Abstract:
:Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8⁺ T cells may affect the primary response.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Remakus S,Sigal LJdoi
10.1007/978-1-4614-6217-0_9subject
Has Abstractpub_date
2013-01-01 00:00:00pages
77-86eissn
0065-2598issn
2214-8019journal_volume
785pub_type
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