Abstract:
:Stroke-prone spontaneously hypertensive rats (SHRSP) are liable to suffer a stroke between 25 and 40 weeks of age. Left ventricular capillarity was studied in 40-week-old SHRSP to clarify the effects of hypertrophic changes in cardiomyocytes on oxygen transport capacity within the tissue. The innermost region of the left ventricular subendocardium at the level of the maximum diameter of the heart was investigated. Methods for sectioning and differential staining of arteriolar, intermediate and venular capillaries, and measurements for determining capillarity parameters were as previously described. Total capillary density decreased, while capillary domain areas increased along the whole capillary pathway. These changes in SHRSP seemed unfavorable for oxygen supply to ventricular tissues. To minimize the effects of the adverse changes, the ratio of the capillary to myocyte number increased markedly. The proportion of arteriolar capillaries increased and the venular proportion decreased.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Koyama T,Gao M,Batra S,Togashi H,Saito Hdoi
10.1007/978-1-4615-5865-1_46subject
Has Abstractpub_date
1997-01-01 00:00:00pages
365-8eissn
0065-2598issn
2214-8019journal_volume
411pub_type
杂志文章abstract::Hematopoiesis is a complex and strongly regulated process. In case of regenerative pressure, efficient recovery of blood cell counts is crucial for survival of an individual. We propose a quantitative mathematical model of white blood cell formation based on the following cell parameters: (1) proliferation rate, (2) s...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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abstract::Patients with chronic obstructive pulmonary disease (COPD) have the lower airways colonized with pathogenic bacteria in a stable period of the disease and during exacerbations. The etiology of bacterial exacerbations of COPD depends on the underlying disease, the frequency of exacerbations and antibiotic therapy. Micr...
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abstract::So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japonicum, G. capense, G. australe, G. tsugae, G. applanatum, G. tropicus, G. boniense, G. duropora, G. resinaceum, G. theaecolum, G. cochlear, G. atrum, G. formosanum, G. boninense, G. colossum, G. concin...
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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abstract::Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated by c-Myc and c-Jun oncogenes. To explore whether blocking of TauT inhibits tumor ...
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