Abstract:
:The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated as a dynamic bioactive agent. Over two decades of research has begun to characterize various regulatory roles for C1P from mammalian inflammatory response and wound healing to cellular proliferation and survival. As a metabolite of the intricately balanced "sphingolipid rheostat", C1P stands as a crucial physiological regulator of both upstream and downstream mechanisms. This chapter serves as an overview of established and implicated roles for C1P in cellular processes vital to diseases and mammalian physiology. Additionally, we discuss potential clinical roles for C1P in cancer treatment, wound therapy, and pre-disease diagnosis. While many questions remain regarding C1P metabolism and the extent of signaling factors targeted by this bioactive lipid, new technologies and methodologies show great promise to discern key targets, signaling pathways, and physiologies regulated by C1P.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Berwick ML,Dudley BA,Maus K,Chalfant CEdoi
10.1007/978-3-030-21162-2_5subject
Has Abstractpub_date
2019-01-01 00:00:00pages
65-77eissn
0065-2598issn
2214-8019journal_volume
1159pub_type
杂志文章,评审abstract::Insufficient oxygen delivery and retinal hypoxia have been implicated as causal in the development of many devastating diseases of the eye. While the two-dimensional imaging of retinal oxygen tension (PO2) has now been applied in a variety of different animal models, it is fundamentally a luminescence-based system lac...
journal_title:Advances in experimental medicine and biology
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更新日期:2018-01-01 00:00:00
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