Abstract:
:Anthranilic acid (AA) has been attracted considerable attention as one of the L-tryptophan-kynurenine pathway metabolites in the central nervous system. In this study, the concentration of L-kynurenine (L-KYN) and AA in serum and CSF, and its related enzyme activities were determined in several species. In rabbits, CSF AA concentrations were lower and serum AA concentrations were slightly higher than those in other species. However, the concentrations of L-KYN were substantially higher in rabbits in both serum and CSF compared with other species. Tissue enzyme activities varied among species. In rabbits, lung IDO activities were higher, but liver kynurenine 3-hydroxylase activities were lower than those of the other species tested. Furthermore, brain kynurenine 3-hydroxylase activities were higher in gerbils than those in other species. These results clearly demonstrated that kynurenine pathway enzyme activities and metabolite concentrations vary with species.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Fujigaki S,Saito K,Fujii H,Wada H,Seishima Mdoi
10.1007/978-1-4615-4709-9_79subject
Has Abstractpub_date
1999-01-01 00:00:00pages
625-8eissn
0065-2598issn
2214-8019journal_volume
467pub_type
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