Abstract：
:An overall view of the contractile process that has emerged from -temperature-studies on active muscle is outlined. In isometric muscle, a small rapid temperature-jump (T-jump) enhances an early, pre-phosphate release, step in the acto-myosin (crossbridge) ATPase cycle and induces a characteristic rise in force indicating that crossbridge force generation is endothermic (force rises when heat is absorbed). Sigmoidal temperature dependence of steady force is largely due to the endothermic nature of force generation. During shortening, when muscle force is decreased, the T-jump force generation is enhanced; conversely, when a muscle is lengthening and its force increased, the T-jump force generation is inhibited. Taking T-jump force generation as a signature of the crossbridge - ATPase cycle, the results suggest that during lengthening the ATPase cycle is truncated before endothermic force generation, whereas during shortening this step and the ATPase cycle, are accelerated; this readily provides a molecular basis for the Fenn effect.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Ranatunga KW,Coupland MEdoi
10.1007/978-1-4419-6366-6_14subject
Has Abstractpub_date
2010-01-01 00:00:00pages
247-66eissn
0065-2598issn
2214-8019journal_volume
682pub_type
杂志文章,评审abstract：:Nitric oxide (NO) regulates normal vasomotor tone and modulates important homeostatic functions such as thrombosis, cellular proliferation, and adhesion molecule expression. Recent data implicate a critical function for hemoglobin and the erythrocyte in regulating the bioavailability of NO in the vascular compartment....
journal_title：Advances in experimental medicine and biology
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更新日期：2015-01-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：1977-01-01 00:00:00
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doi：10.1007/978-981-32-9421-9_8
更新日期：2019-01-01 00:00:00
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doi：10.1007/978-1-4939-2981-8_113
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更新日期：2014-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
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更新日期：2015-01-01 00:00:00
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abstract：:Mitochondria Na(+)-Ca(2+) exchange (NCX(mit)) was first discovered by Carafoli et al. in 1974. Thereafter, the mechanisms and roles of NCX(mit) have been extensively studied. We review NCX(mit) in cardiomyocytes and lymphocytes by presenting our recent studies on it. Studies of NCX(mit) in rat ventricular cells demons...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2009-01-01 00:00:00
abstract：:Antibodies against thyroid microsomal antigen (thyroid peroxidase, TMA/TPO) and myeloperoxidase (MPO) were measured from 115 patients with vasculitic disorders and 144 patients with suspected thyroid disorders. Nineteen patients, three with vasculitis and 16 with thyroid disorders, were shown to have both TPO and MPO ...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
doi：10.1007/978-1-4757-9182-2_12
更新日期：1993-01-01 00:00:00
