Abstract:
:Abstract Of diverse growth factors that contribute to normal lung development, vascular endothelial growth factor (VEGF) plays an especially prominent role in the normal growth and development of the pulmonary circulation in the fetus and newborn. Strong experimental and clinical data support the role of impaired VEGF signaling in the pathogenesis of two major clinical disorders of the developing lung circulation: persistent pulmonary hypertension of the newborn (PPHN) and bronchopulmonary dysplasia (BPD). These disorders are each characterized by impaired vascular growth, structure and reactivity, which are at least partly due to endothelial cell dysfunction. This chapter will briefly discuss VEGF signaling during normal lung development and how disruption of VEGF signaling contribute to the pathogenesis of neonatal pulmonary vascular disease in these settings.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Abman SHdoi
10.1007/978-1-60761-500-2_21subject
Has Abstractpub_date
2010-01-01 00:00:00pages
323-35eissn
0065-2598issn
2214-8019journal_volume
661pub_type
杂志文章,评审abstract::Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 results in the spontaneous development of inflammatory bowel disease as a consequence of an excessive immune response to the gut microbiota. IL-10 a...
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pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::All who have contributed in writing this chapter have been patients and parents that have experienced an horrific life event. The horrific disease named necrotising fasciitis has affected our lives for ever. All four stories have explained how easily an everyday infection can develop incredibly quickly into a life-thr...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00