Abstract:
:This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germany, France and Belgium. Four-hundred and twenty consecutive patients with CMM diagnosed from 1 January 1991 on were derived from hospital registries; 447 controls were chosen randomly in the same municipality as cases. Subjects unaware of the dangers of exaggerated exposure to sunlight display an estimated CMM risk of 3.72% (95% confidence interval 2.63-5.26). The number of holiday weeks spent annually in sunny resorts and sunbathing during the hot hours of the day are strong risk factors in the three countries, but not the number of years spent outdoors, as farmers or building workers. Multiple logistic adjustments on the host characteristics increases the CMM risk associated with recreational exposure to sunlight, as well as the adjustment on the unawareness of the dangers of exaggerated exposure to sunlight. Recreational exposure to sunlight and sunburn early in life seem capable of fostering the proliferation of pigmented lesions of the skin. Our data support the hypothesis that most CMM develop from pigmented lesions of the skin containing initiated melanocytes, and that the cell proliferation due to brutal, intermittent exposures to solar radiation amplifies the likelihood of a melanocyte entering into a malignant process.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Autier P,Doré JF,Lejeune F,Koelmel KF,Geffeler O,Hille P,Cesarini JP,Liénard D,Liabeuf A,Joarlette Mdoi
10.1097/00008390-199404000-00001subject
Has Abstract,Author List Incompletepub_date
1994-04-01 00:00:00pages
79-85issue
2eissn
0960-8931issn
1473-5636journal_volume
4pub_type
杂志文章,多中心研究abstract::Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based databa...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000245
更新日期:2016-08-01 00:00:00
abstract::The objective of this study was to identify novel tumor-suppressor genes in melanoma, using an integrative genomic approach. Data from: (i) earlier reports of DNA loss and gain in malignant melanoma accompanied by comparative genomic hybridization high-definition array data of the entire human genome; (ii) microarray ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328344a003
更新日期:2011-08-01 00:00:00
abstract::The objective of this study was to describe the risk factor profile of skin cancer screening participants and to determine whether there is an association between the number of skin cancer/melanoma risk factors and the likelihood of diagnosis of a malignant melanoma. Seventy skin cancer screening clinics were held by ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000205023.02527.ab
更新日期:2006-08-01 00:00:00
abstract::Dermoscopy is a non-invasive technique that can be utilized for the clinical diagnosis of pigmented lesions. The aim of this study was to assess the utilization and beliefs about the usefulness of dermoscopy in the evaluation of pigmented lesions by physicians in dermatology residency programmes, and to determine the ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200212000-00010
更新日期:2002-12-01 00:00:00
abstract::Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200410000-00014
更新日期:2004-10-01 00:00:00
abstract::Proteomics provides a powerful approach for screening alterations in protein expression and post-translational modification associated with particular human diseases. In this study, the analysis of protein expression was focused on malignant melanoma in order to determine the candidate genes involved in tumour progres...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200508000-00002
更新日期:2005-08-01 00:00:00
abstract::Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199604000-00007
更新日期:1996-04-01 00:00:00
abstract::The retinoblastoma protein (pRb) pathway is critical in regulating the G1 phase of the cell cycle and it is frequently disrupted in human cancers. Components of the pRb pathway which are often altered in tumour progression include the INK4 cyclin-dependent kinase (CDK) inhibitors p16INK4a/ CDKN2A and p15INK4b/CDKN2B, ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199902000-00003
更新日期:1999-02-01 00:00:00
abstract::A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated peptide with a xenogenic peptide (to promote ...
journal_title:Melanoma research
pub_type: 临床试验,杂志文章
doi:10.1097/CMR.0000000000000556
更新日期:2019-08-01 00:00:00
abstract::Patients with melanoma may experience a variety of different vision symptoms, in part associated with melanoma-associated retinopathy. For several melanoma patients with or without melanoma-associated retinopathy, colour vision deficiencies, especially involving the tritan system, have been reported. The frequency of ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000222599.35062.84
更新日期:2006-10-01 00:00:00
abstract::An inactive cathepsin B-like enzyme with a molecular mass of 40 kD was found in a human melanoma culture medium. The inactive form of this enzyme was converted into an active form with a molecular mass of 28 kD by pepsin treatment. This activated cathepsin B-like enzyme had almost the same characteristics regarding mo...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199201000-00005
更新日期:1992-01-01 00:00:00
abstract::We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melan...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000577
更新日期:2019-06-01 00:00:00
abstract::Paraffin-embedded tissue from the primary tumours of 116 patients with malignant melanoma, and in 40 cases also from corresponding metastases, were examined for accumulation of p53 protein. The fraction of tumours with positive p53 immunostaining was 13% in the least invasive and 36% in the most invasive primary lesio...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199506000-00007
更新日期:1995-06-01 00:00:00
abstract::The aim of this study was to present the epidemiological, clinicopathological, and treatment characteristics of patients diagnosed and treated in a tertiary referral center and to analyze independent factors associated with these characteristics. In this cohort study, epidemiological, clinicopathological, and treatmen...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000456
更新日期:2018-08-01 00:00:00
abstract::Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on thi...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000391
更新日期:2017-12-01 00:00:00
abstract::Recreational exposure to the sun may not explain fully current trends in melanoma incidence. The hypothesis was examined whether carcinogens in water play a role in the development of cutaneous melanoma. In a case-control study, 128 melanoma patients and 168 patients with other types of malignancy completed a detailed...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199410000-00002
更新日期:1994-10-01 00:00:00
abstract::Pelvic sentinel lymph nodes (SLNs) are commonly identified during inguinal SLN biopsy for melanoma, but retrieval is not uniform among surgeons/centers. Few studies have assessed rates of micrometastases in pelvic versus superficial inguinal SLNs. Previous studies suggested that presence of pelvic SLNs was predicted b...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000498
更新日期:2019-02-01 00:00:00
abstract::Locally advanced cutaneous melanoma has marked quality-of-life implications; however, the patient experience of symptom management and subsequent impact on quality of life has not been well described. This study aims to address the impact on patients of advanced cutaneous melanoma through qualitative interviews. Adult...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000425
更新日期:2018-04-01 00:00:00
abstract::Both in vitro and in vivo observations have suggested that melatonin modulates malignant cell growth. The present studies aimed to characterize the interactions of melatonin with cultured murine B16 melanoma cells. Time- and temperature-dependent specific melatonin accumulation by B16 murine melanoma cells was observe...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199311000-00003
更新日期:1993-12-01 00:00:00
abstract::Microphthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. We previously reported that Mitf expression, as detected by immunohistochemical analysis, is an independent prognostic marker in patients with intermediate-thickness melanoma. However, the clinical significance of Mit...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000195
更新日期:2015-12-01 00:00:00
abstract::Pregnancy-associated melanoma is defined as melanoma diagnosed during pregnancy or within 1 year of delivery. The association of pregnancy with melanoma is well known, but its underlying molecular mechanisms of association are poorly understood. The aim was to assess the expression of apoptosis-related genes in melano...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000452
更新日期:2018-08-01 00:00:00
abstract::Melanoma tumors have been shown to comprise both invasive and proliferative cell subpopulations. These populations are highly plastic, thus hampering full characterization and therapeutic targeting of dormant and partially dedifferentiated invasive cells. We have reported, previously, that melanoma cells grown in a se...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328351e7c4
更新日期:2012-06-01 00:00:00
abstract::The aim of this study was to evaluate the accuracy of a computer-based system for the automated diagnosis of melanoma in the hands of nonexpert physicians. We performed a prospective comparison between nonexperts using computer assistance and experts without assistance in the setting of a tertiary referral center at a...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32832a1e41
更新日期:2009-06-01 00:00:00
abstract::During the process of melanogenesis free radicals are generated. The aim of this study was to investigate the effects of melanogenesis in B16 melanoma on lipid peroxidation and antioxidant capacity in selected tissues of black C57BL/6J mice. The study was conducted on 24 mice: 12 healthy controls and 12 with a transpl...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200302000-00004
更新日期:2003-02-01 00:00:00
abstract::We examined the incidence of primary invasive melanoma in the municipality of Reggio Emilia, northern Italy, in the period from 1986 to 1997. We identified 169 cases, five of which were intraocular. After adjustment for confounders, the risk of having a thick melanoma (Breslow > or = 1 mm) did not decrease over time, ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199902000-00013
更新日期:1999-02-01 00:00:00
abstract::In a previous qualitative study it has been shown that the incorporation of pre-existing collagen bundles from the reticular dermis into the bulk of melanoma lesions metastatic to the skin indicates rapid systemic spread. In the present study the amount of pre-existing dermal collagen in the bulk of the melanoma lesio...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199804000-00010
更新日期:1998-04-01 00:00:00
abstract::Intercellular adhesion molecule (ICAM)-1 and mucin isotype MUC18 were originally identified as melanoma progression antigens by monoclonal antibodies (MAb) generated in a search for molecules expressed by melanomas but not detectable on benign naevi. As MAb detect single epitopes whose accessibility may be modulated, ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::The aim of this study was to determine the impact of complete response (CR) to systemic therapy on survival. We reviewed the cases of 647 chemo-naive patients with metastatic melanoma who were treated with cisplatin-vinblastine-dacarbazine or cisplatin-taxol-dacarbazine alone, or cisplatin-vinblastine-dacarbazine toge...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/CMR.0b013e328341445f
更新日期:2011-02-01 00:00:00
abstract::We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/CMR.0b013e32833faf6a
更新日期:2010-12-01 00:00:00