Abstract:
:During the development of an amplification refractory mutation system (ARMS) assay for the detection of the Delta F508 mutation and corresponding normal locus in cystic fibrosis we discovered a family in which a further variant of the sequence exists. PCR amplification and direct sequencing of a region of exon 10 of the CFTR locus indicated the deletion of the three base pairs encoding isoleucine or isoleucine, or possibly the presence of a single base substitution in conjunction with the Delta F508 mutation. The resulting protein has a deletion of an isoleucine residue at position 507 as opposed to the previously described deletion of phenylalanine at position 508. We conclude that the loss of an isoleucine residue at position 507 (Delta I507) is another defective variant of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene product.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Schwarz M,Summers C,Heptinstall L,Newton C,Markham A,Super Mdoi
10.1007/978-1-4684-5934-0_48subject
Has Abstractpub_date
1991-01-01 00:00:00pages
393-8eissn
0065-2598issn
2214-8019journal_volume
290pub_type
杂志文章abstract::Allospecific suppressor T cells can be generated by allostimulating thymus, spleen and lymph node cells in culture. Bone marrow cells do not yield suppressor lymphocytes. While the efficiency of thymocytes for suppressor cell generation decreases with the age of thymus donors, the efficiency of spleen increases with a...
journal_title:Advances in experimental medicine and biology
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doi:10.1007/978-1-4615-9101-6_48
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abstract::We have demonstrated that kinins are generated following nasal challenge with allergen of allergic (5.6 +/- 0.17 ng/m-), but not nonallergic (0.04 +/- .02 ng/ml), individuals (n = 8 in each case). The presence of kinin was highly correlated with that of histamine and TAME-esterase activity and with clinical symptoms (...
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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abstract::The apical plasma membrane domain of retinal pigment epithelial (RPE) cells in the eye faces the outer segment portions of rods and cones and the interphotoreceptor matrix in the subretinal space. Two important receptor-mediated interactions between the apical surface of the retinal pigment epithelium (RPE) and adjace...
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::The role of CD4+ T cells in altering the activity of cytotoxic T lymphocytes (CTL) during infection of the central nervous system (CNS) by the neuroptropic JHMV strain of mouse hepatitis virus was examined. Adoptive transfer of in vitro activated CTL into CD4-depleted and control recipients showed that CTL were not ef...
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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更新日期:2020-01-01 00:00:00
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abstract::Recent progress in tissue-resident adult stem/progenitor cell research has inspired great interest because these immature cells from your own body can act as potential, easily accessible cell sources for cell transplantation in regenerative medicine and cancer therapies. The use of adult stem/progenitor cells endowed ...
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pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract::What is the function of the Hox genes? At first glance, it is a curious question. Indeed, the answer seems so obvious that several authors have spoken of 'the Hox function' about some of the Hox genes, namely Hox3/zen and Hox6/ftz that seem to have lost it during the evolution of Arthropods. What these authors meant i...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00