Neural growth, neural damage and neurotrophins in the kindling model of epilepsy.

Abstract:

:Do seizures change the brain? Studies on the kindling model--a widely used animal model of epilepsy--suggest that they do. Dr. Racine, one of the pioneers in the kindling field, describes the basic phenomena of kindling, and discusses the possible roles of cell growth and cell death in this model.

journal_name

Adv Exp Med Biol

authors

Racine RJ,Adams B,Osehobo P,Fahnestock M

doi

10.1007/978-1-4615-1335-3_16

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

149-70

eissn

0065-2598

issn

2214-8019

journal_volume

497

pub_type

杂志文章,评审
  • The effects of dietary taurine supplementation on plasma and liver lipid in ovariectomized rats.

    abstract::The purpose of this study was to investigate the effect of dietary taurine supplementation on plasma and liver lipid content in ovariectomized (OVX) rats. Forty female Sprague-Dawley rats were divided into two groups, one that was OVX and the other sham operated (Sham). They were further divided into either control or...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-0-387-75681-3_40

    authors: Choi MJ,Chang KJ

    更新日期:2009-01-01 00:00:00

  • Nanostructured, Self-Assembled Spider Silk Materials for Biomedical Applications.

    abstract::The extraordinary mechanical properties of spider silk fibers result from the interplay of composition, structure and self-assembly of spider silk proteins (spidroins). Genetic approaches enabled the biotechnological production of recombinant spidroins which have been employed to unravel the self-assembly and spinning...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-981-13-9791-2_6

    authors: Humenik M,Pawar K,Scheibel T

    更新日期:2019-01-01 00:00:00

  • Toward a theory of multilevel evolution: long-term information integration shapes the mutational landscape and enhances evolvability.

    abstract::Most of evolutionary theory has abstracted away from how information is coded in the genome and how this information is transformed into traits on which selection takes place. While in the earliest stages of biological evolution, in the RNA world, the mapping from the genotype into function was largely predefined by t...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4614-3567-9_10

    authors: Hogeweg P

    更新日期:2012-01-01 00:00:00

  • A preliminary survey of antibiotic resistance of Salmonella in market-age swine.

    abstract::We conducted an epidemiological survey of antibiotic resistance in Salmonella recovered from market-age swine at five different Texas farms. These farms, which were visited between October 1997 and June 1998, were completely integrated, farrow-to-finish operations. Samples were taken from the lymph nodes and cecal con...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4143-1_31

    authors: Farrington LA,Harvey RB,Buckley SA,Stanker LH,Inskip PD

    更新日期:1999-01-01 00:00:00

  • Perspectives on the state of insect transgenics.

    abstract::Genetic transformation is a critical component to the fundamental genetic analysis of insect species and holds great promise for establishing strains that improve population control and behavior for practical application. This is especially so for insects that are disease vectors, many of which are currently subject t...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-0-387-78225-6_1

    authors: O'Brochta DA,Handler AM

    更新日期:2008-01-01 00:00:00

  • Enteric neuropathies: Yesterday, Today and Tomorrow.

    abstract::Enteric neuropathy is a term indicating an impairment of the innervation supplying the gastrointestinal tract. The clinical phenotypes of the enteric neuropathies are the 'tip of the iceberg' of severe functional digestive diseases, such as intestinal pseudo-obstruction syndromes (e.g., chronic intestinal pseudo-obstr...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-27592-5_12

    authors: De Giorgio R,Bianco F,Latorre R,Caio G,Clavenzani P,Bonora E

    更新日期:2016-01-01 00:00:00

  • Effects of revascularisation on evoked cerebral blood oxygenation responses in stroke patients.

    abstract::We demonstrated that ischemic strokes exhibit an increase of deoxyhemoglobin during activation. We evaluated the effect of revascu-larization on the abnormal evoked cerebral blood oxygenation (CBO) re-sponses in these patients, employing near-infrared spectroscopy (NIRS). We selected five patients who exhibited an inc...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-1241-1_76

    authors: Nakamura S,Sakatani K,Kano T,Hoshino T,Fujiwara N,Murata Y,Katayama Y

    更新日期:2010-01-01 00:00:00

  • The zona pellucida "receptors".

    abstract::Binding of mammalian sperm to the zona pellucida and the induction of the acrosome reaction are prerequisites for successful oocyte fertilization. In the mouse model, the zona pellucida consists of three sulfated glycoproteins, ZP1, ZP2, and ZP3. Zona pellucida proteins are secreted to form a filamentous zona matrix i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:

    authors: Hinsch E,Hägele W,Schill WB,Hinsch KD

    更新日期:1997-01-01 00:00:00

  • Stochasticity and determinism in models of hematopoiesis.

    abstract::This chapter represents a novel view of modeling in hematopoiesis, synthesizing both deterministic and stochastic approaches. Whereas the stochastic models work in situations where chance dominates, for example when the number of cells is small, or under random mutations, the deterministic models are more important fo...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4939-2095-2_7

    authors: Kimmel M

    更新日期:2014-01-01 00:00:00

  • Urinary diversion in the management of chronic perineal skin ulceration in spinal cord injured patients following sphincterotomy.

    abstract::Carefully tailored urinary diversion offers an excellent alternative in the spinal cord injured patient with chronic urine leakage and pressure sores following sphincterotomy. ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-8889-8_55

    authors: Hansen M,Terris MK

    更新日期:2003-01-01 00:00:00

  • Transmissible gastroenteritis coronavirus carrier sow.

    abstract::A sow infected with virulent transmissible gastroenteritis virus (TGEV) shed virulent virus in her feces for 18 months. The virus was isolated from rectal swabs beginning 2 days postexposure (PE) and continued at irregular intervals. Virus shedding was detected on 24 separate occasions. The titer of the virus shed ran...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-5331-1_83

    authors: Woods RD,Wesley RD

    更新日期:1998-01-01 00:00:00

  • Radiation treatment of prostate bone metastases and the biological considerations.

    abstract::This contribution on the biology and management of bone metastases from prostatic cancer is divided into three parts. The first details a study conducted at Stanford University on the prevention of bone metastases in the lumbar spine, in patients in whom the lumbar spine has been irradiated coincidental to the radiati...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-3398-6_28

    authors: Bagshaw MA,Kaplan ID,Valdagni R,Cox RS

    更新日期:1992-01-01 00:00:00

  • Behavior of stimulated leukocytes in the pulmonary microcirculation of perfused rat lungs.

    abstract::To investigate the dynamics of activated leukocytes and the roles of CD18-ICAM-1 pathway, we examined the effects of rat IL-8 and monoclonal antibodies (mAbs) against CD18 and ICAM-1 on the behavior of leukocytes in microvessels of perfused rat lungs. Specific pathogen free male Sprague-Dawley rats were used. Perfused...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-5399-1_50

    authors: Aoki T,Suzuki Y,Nishio K,Suzuki K,Miyata A,Mori M,Takasugi T,Fujita H,Tsumura H,Ishimura Y,Suematsu M,Yamaguchi K

    更新日期:1997-01-01 00:00:00

  • Acute Myeloid Leukemia Stem Cell Heterogeneity and Its Clinical Relevance.

    abstract::The failure of complete remissions to reliably translate into cures in acute myeloid leukemia (AML) can be explained by the leukemia stem cell (LSC) paradigm, which hypothesizes that rare leukemia cells with stem cell features, including self-renewal capacity and drug resistance, are primarily responsible for both dis...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-14366-4_9

    authors: Karantanos T,Jones RJ

    更新日期:2019-01-01 00:00:00

  • Cis-regulation in the Drosophila Bithorax Complex.

    abstract::The discovery of the first homeotic mutation by Calvin Bridges in 1915 profoundly influenced the way we think about developmental processes. Although many mutations modify or deform morphological structures, homeotic mutations cause a spectacular phenotype in which a morphological structure develops like a copy of a s...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4419-6673-5_2

    authors: Maeda RK,Karch F

    更新日期:2010-01-01 00:00:00

  • The human exosome and disease.

    abstract::Long before the RNA degrading exosome was first described in the yeast Saccharomyces cerevisiae, the use of autoantibodies found in the sera of certain autoimmune patients allowed the identification of a complex of polypeptides which later appeared to be the human exosome. Today, the most extensively documented associ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:

    authors: Staals RH,Pruijn GJ

    更新日期:2010-01-01 00:00:00

  • Roles of transient receptor potential proteins (TRPs) in epidermal keratinocytes.

    abstract::Epidermal keratinocytes are the epithelial cells of mammalian skin. At the basal layer of the epidermis, these cells proliferate strongly, and as they move towards the skin surface, differentiation proceeds. At the uppermost layer of the epidermis, keratinocytes undergo apoptosis and die, forming a thin, water-imperme...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-94-007-0265-3_44

    authors: Denda M,Tsutsumi M

    更新日期:2011-01-01 00:00:00

  • Hemoglobin Dynamics in the Skeletal Muscle of Patients with Malignant Hematopoietic Disease.

    abstract::Impaired oxygen utilization in skeletal muscle potentially contributes to muscle weakness in patients with malignant hematopoietic disease and may explain altered hemodynamic responses to exercise in these patients. We investigated whether changes in hemoglobin parameters in the tibialis anterior muscle in patients wi...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-91287-5_46

    authors: Wakasugi T,Morishita S,Kaida K,Itani Y,Kodama N,Ikegame K,Ogawa H,Domen K

    更新日期:2018-01-01 00:00:00

  • Metabolic, morphologic and electrophysiologic profiles of human temporal lobe foci: an attempt at correlation.

    abstract::Our current understanding of focal seizures strongly suggests a model of damage and associated synaptic reorganization that leads to periodic 'spontaneous' hyperexcitation and/or sustained firing that generates seizures. Our working model of a human epileptic focus assumes that there will often be inexcitability near ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4684-7971-3_8

    authors: Babb TL

    更新日期:1986-01-01 00:00:00

  • Mouse Models of Brain Metastasis for Unravelling Tumour Progression.

    abstract::Secondary tumours in the brain account for 40 % of triple negative breast cancer patients, and the percentage may be higher at the time of autopsy. The use of in vivo models allow us to recapitulate the molecular mechanisms potentially used by circulating breast tumour cells to proliferate within the brain.Metastasis ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-26666-4_13

    authors: Soto MS,Sibson NR

    更新日期:2016-01-01 00:00:00

  • The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II.

    abstract::Apolipoproteins are a key component of lipid transport in the circulatory system and share a number of structural features that facilitate this role. When bound to lipoprotein particles, these proteins are relatively stable. However, in the absence of lipids they display conformational instability and a propensity to ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-17344-3_7

    authors: Ryan TM,Mok YF,Howlett GJ,Griffin MD

    更新日期:2015-01-01 00:00:00

  • Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate.

    abstract::Workers in the zinc processing, for example, welding or hot-dip galvanizing, are exposed to aerosols consisting of particles and gases, including zinc oxide (ZnO), which can affect human health. In this study, we addressed the effects of short-term controlled exposure to nano-sized ZnO on the airway inflammatory marke...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/5584_2020_572

    authors: Monsé C,Hagemeyer O,van Kampen V,Raulf M,Weiss T,Menne E,Jettkant B,Kendzia B,Merget R,Brüning T,Bünger J

    更新日期:2020-08-30 00:00:00

  • A possible role of iron deficiency in gastric cancer in Colombia.

    abstract::Through the efforts of Correa, Cuello, Haenszel, Tannenbaum and others it was learned that the incidence of gastric cancer in certain areas of Narino (Colombia) was among the highest in the world. These areas of high risk for gastric cancer were adjacent to an area of substantially lower risk. Gastric biopsies from he...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-1-4615-9200-6_9

    authors: Broitman SA,Velez H,Vitale JJ

    更新日期:1981-01-01 00:00:00

  • Evaluation of Different Blood Collection Tubes and Blood Storage Conditions for the Preservation and Stability of Cell-Free Circulating DNA for the Analysis of the Methylated mSEPT9 Colorectal Cancer Screening Marker.

    abstract::For the subsequent analysis of the methylated mSEPT9 colorectal cancer screening marker in plasma, different blood collection tubes and blood storage conditions were investigated. The study demonstrated that methylated Septin 9 (mSEPT9) can be consistently detected in plasma samples derived from whole blood samples co...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-3-319-42044-8_32

    authors: Distler J,Tetzner R,Weiss G,König T,Schlegel A,Bagrowski M

    更新日期:2016-01-01 00:00:00

  • Molecular Aspects of Heparanase Interaction with Heparan Sulfate, Heparin and Glycol Split Heparin.

    abstract::Heparanase is the principal enzyme that degrades heparan sulfate (HS) in both physiological (HS turnover) and pathological (tumor metastasis, inflammation) cell conditions, catalysing the hydrolysis of the β-1-4 glycosidic bond in -GlcUA-β(1-4)-GlcNX-. Despite efforts to define the minimum trisaccharide sequence that ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-030-34521-1_6

    authors: Elli S,Guerrini M

    更新日期:2020-01-01 00:00:00

  • Functional implication of taurine in aging.

    abstract::Age-related impairment of central functions is though to result from alterations of neurochemical indices of synaptic function. These neurochemical modifications involve structural proteins, neurotransmitters, neuropeptides and related receptors. Several studies demonstrated that GABA receptors, glutamic acid decarbox...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-0-387-75681-3_20

    authors: El Idrissi A,Boukarrou L,Splavnyk K,Zavyalova E,Meehan EF,L'Amoreaux W

    更新日期:2009-01-01 00:00:00

  • The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry.

    abstract::Store-operated Ca2+ entry fulfills a crucial role in controlling Ca2+ signals in almost all cells. The Ca2+-sensing stromal interaction molecule (STIM) proteins in the endoplasmic reticulum (ER) undergo complex conformational changes in response to depleted ER luminal Ca2+, allowing them to unfold and become trapped i...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1007/978-3-319-57732-6_5

    authors: Nwokonko RM,Cai X,Loktionova NA,Wang Y,Zhou Y,Gill DL

    更新日期:2017-01-01 00:00:00

  • Male SLE patients in Malta.

    abstract::The SLE patient database at the Rheumatology Clinic, St. Luke's Hospital includes 62 patients, 58 of which have complete data. The patients were grouped according to sex (7 males vs 51 females). The presentation, clinical manifestations, ACR criteria and laboratory findings of the 2 groups were analyzed and compared. ...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4615-4857-7_25

    authors: Camilleri F,Mallia C

    更新日期:1999-01-01 00:00:00

  • Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock.

    abstract::Shock, regardless of etiology, is characterized by decreased tissue perfusion resulting in cell death, organ dysfunction, and poor survival. Current therapies largely focus on restoring tissue perfusion through resuscitation but have failed to address the specific cellular dysfunction caused by shock. Acetylation is r...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4419-5638-5_11

    authors: Li Y,Alam HB

    更新日期:2012-01-01 00:00:00

  • Genetic polymorphism of chicken 7S immunoglobulins.

    abstract::A survey of 48 inbred lines derived from five sources in the United States and Europe revealed considerable genetic polymorphism of the CS-1 gene. A minimum of ten alleles were detected as unique combinations of CS-1 specificities. The relationship of some of the alleles would indicate that intracistronic recombinatio...

    journal_title:Advances in experimental medicine and biology

    pub_type: 杂志文章

    doi:10.1007/978-1-4613-4169-7_34

    authors: Wakeland EK,Foppoli JM,Benedict AA

    更新日期:1977-01-01 00:00:00