Lovastatin-induced apoptosis in human melanoma cell lines.

abstract：:The CXCR4 chemokine receptor plays an essential role in the homing of cells to organs expressing its ligand, CXCL12. CXCR4 expressed on tumor cells might regulate their traffic during metastasis. Here, we investigated whether the activation of CXCR4 on B16 murine melanoma cells regulates biological functions associate...

journal_title：Melanoma research

authors： Mendt M,Cardier JE

更新日期：2017-08-01 00:00:00

abstract：:Pigmented basal cell carcinoma (PBCC) is a tumour with distinct clinical features which occasionally may be difficult to differentiate from malignant melanoma (MM). The purpose of this study was to re-examine the epiluminescence microscopy (ELM) criteria for PBCC and to determine their statistical significance in the ...

journal_title：Melanoma research

authors： Püspök-Schwarz M,Steiner A,Binder M,Partsch B,Wolff K,Pehamberger H

更新日期：1997-08-01 00:00:00

abstract：:The nm23 gene is a putative tumour and metastasis suppressor gene. A number of studies have found that reduction of its expression is associated with increased metastatic potential in several human malignancies. Similarly, clinical studies have shown correlation between reduced nm23 protein expression and a poor progn...

journal_title：Melanoma research

authors： Sarris M,Scolyer RA,Konopka M,Thompson JF,Harper CG,Lee CS

更新日期：2004-02-01 00:00:00

abstract：:There is no general consensus regarding the optimal follow-up strategy for patients with melanoma. We sought to determine the utility and cost effectiveness of radiological restaging of patients with stage IIB-IIIC melanoma at the 3-year follow-up time point. A retrospective review of 210 patients diagnosed with stage...

journal_title：Melanoma research

authors： DeRose ER,Pleet A,Wang W,Seery VJ,Lee MY,Renzi S,Sullivan RJ,Atkins MB

更新日期：2011-08-01 00:00:00

abstract：:Several hypotheses have explicitly implicated the role of an altered redox status of melanin in the aetiology of melanoma and macular degeneration. The balance between the intrinsic anti-oxidant and pro-oxidant properties of melanin is lost, resulting in an altered redox phenotype. We propose that such an alteration o...

journal_title：Melanoma research

authors： Sarangarajan R,Apte SP

更新日期：2006-02-01 00:00:00

abstract：:The proto-oncogene c-Kit encodes a membrane receptor protein with intrinsic tyrosine kinase activity. Activation of c-Kit induces cell proliferation, differentiation or migration among different cell types. The present study provides evidence that c-Kit plays an important role in the cell differentiation rather than i...

journal_title：Melanoma research

authors： Luo D,Chen H,Searles G,Jimbow K

更新日期：1995-10-01 00:00:00

abstract：:Paraffin-embedded tissue from the primary tumours of 116 patients with malignant melanoma, and in 40 cases also from corresponding metastases, were examined for accumulation of p53 protein. The fraction of tumours with positive p53 immunostaining was 13% in the least invasive and 36% in the most invasive primary lesio...

journal_title：Melanoma research

authors： Flørenes VA,Holm R,Fodstad O

更新日期：1995-06-01 00:00:00

abstract：:The National Comprehensive Cancer Network has formulated guidelines for the management of cutaneous malignant melanoma with regard to resection margins (RMs) and regional staging. The aim of this study was to assess compliance with these recommendations in the general population of the USA. The Surveillance, Epidemiol...

journal_title：Melanoma research

authors： Wasif N,Gray RJ,Bagaria SP,Pockaj BA

更新日期：2013-08-01 00:00:00

abstract：:This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germa...

journal_title：Melanoma research

authors： Autier P,Doré JF,Lejeune F,Koelmel KF,Geffeler O,Hille P,Cesarini JP,Liénard D,Liabeuf A,Joarlette M

更新日期：1994-04-01 00:00:00

abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

journal_title：Melanoma research

authors： Yin G,Guo W,Chen X,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...

journal_title：Melanoma research

authors： Garbe C,Hauschild A,Volkenandt M,Schadendorf D,Stolz W,Reinhold U,Kortmann RD,Kettelhack C,Frerich B,Keilholz U,Dummer R,Sebastian G,Tilgen W,Schuler G,Mackensen A,Kaufmann R

更新日期：2008-02-01 00:00:00

abstract：:The incidence of melanoma has increased continuously during the last decade. Surgery is the mainstay of therapy but, for patients with thick lesions or regional metastatic lymph nodes, there is a high risk of relapse. For this group of patients, there is no standard therapy or general agreement amongst oncologists. In...

journal_title：Melanoma research

authors： Queirolo P,Acquati M,Kirkwood JM,Eggermont AM,Rocca A,Testori A

更新日期：2005-10-01 00:00:00

abstract：:The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of ...

journal_title：Melanoma research

authors： Kleemann J,Hrgovic I,Ter-Nedden J,Kleimann P,Steinhorst K,Härle K,Müller J,Kaufmann R,Meissner M,Kippenberger S

更新日期：2018-08-01 00:00:00

abstract：:Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...

journal_title：Melanoma research

authors： Saraiva VS,Marshall JC,Cools-Lartigue J,Burnier MN Jr

更新日期：2004-10-01 00:00:00

abstract：:Before licensing, ipilimumab was first made available to previously treated advanced melanoma patients through an expanded access programme (EAP) across Europe. We interrogated data from UK EAP patients to inform future clinical practice. Clinicians registered in the UK EAP provided anonymized patient data using a pre...

journal_title：Melanoma research

authors： Ahmad SS,Qian W,Ellis S,Mason E,Khattak MA,Gupta A,Shaw H,Quinton A,Kovarikova J,Thillai K,Rao A,Board R,Nobes J,Dalgleish A,Grumett S,Maraveyas A,Danson S,Talbot T,Harries M,Marples M,Plummer R,Kumar S,Nathan

更新日期：2015-10-01 00:00:00

abstract：:We studied the response of mouse B16F10 and SK-MEL-28 and SK-MEL-1 human melanoma cell lines to treatment with 4-hydroxyanisole (4-HA), and attempted to relate the response to the dopa oxidase levels and the morphological characteristics of each cell line. Clear dose-response curves were observed after 24 h of treatme...

journal_title：Melanoma research

authors： Rodriguez-Vicente J,Vicente-Ortega V,Canteras-Jordana M,Calderon-Rubiales F

更新日期：1997-10-01 00:00:00

abstract：:In this study we evaluated the overexpression status of HER-2 and its prognostic significance on survival in patients with thick cutaneous malignant melanoma. The immuno-alkaline phosphatase antigen detection technique was applied to archival diagnostic material from 51 patients with primary lesions measuring >or= 10 ...

journal_title：Melanoma research

authors： Eliopoulos P,Mohammed MQ,Henry K,Retsas S

更新日期：2002-04-01 00:00:00

abstract：:MAGE proteins have been identified as potential specific targets for cancer vaccination. Although MAGE-6 and MAGE-12 were originally identified in malignant melanoma there are no studies reporting the frequency of expression of these antigens in this malignancy. These are of relevance particularly for MAGE-6 as recent...

journal_title：Melanoma research

authors： Gibbs P,Hutchins AM,Dorian KT,Vaughan HA,Davis ID,Silvapulle M,Cebon JS

更新日期：2000-06-01 00:00:00

abstract：:The occurrence of cancer in pregnant women is not a common phenomenon and the real incidence of malignant melanoma during this period is unknown. Many authors reported a poor prognosis in pregnant women with melanoma compared with non-pregnant women's tumour. Several retrospective reviews reported a worsened prognosis...

journal_title：Melanoma research

authors： Silipo V,De Simone P,Mariani G,Buccini P,Ferrari A,Catricala C

更新日期：2006-12-01 00:00:00

abstract：:Conditional survival in patients with localized primary cutaneous malignant melanoma (CMM) is well described. However, conditional recurrence-free survival (RFS) has not been investigated before. The aim of this study was to determine conditional RFS and test for time dependency in prognostic factors in patients with ...

journal_title：Melanoma research

authors： Lyth J

更新日期：2018-12-01 00:00:00

abstract：:In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed a...

journal_title：Melanoma research

authors： Wu C,Li X,Tian M

更新日期：2005-06-01 00:00:00

abstract：:Melanoma is one of the most common cancers worldwide and its incidence has been increasing over the past few decades. Gallic acid (GA) can inhibit the growth of human cancer cells in vitro and in vivo. However, there is no available information to address the effects of GA on migration and invasion of human skin cance...

journal_title：Melanoma research

authors： Lo C,Lai TY,Yang JS,Yang JH,Ma YS,Weng SW,Lin HY,Chen HY,Lin JG,Chung JG

更新日期：2011-08-01 00:00:00

abstract：:Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatmen...

journal_title：Melanoma research

authors： Cahill RA,McGreal G,Neary P,Redmond HP

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic m...

journal_title：Melanoma research

authors： Rambhia PH,Honda K,Arbesman J

更新日期：2018-10-01 00:00:00

abstract：:Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...

journal_title：Melanoma research

authors： Ellerhorst JA,Cooksley CD,Grimm EA

更新日期：2001-12-01 00:00:00

abstract：:In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study. Twenty patients with melanoma metastases of skin and soft tissues, eventually also of the lung, who were treated with syste...

journal_title：Melanoma research

authors： von Stamm U,Bröcker EB,von Depka Prondzinski M,Ruiter DJ,Rümke P,Broding C,Carrel S,Lejeune FJ

更新日期：1993-06-01 00:00:00

abstract：:The presence or absence of melanoma cells in human peripheral blood has recently been shown to be associated with disease prognosis, including overall survival. The detection of tyrosinase mRNA-positive circulating melanoma cells by reverse transcription-polymerase chain reaction (RT-PCR) has been limited to dissemina...

journal_title：Melanoma research

authors： Schrader AJ,Probst-Kepper M,Grosse J,Kunter U,Schenk F,Franzke A,Atzpodien J,Buer J

更新日期：2000-08-01 00:00:00

abstract：:Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The extracts producing singlet oxygen were then evaluated for cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines using the 3-[4,5-dimeth...

journal_title：Melanoma research

authors： Aydoğmuş-Öztürk F,Günaydin K,Öztürk M,Jahan H,Duru ME,Choudhary MI

更新日期：2018-12-01 00:00:00