Abstract:
:Doxorubicin is an anthracycline and one of the more effective chemotherapy agents used in the treatment of children, adolescents, and adults with osteosarcoma. Despite its effectiveness, cardiotoxicity is a major late effect that compromises the survival and quality of life of survivors of this and other cancers. Cardiotoxicity is the inability of the heart to pump blood through the body effectively. Doxorubicin-induced cardiotoxicity is dose dependent. Additionally, the age of the patients plays a role in susceptibility with younger patients having a greater risk for cardiotoxicity and heart failure years after treatment is complete. The exact mechanism(s) responsible for doxorubicin-induced cardiotoxicity is poorly understood, and further research needs to be done to elucidate the mechanisms. This chapter summarizes the identified mechanisms that may play a role in anthracycline-induced cardiotoxicity. We will also summarize the types of cardiomyopathies that have been described in survivors treated with doxorubicin and the current recommendations for monitoring survivor for the development of cardiomyopathies. Included will be the important search for defining early biomarkers to identify patients and survivors at risk. Finally, we will summarize some of the interventions proposed for decreasing anthracycline-induced cardiotoxicity.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Bhagat A,Kleinerman ESdoi
10.1007/978-3-030-43032-0_15subject
Has Abstractpub_date
2020-01-01 00:00:00pages
181-192eissn
0065-2598issn
2214-8019journal_volume
1257pub_type
杂志文章,评审abstract::The immune response to insulin, in both mouse and guinea pig , is under control of H-linked immune response genes. When immunized with either pork or beef insulin to CFA, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. The specificity of the eli...
journal_title:Advances in experimental medicine and biology
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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doi:10.1007/978-1-4939-2981-8_73
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journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
doi:10.1007/978-1-4757-1419-7_25
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pub_type: 杂志文章
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pub_type: 杂志文章
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