Taurine Chloramine Suppresses LPS-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglial Cells.

abstract：:Overhauser enhanced MRI (OMRI) is one of the free radical imaging technologies and has been used in biomedical research such as for partial oxygen measurements in tumor, and redox status in acute oxidative diseases. The external magnetic field of OMRI is frequently in the range of 5-10 mTesla to ensure microwave penet...

journal_title：Advances in experimental medicine and biology

authors： Tokunaga Y,Nakao M,Naganuma T,Ichikawa K

更新日期：2017-01-01 00:00:00

abstract：:Lipid A is a strong activator of monocytes to release immune stimulators such as proinflammatory cytokines. Overproduction of inflammatory cytokines such as TNF and IL-6 is known to cause septic shock that frequently leads to multiple organ failure and finally to death. In recent years, Lipid A has also been recognize...

journal_title：Advances in experimental medicine and biology

authors： Yamamoto M,Akira S

更新日期：2010-01-01 00:00:00

abstract：:The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endo...

journal_title：Advances in experimental medicine and biology

authors： Turner AJ,Brown CD,Carson JA,Barnes K

更新日期：2000-01-01 00:00:00

abstract：:We assessed neural sensitivity to interaural time differences (ITDs) conveyed in the temporal fine structure (TFS) of low-frequency sounds and ITDs conveyed in the temporal envelope of amplitude-modulated (AM'ed) high-frequency sounds. Using electroencephalography (EEG), we recorded brain activity to sounds in which t...

journal_title：Advances in experimental medicine and biology

authors： McAlpine D,Haywood N,Undurraga J,Marquardt T

更新日期：2016-01-01 00:00:00

abstract：:Taurine transport is important for volume regulation of cultured neurons and astroglial cells. Both cell types utilize similar mechanisms for taurine accumulation and efflux. However, taurine lost from cerebellar Purkinje cells in vivo is accumulated by adjacent astrocytes during hypoosmotic hyponatremia. To examine m...

journal_title：Advances in experimental medicine and biology

authors： Olson JE,Li GZ

更新日期：2000-01-01 00:00:00

abstract：:We investigated, with use of a technique of feedback analysis, the dynamic changes in and around the renin-angiotensin system in vivo induced by ACE inhibition. Prolonged studies were performed over a half year on rabbits, which were treated by daily injections of saline or one of the inhibitors as follows: captopril,...

journal_title：Advances in experimental medicine and biology

authors： Wada T,Aoyagi T

更新日期：1989-01-01 00:00:00

abstract：:Asian (Elephas maximus) and African (Loxodonta africana) elephants serve as important keystone, umbrella and flagship species. Despite that, population numbers are declining, due mainly to poaching and habitat destruction. Understanding reproductive mechanisms is vital to effective management, particularly insurance p...

journal_title：Advances in experimental medicine and biology

authors： Brown JL

更新日期：2019-01-01 00:00:00

abstract：:Although mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and disrupted lipid and calcium (Ca2+) homeostasis are classically associated with both insulin resistance and β-cell dysfunction in type 2 diabetes mellitus (T2DM), the interplay between these metabolic stresses is less known. Both organelles inte...

journal_title：Advances in experimental medicine and biology

authors： Rieusset J

更新日期：2017-01-01 00:00:00

abstract：:Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of...

journal_title：Advances in experimental medicine and biology

authors： Horn D

更新日期：2008-01-01 00:00:00

abstract：:In this chapter, we first briefly review the history of Zika virus (ZIKV) over the past 70 years since its discovery. We then focus on the ZIKV NS2B/NS3 protease, a major potential target for anti-ZIKV therapeutics. We describe the structure of the complex between Zika virus NS2B-NS3 protease and a peptide boronic-aci...

journal_title：Advances in experimental medicine and biology

authors： Hilgenfeld R,Lei J,Zhang L

更新日期：2018-01-01 00:00:00

abstract：:Substrate/inhibitor specificities of nucleoside analogues with modified sugar moieties toward highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined. Substrate activities of cytosine nucleosides vs dCK were as follows: 2'-fluoro-dC > 2'-O-methyl-C >...

journal_title：Advances in experimental medicine and biology

authors： Kierdaszuk B,Krawiec K,Kazimierczuk Z,Jacobsson U,Johansson NG,Munch-Petersen B,Eriksson S,Shugar D

更新日期：1998-01-01 00:00:00

abstract：:Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functiona...

journal_title：Advances in experimental medicine and biology

authors： Handford PA,Korona B,Suckling R,Redfield C,Lea SM

更新日期：2018-01-01 00:00:00

abstract：:In this chapter, the impact of HCN1 channels on the retinal functional properties was presented. HCN1 channel loss led to an intensity-dependent prolongation of the rod system response, in agreement with the threshold mechanism of activation of the channel. Rod outer segment functionality was not altered, supporting t...

journal_title：Advances in experimental medicine and biology

authors： Tanimoto N,Brombas A,Müller F,Seeliger MW

更新日期：2012-01-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a severe systemic syndrome associated with hyperactivation of macrophages and impaired regulation of the immune system. Two forms of HLH are currently recognized: genetically determined or familial (FHLH), and secondarily developed in the course of primary diseases, like aut...

journal_title：Advances in experimental medicine and biology

authors： Popko K,Jasińska J,Górska E,Demkow U,Balwierz W,Maciejka-Kembłowska L,Badowska W,Wachowiak J,Drabko K,Malinowska I

更新日期：2016-01-01 00:00:00

abstract：:The origin of DNA replication of bacteriophage f1 consists of two functional domains: 1) a "core region", about 40 nucleotides long, that is absolutely required for viral (plus) strand replication and contains three distinct but partially overlapping signals, a) the recognition sequence for the viral gene II protein, ...

journal_title：Advances in experimental medicine and biology

authors： Dotto GP,Horiuchi K,Zinder ND

更新日期：1984-01-01 00:00:00

abstract：:Hypoxia is a hallmark of tumors leading to (mal-)adaptive processes, development of aggressive phenotypes and treatment resistance. Based on underlying mechanisms and their duration, two main types of hypoxia have been identified, coexisting with complex spatial and temporal heterogeneities. Chronic hypoxia is mainly ...

journal_title：Advances in experimental medicine and biology

authors： Vaupel P,Mayer A

更新日期：2014-01-01 00:00:00

abstract：:In hypoxic rabbits, different levels of Pco2 before and after carotid chemodenervation were applied in order to get information about the acid-base status and the position of the O2-Hb dissociation curve (ODC). A CO2-induced change in pH caused a smaller change in the half-saturation pressure (P50) than was to be expe...

journal_title：Advances in experimental medicine and biology

authors： Kiwull-Schöne H,Gärtner B,Kiwull P

更新日期：1984-01-01 00:00:00

abstract：:Skeletal muscle alpha-actin is the principal protein component of the adult skeletal muscle thin filament. The interaction between skeletal muscle alpha-actin and the various myosin heavy chain proteins in the different muscle fibre types generates the force of muscle contraction. Skeletal muscle alpha-alpha actin is ...

journal_title：Advances in experimental medicine and biology

authors： North KN,Laing NG

更新日期：2008-01-01 00:00:00

abstract：:The aim of any pancreatic islet isolation is obtaining pure, viable and functional pancreatic islets, either for in vitro or in vivo purposes. The islets of Langerhans are complex microorgans with the important role of regulating glucose homeostasis. Imbalances in glucose homeostasis lead to diabetes, which is defined...

journal_title：Advances in experimental medicine and biology

authors： Ramírez-Domínguez M

更新日期：2016-01-01 00:00:00

abstract：:We have examined the question of how hormones regulate the biosynthesis of gonadotropins. In particular we have studied the effects of gonadal sex steroid hormones on the regulation of LH subunit gene expression to determine whether they may occur at the pre-translational level. Success in the molecular cloning of cDN...

journal_title：Advances in experimental medicine and biology

authors： Chin WW,Gharib SD

更新日期：1986-01-01 00:00:00

abstract：:Chronic nonspecific low back pain is a frequent clinical condition affecting the general population and influencing disability level and quality of life. We performed a single-blinded, randomized, and controlled study to compare the effectiveness of manual pressure release (MPR) and electrical neuromodulation (ENM) tr...

journal_title：Advances in experimental medicine and biology

authors： Barassi G,Pokorski M,Di Matteo C,Supplizi M,Prosperi L,Guglielmi V,Younes A,Della Rovere F,Di Iorio A

更新日期：2021-01-21 00:00:00

abstract：:Heterogeneously distributed hypoxic areas are a characteristic property of locally advanced breast cancers. Hypoxia results from an imbalance between the supply and consumption of oxygen (O2). Major pathogenetic mechanisms for the emergence of hypoxia are (i) structural and functional abnormalities in the tumor microv...

journal_title：Advances in experimental medicine and biology

authors： Vaupel P,Mayer A,Briest S,Höckel M

更新日期：2005-01-01 00:00:00

abstract：:This chapter overviews roles of DNA methylation in inflammatory cell biology with the focuses on lymphocytes and macrophages/monocytes in lung diseases, although the molecular mechanisms by which target genes are methylated and regulated in lung diseases remain unclear. Most of epigenetic studies on DNA methylation of...

journal_title：Advances in experimental medicine and biology

authors： Liu Y,Gao H,Wang X,Zeng Y

更新日期：2020-01-01 00:00:00

abstract：:Embryonic stem (ES) cells undergo self-renewal and are pluripotent, i.e., they can give rise to all the types of specialised cells in the body. Scientific knowledge on ES cells is increasing rapidly, leading to opportunities for establishment of ES cell-based in vitro tests for drug discovery, preclinical safety pharm...

journal_title：Advances in experimental medicine and biology

authors： Stummann TC,Bremer S

更新日期：2012-01-01 00:00:00

abstract：:It is well established that palmitoylation plays a key role in the regulation of immune checkpoints, but the technical challenges in detecting protein palmitoylation have significantly prohibited further researches in this field. Till now, different approaches have been proposed, such as mutagenesis, antibody-based me...

journal_title：Advances in experimental medicine and biology

authors： Lu H,Fang C

更新日期：2020-01-01 00:00:00

abstract：:Both hepatic lipogenesis from glucose and gluconeogenesis from lactate are inhibited by substrates for mixed function oxidation such as aminopyrine. These effects are inducible with phenobarbital pretreatment and absent with a demethylated product of aminopyrine metabolism, aminophenylpyrazolone. The data indicate tha...

journal_title：Advances in experimental medicine and biology

authors： Thurman RG,Marazzo DP

更新日期：1975-01-01 00:00:00

abstract：:Humans with mutations in the phototransduction pathway develop forms of retinal degeneration, such as retinitis pigmentosa, cone dystrophy, or Leber congenital amaurosis. Similarly, numerous phototransduction mutant animal models resemble retinal degeneration. In our lab, using a zebrafish model, we study cone-specifi...

journal_title：Advances in experimental medicine and biology

authors： Iribarne M,Masai I

更新日期：2018-01-01 00:00:00

abstract：:The idea that exposure to adverse environmental conditions and lifestyle choices during pregnancy can result in fetal programming that underlies disease susceptibility in adulthood is now widely accepted. Fetal alcohol exposed offspring displays many behavioral and physiological abnormalities including neuroendocrine-...

journal_title：Advances in experimental medicine and biology

authors： Sarkar DK

更新日期：2015-01-01 00:00:00

abstract：:Two-component systems (TCSs) are well conserved among E. coli strains, including pathogenic E. coli and also closely related Shigella spp. Although 25% of the genome of pathogenic E. coli is strain-specific, only small number of strain-specific TCSs is found. Regulation of virulence genes in response to environmental ...

journal_title：Advances in experimental medicine and biology

authors： Tobe T

更新日期：2008-01-01 00:00:00

abstract：:Cyanobacteria become increasingly dominant as concentrations of TP and TN increase during eutrophication of lakes, rivers and estuaries. Temporal dynamics of cyanobacteria blooms are variable--in some systems persistent blooms occur in summer to fall, whereas in other systems blooms are more sporadic. Cyanobacteria bl...

journal_title：Advances in experimental medicine and biology

authors： Havens KE

更新日期：2008-01-01 00:00:00