cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity.

Abstract:

:Stimulator of interferon (IFN) genes (STING) is a key mediator in the immune response to cytoplasmic DNA sensed by cyclic GMP-AMP (cGAMP) synthase (cGAS). After synthesis by cGAS, cGAMP acts as a second messenger activating STING in the cell harboring cytoplasmic DNA but also in adjacent cells through gap junction transfer. While the role of the cGAS-STING pathway in pathogen detection is now well established, its importance in cancer immunity has only recently started to emerge. Nonetheless, STING appears to be an essential component in the recruitment of immune cells to the tumor microenvironment, which is paramount to immune clearance of the tumor. This review presents an overview of the growing literature around the role of the cGAS-STING pathway in the tumor microenvironment, with a specific focus on the role that cancer cells may play in the direct activation of this pathway, and its amplification through cell-cell transfer of cGAMP.

journal_name

Adv Exp Med Biol

authors

Pépin G,Gantier MP

doi

10.1007/978-981-10-5987-2_8

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

175-194

eissn

0065-2598

issn

2214-8019

journal_volume

1024

pub_type

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