Abstract：
:In order to investigate the spinal cord surface PO2 (sPO2) reaction to hypovolemic hypotension, nine female pigs (25 kg bw) were premedicated, anesthetized, intubated and artificially ventilated with N2O:O2 = 3:1. Following laminectomy from L3 to L5, sPO2 was measured on the dorsal side of the exposed spinal cord using six gold cathodes (luminal diameter 15 microns) while MAP (mean +/- SD) was lowered in steps of about 10 Torr by bleeding into a reservoir from 69.3 +/- 10.1 Torr to extreme low values of 13.3 +/- 3.1 Torr. Only a slight decrease of lumbar sPO2 (mean +/- SD) from 33.5 +/- 7.2 Torr to 27.6 +/- 4.8 Torr was evaluated from the data in response to MAP reduction to 50.2 +/- 3.5 Torr. Below that value, a marked proportional decrease of sPO2 and MAP was observed (0.65 Torr/Torr) corresponding to pressure passive flow behavior of the Hagen Poisseuille Law ("loss of autoregulation"). Four to five minutes after start of reinfusion both sPO2 and MAP showed an overshoot with maximum values of 54.0 +/- 11.1 Torr resp. 102.6 +/- 18 Torr. Initial values were approximated about 15 min. later. Histograms plotted from the individual sPO2 values of all pigs and of all the different experimental stages showed signs of severe hypoxia only if MAP was reduced below about 30 Torr. In general, this situation was reversible within reinfusion, only one of the nine pigs did not tolerate hemorrhagic hypoxia induced by MAP reduction to less than 30 Torr for at least 5-10 min. Nevertheless, the experiments showed a considerable circulatory stability in the investigated pigs.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Metzger H,Hartmann M,Wadouh Fdoi
10.1007/978-1-4684-5188-7_29subject
Has Abstractpub_date
1986-01-01 00:00:00pages
223-32eissn
0065-2598issn
2214-8019journal_volume
200pub_type
杂志文章abstract：:Inbred mice are routinely used as genetic models in lung biology. Among many phenotypic differences in lung function and structure, C3H/HeJ (C3) and C57BL/6J (B6) inbred mice also demonstrate a significantly different ventilatory pattern during acute hypoxic challenge. The present study rejects the hypothesis that a g...
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