Abstract：
:Adaptation to hypoxia is essential for regulating the survival and functions of hypoxic cells; it is mainly mediated by the hypoxia-inducible factor 1 (HIF1). The alpha subunit of HIF1 (HIF1α) is a well-known regulatory component of HIF1, which is tightly controlled by various types of HIF1α-regulating processes. Previous research has shown that microtubule-regulated HIF1α nuclear translocation is a key factor for HIF1 activation under hypoxia. In this review, we summarize experimental reports on the role of microtubule-associated factors, such as microtubule, dynein, and dynein adaptor protein, in nuclear translocation of HIF1α. Based upon scientific evidence, we propose a bicaudal D homolog (BICD) as a novel HIF1α translocation regulating factor. A deeper understanding of the mechanism of the action of regulatory factors in controlling HIF1α nuclear translocation will provide novel insights into cell biology under hypoxia.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Lee HJ,Han HJdoi
10.1007/978-3-030-34461-0_34subject
Has Abstractpub_date
2020-01-01 00:00:00pages
271-276eissn
0065-2598issn
2214-8019journal_volume
1232pub_type
杂志文章,评审abstract：:Lung diseases affect millions of individuals all over the world. Various environmental factors, such as toxins, chemical pollutants, detergents, viruses, bacteria, microbial dysbiosis, and allergens, contribute to the development of respiratory disorders. Exposure to these factors activates stress responses in host ce...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-030-45328-2_4
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-0-387-85998-9_19
更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/978-981-13-8023-5_50
更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4684-7790-0_3
更新日期：1983-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
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更新日期：1981-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：1994-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
