Abstract：
:TRPV1 is a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons, and act as an important signal integrator in sensory nociceptors. Because of its integrative signaling properties in response to inflammatory stimuli, TRPV1 antagonists are predicted to inhibit the sensation of ongoing or burning pain that is reported by patients suffering from chronic pain, therefore offering an unprecedented advantage in selectively inhibiting painful signaling from where it is initiated. In this chapter, we firstly summarize the physiological and pathological roles of TRPV1 and then describe the pharmacology of TRPV1 agonists and antagonists. Finally, we give an update and the status on TRPV1 therapies that have progressed into clinical trials.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Xia R,Dekermendjian K,Lullau E,Dekker Ndoi
10.1007/978-94-007-0265-3_34subject
Has Abstractpub_date
2011-01-01 00:00:00pages
637-65eissn
0065-2598issn
2214-8019journal_volume
704pub_type
杂志文章,评审abstract：:Epidemiologic evidence in humans and controlled trials in animal models indicate that total dietary fat increases the risk of cancer. The animal evidence indicates that the greatest efficacy in promoting carcinogenesis is achieved with omega-6 fatty acids with little or no effect from either the omega-3 or monounsatur...
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更新日期：2017-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
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更新日期：2006-01-01 00:00:00
