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4684-5925-8_2
更新日期:1991-01-01 00:00:00
abstract::In this study, we explored the effect of three lactic acid bacteria (LAB), i.e. Enterococcus sp CM9, Enterococcus sp CM18 and Enterococcus faecium H3, and their supernatants, on seven biofilm-forming pathogenic strains isolated from human urinary tract or nose infections. By quantitative biofilm production assay, a st...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::After the initial discovery of neuropilin-1 as an epitope on axons recognized by a monoclonal antibody, neuropilins were rediscovered in the search for receptors mediating the repulsive actions of class 3 Semaphorins, notably Sema3A. Neuropilins are the ligand binding moieties in the class 3 Semaphorin receptor comple...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract::Recently, a role for SUMO modification outside of the nucleus has emerged. Although the number of extranuclear proteins known to be sumoylated is comparatively small, ion channels represent one important new class of these proteins. Ion channels are responsible for the control of membrane excitability and therefore ar...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Tetrahydropapaveroline, the tetrahydroisoquinoline alkaloid derived from dopamine, is converted in vivo by rats and by rat liver and brain preparations to tetrahydroprotoberberine alkaloids. The latter alkaloids have also been identified for the first time in the urine of parkinsonian patients receiving L-dopa therapy...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4757-0632-1_6
更新日期:1975-01-01 00:00:00
abstract::Stem cells having the capability to differentiate into other type of cells and renewing themselves, gained so much importance in recent years. Investigations in stem cells revealed that mesenchymal stem cells can successfully differentiate into other type of cells like adipocytes, hepatocytes, osteocytes, neurocytes a...
journal_title:Advances in experimental medicine and biology
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更新日期:2020-01-01 00:00:00
abstract::Recent advances in regenerative medicine and cell-based therapy are bringing promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive sour...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::In the visible/NIR (600-900 nm) three different redox centres are potentially detectable in vivo in mitochondrial cytochrome c oxidase: haem a (605nm), the binuclear haem a3/CuB centre (655 nm) and CuA (830 nm). In this paper we report changes in the steady state reduction of these centres following increases in the r...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::Cyclopiazonic acid (CPA) is a toxic indole tetramic acid that has been isolated from numerous species of Aspergillus and Penicillium. It has been found as a natural contaminant of cheese, corn, peanuts and various feedstuffs. Historically, thin-layer chromatography has been the most widely used method for quantitative...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-1-4615-0629-4_11
更新日期:2002-01-01 00:00:00