Abstract:
:The transcription factor CUTL1 (CCAAT displacement protein 1) has been reported to participate in the proliferation of diverse types of cancer. In the present study, we investigated the potential involvement of CUTL1 in the proliferation of malignant melanoma. We found that CUTL1 expression was upregulated in malignant melanoma tissues and cell lines, and CUTL1 expression was selected as a prognostic predictor for malignant melanoma patients by both univariate and multivariate analysis. Knockdown of CUTL1 by short hairpin RNA significantly reduced the colony-forming ability of malignant melanoma cells in vitro and reduced tumor growth in vivo, whereas forced overexpression of CUTL1 produced the opposite results. Consistently, cell cycle progression was impaired upon downregulation of CUTL1 and enhanced when CUTL1 was upregulated. Additional experiments suggested that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Fan X,Wang H,Zhou J,Wang S,Zhang X,Li T,Nie Y,Liu Bdoi
10.1097/CMR.0000000000000064subject
Has Abstractpub_date
2014-06-01 00:00:00pages
198-206issue
3eissn
0960-8931issn
1473-5636journal_volume
24pub_type
杂志文章abstract::The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200106000-00003
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000112
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journal_title:Melanoma research
pub_type: 杂志文章,评审
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000063
更新日期:2014-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3280141617
更新日期:2007-02-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32831bc44a
更新日期:2009-08-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200110000-00002
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pub_type: 杂志文章
doi:10.1097/00008390-199902000-00013
更新日期:1999-02-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
doi:10.1097/00008390-199306000-00005
更新日期:1993-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200204000-00006
更新日期:2002-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200012000-00010
更新日期:2000-12-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/CMR.0b013e32832eabd5
更新日期:2009-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200302000-00014
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200504000-00001
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