Abstract：
:In the visible/NIR (600-900 nm) three different redox centres are potentially detectable in vivo in mitochondrial cytochrome c oxidase: haem a (605nm), the binuclear haem a3/CuB centre (655 nm) and CuA (830 nm). In this paper we report changes in the steady state reduction of these centres following increases in the rate of electron entry into the purified enzyme complex under conditions of saturating oxygen tension. As turnover is increased all three centres becomes progressively reduced. Analysis of the steady states indicated that all three centres remained in apparent equilibrium with cytochrome c throughout the titration. The calculated redox potentials of CuA (+224 mV) and haem a (+267 mV) were consistent with previous equilibrium data. The 655 nm band was also found to be oxygen and flux sensitive. It may be a useful additional in vivo detectable chromophore. However, it titrated with an apparent redox potential of +230 mV, far from its equilibrium value (+400 mV). The implications of these results for the interpretation of non invasive measurements of mitochondrial function are discussed.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Cooper CE,Sharpe MA,Mason MG,Nicholls Pdoi
10.1007/978-0-387-85998-9_19subject
Has Abstractpub_date
2009-01-01 00:00:00pages
123-8eissn
0065-2598issn
2214-8019journal_volume
645pub_type
杂志文章abstract：:Administration of clenbuterol to rats in the drinking water over a four day period increased incorporation of [3H]leucine into muscle protein but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg.kg-1.day-...
journal_title：Advances in experimental medicine and biology
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更新日期：1986-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-94-024-0890-4_13
更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-90-481-3271-3_30
更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-981-13-3540-2_9
更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/978-3-319-60733-7_12
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
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journal_title：Advances in experimental medicine and biology
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更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2017-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2013-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-94-007-4584-1_25
更新日期：2012-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4419-1399-9_15
更新日期：2010-01-01 00:00:00
abstract：:Intravascular ultrasound (IVUS) is a new technique of tomographic visualization of the coronary arteries: its lumen, wall and pathology. Three dimensional (3D) reconstruction shows the tubular structure of the arterial wall and its pathology. IVUS has many advantages over coronary angiography: it has better resolution...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-4615-5959-7_17
更新日期：1997-01-01 00:00:00
abstract：:Two gross mechanisms of pathology are central to pulmonary arterial hypertension - increased pulmonary vascular tone and remodelling of the pulmonary arteries. These pathologies can be caused by a variety of aberrant processes, and combine to cause an increase in pulmonary vascular resistance and consequent right vent...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-1-60761-500-2_31
更新日期：2010-01-01 00:00:00
