Abstract:
:In order to better understand the mechanisms of cerebrovascular development and differentiation, the leptomeningeal microcirculation was analyzed using in vivo fluorescence video-microscopy in neonatal (1, 9, and 12 day old) Sprague-Dawley rats. The pattern of flow distribution was reconstructed, the location of radially emerging intracortical veins was identified and the minimum distance between these vessels was measured. We found no AV connections in the leptomeningeal vasculature of the neonatal rat in all examined animals. The LVP in the neonatal period of life is a venous system and probably does not serve as a major source of oxygen supply to cerebral tissue. After birth, the number of radial vessels does not increase, suggesting that intracortical vascularization continues by the branching of existing radial vessels.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Krolo I,Hudetz AGdoi
10.1007/978-1-4615-4863-8_41subject
Has Abstractpub_date
1998-01-01 00:00:00pages
349-54eissn
0065-2598issn
2214-8019journal_volume
454pub_type
杂志文章abstract::Neonates supported on extracorporeal membrane oxygenation (ECMO) are at high risk of brain injury due to haemodynamic instability. In order to monitor cerebral and peripheral (muscle) haemodynamic and oxygenation changes in this population we used a dual-channel near-infrared spectroscopy (NIRS) system. In addition, t...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::Since many aspects of schizophrenia are also manifested at the peripheral level in proliferating cell types, this chapter describes the analysis of skin fibroblasts biopsied from living patients. The method focuses on cell culture and sample preparation for characterization of the model. The resulting cell extracts ca...
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doi:10.1007/978-1-4419-7210-1_1
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abstract::Stimulator of interferon (IFN) genes (STING) is a key mediator in the immune response to cytoplasmic DNA sensed by cyclic GMP-AMP (cGAMP) synthase (cGAS). After synthesis by cGAS, cGAMP acts as a second messenger activating STING in the cell harboring cytoplasmic DNA but also in adjacent cells through gap junction tra...
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journal_title:Advances in experimental medicine and biology
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-0075-9_52
更新日期:2003-01-01 00:00:00
abstract::Monoclonal antibodies are universal binding molecules with a high specificity for their target and are indispensable tools in research, diagnostics and therapy. The biotechnological generation of monoclonal antibodies was enabled by the hybridoma technology published in 1975 by Köhler and Milstein. Today monoclonal an...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-32805-8_2
更新日期:2016-01-01 00:00:00
abstract::In this model of pancreatic regeneration, the initial trophic effect of cellophane wrapping is upon the ductular-epithelium, as shown by autoradiographic analysis following a single pulse of 3H-TdR. The uptake of 3H-TdR by ductular cells is maximal approximately 4 weeks before the peak uptake of the label by islet cel...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-3448-8_14
更新日期:1992-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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doi:10.1007/978-94-007-4549-0_19
更新日期:2013-01-01 00:00:00
abstract::The IGF binding proteins (IGFBPs) comprise at least six distinct species which may modulate the action of IGFs. IGFs are important regulators of fetal growth and differentiation. We have studied the mRNA expression of the six IGFBPs during post-implantation embryogenesis (day 11-18) by in situ hybridization techniques...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-2988-0_26
更新日期:1993-01-01 00:00:00
abstract::In order to investigate the spinal cord surface PO2 (sPO2) reaction to hypovolemic hypotension, nine female pigs (25 kg bw) were premedicated, anesthetized, intubated and artificially ventilated with N2O:O2 = 3:1. Following laminectomy from L3 to L5, sPO2 was measured on the dorsal side of the exposed spinal cord usin...
journal_title:Advances in experimental medicine and biology
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更新日期:1986-01-01 00:00:00
abstract::The purpose of this study was to develop a non-dimensional approach towards the description of interaction between the three respiratory stimuli of hypoxia, hypercapnia and exercise and to use this approach to quantify the relative strengths of their interactions. Only a part of the study related to the overall intera...
journal_title:Advances in experimental medicine and biology
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abstract::A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine is profitable for diabetes mellitus a...
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::Raw soya flour (RSF) feeding to rats produces pancreatic hypertrophy and hyperplasia, and, if sufficiently prolonged, the spontaneous development of pancreatic neoplasms and the potentiation of pancreatic carcinogens. With continuous exposure to RSF the threshold dose for pancreatic growth is approximately 20% RSF, bu...
journal_title:Advances in experimental medicine and biology
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更新日期:1986-01-01 00:00:00
abstract::Serine/threonine kinase Akt is a downstream effector of insulin receptor/PI3K pathway that is involved in many processes, including providing neuroprotection to stressed rod photoreceptor cells. Akt signaling is known to be regulated by the serine/threonine phosphatases, PHLPP (PH domain and leucine rich repeat protei...
journal_title:Advances in experimental medicine and biology
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更新日期:2016-01-01 00:00:00
abstract::Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment.This work was...
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更新日期:2020-01-01 00:00:00
abstract::Viruses and their protein capsids can be regarded as biologically evolved nanomachines able to perform multiple, complex biological functions through coordinated mechano-chemical actions during the infectious cycle. The advent of nanoscience and nanotechnology has opened up, in the last 10 years or so, a vast number o...
journal_title:Advances in experimental medicine and biology
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abstract::Pretreatment of rats with large doses of vitamin A (retinol) dramatically increased the hepatotoxicity of carbon tetrachloride (CCl4). Experiments were performed to elucidate the mechanism of this potentiation. Hypervitaminosis A was produced by oral administration of retinol, 250,000 IU/kg for seven days. CCl4 was th...
journal_title:Advances in experimental medicine and biology
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更新日期:1991-01-01 00:00:00
abstract::The XPC protein is a component of a heterotrimeric complex that is essential for damage recognition in a nucleotide excision repair subpathway that operates throughout the genome. Biochemical analyses have revealed that the broad substrate specificity of this repair system is based on the structure-specific DNA bindin...
journal_title:Advances in experimental medicine and biology
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更新日期:2008-01-01 00:00:00
abstract::High density lipoproteins (HDL) not only provide a serum transport vector for paraoxonase-1 (PON1) but also contribute to enzyme activity, stability and, consequently, function. The contribution of the apolipoprotein (apo) components of HDL to overall PON1 activity and function is not clearly established. ApoAI appear...
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更新日期:2010-01-01 00:00:00
abstract::Fungi that tolerate very high environmental NaCl concentrations are good model systems to study mechanisms that enable them to endure osmotic and salinity stress. The whole genome sequences of six such fungal species have been analysed: Hortaea werneckii, Wallemia ichthyophaga and four Aureobasidium spp.: A. pullulans...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-25304-6_13
更新日期:2016-01-01 00:00:00
abstract::Angiogenesis, the process by which new blood vessels are formed from preexisting vessels, is essential for growth and progression of solid tumors. A number of growth factors regulate angiogenesis, but vascular endothelial growth factor (VEGF) is the most important. Activation of the VEGF pathway triggers a range of si...
journal_title:Advances in experimental medicine and biology
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更新日期:2006-01-01 00:00:00