Abstract:
:Due to the exponential growth of aging population worldwide, neurodegenerative diseases became a major public health concern. Among them, Alzheimer's disease (AD) prevails as the most common in the elderly, rendering it a research priority. After several decades considering the brain as an insulin-insensitive organ, recent advances proved a central role for this hormone in learning and memory processes and showed that AD shares a high number of features with systemic conditions characterized by insulin resistance. Mitochondrial dysfunction has also been widely demonstrated to play a major role in AD development supporting the idea that this neurodegenerative disease is characterized by a pronounced metabolic dysregulation. This chapter is intended to discuss evidence demonstrating the key role of insulin signaling and mitochondrial anomalies in AD.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Carvalho C,Cardoso SM,Correia SC,Moreira PIdoi
10.1007/978-981-13-3540-2_9subject
Has Abstractpub_date
2019-01-01 00:00:00pages
161-183eissn
0065-2598issn
2214-8019journal_volume
1128pub_type
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