Abstract:
:Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell functions and edits tumor immunology. Recent findings in immune cell metabolism hold the promising possibilities toward clinical therapeutics for treating cancer. This chapter introduces the updated understandings of metabolic reprogramming of immune cells in the TME and suggests new directions in manipulation of immune responses for cancer diagnosis and therapy.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Li Y,Wan YY,Zhu Bdoi
10.1007/978-94-024-1170-6_5subject
Has Abstractpub_date
2017-01-01 00:00:00pages
163-196eissn
0065-2598issn
2214-8019journal_volume
1011pub_type
杂志文章,评审abstract::One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF), which demonstrates a duality between these two processes. Thrombus is structured by numerous elements, including endothelial cells, platelets, plasma proteins and shear stress alteration. In circulation, once a vessel wall is inju...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/5584_2016_122
更新日期:2017-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-5766-7_41
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abstract::The Primo Vascular System (PVS) is new to most scientists despite that it was discovered in the 1960s by Bonghan Kim. Out of the many physiological functions reported, one of the most important PVS functions appears to be its role in the regeneration via a small (~1 μm) subcellular body called 'sanal.' According to Ki...
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-5143-6_55
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-319-26666-4_3
更新日期:2016-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 临床试验,杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-3-319-47656-8_7
更新日期:2017-01-01 00:00:00
abstract::Ovarian cancer is the fifth most common cancer in women and the leading cause of death from gynaecological malignancy in the Western world. The majority of ovarian cancers are diagnosed at an advanced stage and this is due to lack of a reliable screening test and the vagueness of symptoms. Early diagnosis is key as th...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-23730-5_8
更新日期:2015-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-33943-6_27
更新日期:2016-01-01 00:00:00
abstract::Plasma renin activity, blood angiotensin I, urinary kallikrein and blood bradykinin levels have been measured concurrently in rats over a range of daily sodium intake. Plasma renin activity, blood angiotensin I levels and urinary kallikrein were significantly increased by the low sodium diet (0.02 mmole per day). Brad...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::In summary, it can be said that in spite of possible limitations, this technique provides previously unattainable data on capillary flow pattern in the myocardium. Qualitative and quantitative results indicate that the following anatomical and physiological concepts should be incorporated in any further modelling of o...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4615-9510-6_53
更新日期:1988-01-01 00:00:00
abstract::The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated as a dynamic bioactive agent. Over two decades of research has begun to characterize various regulatory roles for C1P from mammalian inflammatory response and wound healing to cellular proliferation and survival. As a metabolite of the intr...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-030-21162-2_5
更新日期:2019-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
abstract::Screening of recombinant cosmid and phage libraries with a rabbit C alpha cDNA probe has identified a total of seven C alpha genes organized into two clusters; one cluster contains four genes and the other cluster, three genes. Southern blot analysis of genomic DNA indicates that the rabbit genome contains a minimum o...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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abstract::The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The...
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abstract::Cytochrome P450 enzymes (P450s or CYPs) catalyze an enormous variety of oxidative reactions in organisms from all major domains of life. Their monooxygenase activity relies on the reductive scission of molecular oxygen (O2) bound to P450 heme iron, and thus on the delivery of two electrons to the heme iron at discrete...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
doi:10.1007/978-3-319-16009-2_11
更新日期:2015-01-01 00:00:00
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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journal_title:Advances in experimental medicine and biology
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更新日期:2020-01-01 00:00:00
abstract::Kallikreins were localized in the human parotid gland and in the human kidney from two different aspects of the enzyme: the enzyme antigenicity and the enzyme activity. In the human parotid gland, the kallikrein antigenicity and the enzyme activity were identical in their locations in the ductal cells. In the human ki...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4684-5143-6_4
更新日期:1986-01-01 00:00:00
abstract::De novo synthesis of RNA sequences corresponding to intervening as well as to structural sequences of the ovalbumin gene have been detected in isolated oviduct nuclei. Their presence in the nuclear transcripts and their time course of induction support the hypothesis that transcription of structural and intervening se...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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