当前位置： SCI文献检索 > Advances in Experimental Medicine and Biology期刊下所有文献 > Signaling through the extracellular calcium-sensing receptor (CaSR).

Signaling through the extracellular calcium-sensing receptor (CaSR).

Abstract：

:The extracellular calcium ([Formula: see text])-sensing receptor (CaSR) was the first GPCR identified whose principal physiological ligand is an ion, namely extracellular Ca(2+). It maintains the near constancy of [Formula: see text] that complex organisms require to ensure normal cellular function. A wealth of information has accumulated over the past two decades about the CaSR's structure and function, its role in diseases and CaSR-based therapeutics. This review briefly describes the CaSR and key features of its structure and function, then discusses the extracellular signals modulating its activity, provides an overview of the intracellular signaling pathways that it controls, and, finally, briefly describes CaSR signaling both in tissues participating in [Formula: see text] homeostasis as well as those that do not. Factors controlling CaSR signaling include various factors affecting the expression of the CaSR gene as well as modulation of its trafficking to and from the cell surface. The dimeric cell surface CaSR, in turn, links to various heterotrimeric and small molecular weight G proteins to regulate intracellular second messengers, lipid kinases, various protein kinases, and transcription factors that are part of the machinery enabling the receptor to modulate the functions of the wide variety of cells in which it is expressed. CaSR signaling is impacted by its interactions with several binding partners in addition to signaling elements per se (i.e., G proteins), including filamin-A and caveolin-1. These latter two proteins act as scaffolds that bind signaling components and other key cellular elements (e.g., the cytoskeleton). Thus CaSR signaling likely does not take place randomly throughout the cell, but is compartmentalized and organized so as to facilitate the interaction of the receptor with its various signaling pathways.

journal_name

Adv Exp Med Biol

journal_title

Advances in experimental medicine and biology

authors

Chakravarti B,Chattopadhyay N,Brown EM

doi

10.1007/978-94-007-2888-2_5

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

103-42

eissn

0065-2598

issn

2214-8019

journal_volume

740

pub_type

杂志文章,评审

在线工具

Signaling through the extracellular calcium-sensing receptor (CaSR).