Single-molecule studies of viral DNA packaging.

Abstract:

:Many double-stranded DNA bacteriophages and viruses use specialized ATP-driven molecular machines to package their genomes into tightly confined procapsid shells. Over the last decade, single-molecule approaches - and in particular, optical tweezers - have made key contributions to our understanding of this remarkable process. In this chapter, we review these advances and the insights they have provided on the packaging mechanisms of three bacteriophages: φ 29, λ, and T4.

journal_name

Adv Exp Med Biol

authors

Chemla YR,Smith DE

doi

10.1007/978-1-4614-0980-9_24

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

549-84

eissn

0065-2598

issn

2214-8019

journal_volume

726

pub_type

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