Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases.

abstract：:Patients with brain metastases (BM) from melanoma have an overall survival (OS) of 2-6 months after whole-brain radiotherapy. Targeted therapy (TT) is an effective treatment for BRAF-mutated metastatic melanoma. Moreover, recent studies indicate intracranial responses of TT in patients with BM. We analyzed 146 patient...

journal_title：Melanoma research

authors： Geukes Foppen MH,Boogerd W,Blank CU,van Thienen JV,Haanen JB,Brandsma D

更新日期：2018-04-01 00:00:00

abstract：:Checkpoint inhibitor immunotherapy is a transformative treatment for advanced malignancies, but can be associated with numerous immune-related adverse events (irAEs). The majority of irAEs include those that closely resemble known cutaneous and neurocutaneous autoimmune or autoinflammatory diseases, such as scleroderm...

journal_title：Melanoma research

authors： Kosche C,Stout M,Sosman J,Lukas RV,Choi JN

更新日期：2020-06-01 00:00:00

abstract：:Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...

journal_title：Melanoma research

authors： Avril MF,Chompret A,Verne-Fourment L,Terrier-Lacombe MJ,Spatz A,Fizazi K,Bressac-de Paillerets B,Demenais F,Théodore C

更新日期：2001-04-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:Galectin-9, a β-galactoside-binding protein, is defined as a negative regulator of T helper 1 (Th1) immune responses, favoring Th2 bias. Systemic immunity in patients with metastatic melanoma is predominantly Th2 biased. We hypothesized that galectin-9 can modulate systemic immunity toward Th2 polarization in patients...

journal_title：Melanoma research

authors： Enninga EA,Nevala WK,Holtan SG,Leontovich AA,Markovic SN

更新日期：2016-10-01 00:00:00

abstract：:Melan-A is widely used in the diagnostics of human melanoma. The immunogenicity of this glycoprotein makes it a potential target in immunotherapy and several authors have suggested its potential as a prognostic factor. Up to now there has been no clear direct evidence of changes of Melan-A expression during the progre...

journal_title：Melanoma research

authors： Sztramska A,Dymerska D,Chwirot BW

更新日期：2008-08-01 00:00:00

abstract：:We examined the incidence of primary invasive melanoma in the municipality of Reggio Emilia, northern Italy, in the period from 1986 to 1997. We identified 169 cases, five of which were intraocular. After adjustment for confounders, the risk of having a thick melanoma (Breslow > or = 1 mm) did not decrease over time, ...

journal_title：Melanoma research

authors： Vinceti M,Bergomi M,Borciani N,Serra L,Vivoli G

更新日期：1999-02-01 00:00:00

abstract：:The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between...

journal_title：Melanoma research

authors： Bellocq D,Roy P,Kodjikian L,Mathis T,Nguyen AM,Herault J,Rivoire M,Négrier S,Thariat J,Grange JD

更新日期：2020-06-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Recreational exposure to the sun may not explain fully current trends in melanoma incidence. The hypothesis was examined whether carcinogens in water play a role in the development of cutaneous melanoma. In a case-control study, 128 melanoma patients and 168 patients with other types of malignancy completed a detailed...

journal_title：Melanoma research

authors： Nelemans PJ,Rampen FH,Groenendal H,Kiemeney LA,Ruiter DJ,Verbeek AL

更新日期：1994-10-01 00:00:00

abstract：:Locally advanced cutaneous melanoma has marked quality-of-life implications; however, the patient experience of symptom management and subsequent impact on quality of life has not been well described. This study aims to address the impact on patients of advanced cutaneous melanoma through qualitative interviews. Adult...

journal_title：Melanoma research

authors： Weitman ES,Perez M,Thompson JF,Andtbacka RHI,Dalton J,Martin ML,Miller T,Gwaltney C,Sarson D,Wachter E,Zager JS

更新日期：2018-04-01 00:00:00

abstract：:Significant advances have been made in the treatment of melanoma by targeting key cellular pathways, but additional targets are needed as many patients do not respond or relapse with resistant disease. MicroRNA-155 (MiR-155) has previously been shown to regulate melanoma cell growth and acts as a tumor suppressor. We ...

journal_title：Melanoma research

authors： DiSano JA,Huffnagle I,Gowda R,Spiegelman VS,Robertson GP,Pameijer CR

更新日期：2019-04-01 00:00:00

abstract：:Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on thi...

journal_title：Melanoma research

authors： de Souza Neto FP,Bernardes SS,Marinello PC,Melo GP,Luiz RC,Cecchini R,Cecchini AL

更新日期：2017-12-01 00:00:00

abstract：:Sentinel lymph node dissection (SLND) identifies melanoma patients with metastatic disease who would benefit from radical lymph node dissection (RLND). Rarely, patients with melanoma have an underlying lymphoproliferative disease, and melanoma metastases might develop as collision tumours in the sentinel lymph node (S...

journal_title：Melanoma research

authors： Gero D,Queiros da Mota V,Boubaker A,Berthod G,de Leval L,Demartines N,Matter M

更新日期：2014-08-01 00:00:00

abstract：:The liver is the predominant site of metastases in the majority of patients with uveal melanoma, suggesting the evaluation of regional treatment approaches. Here we report our experience with transarterial chemoembolization (TACE) in uveal melanoma patients with pretreated liver metastases. Twenty-five patients were t...

journal_title：Melanoma research

authors： Schuster R,Lindner M,Wacker F,Krössin M,Bechrakis N,Foerster MH,Thiel E,Keilholz U,Schmittel A

更新日期：2010-06-01 00:00:00

abstract：:Studies on cytogenetic abnormalities and cell lines have implicated chromosome 1p32 as being important in the pathogenesis of melanoma. Genetic linkage studies have also mapped a melanoma-susceptibility locus to chromosome 1p. The gene TAL1 is present on chromosome 1p32, and deletions within it are the commonest chrom...

journal_title：Melanoma research

authors： Chetty R,Cerroni L,Pulford K,Giatromanolaki A,Biddolph S,Kaklamanis L,Gatter K

更新日期：1995-08-01 00:00:00

abstract：:In metastatic melanoma (MM) immunomodulating agents, such as interleukin-2 (IL-2) and interferon-α (IFN-α), have shown therapeutic benefit as they enhance antitumor immune response. Considering tumor-induced suppression of natural killer (NK) cell activity, it is of interest to study the affect of these cytokines on t...

journal_title：Melanoma research

authors： Konjević G,Mirjačić Martinović K,Vuletić A,Babović N

更新日期：2010-12-01 00:00:00

abstract：:M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the relationship with tumor progression and known prognostic parameters. Fifty-...

journal_title：Melanoma research

authors： Tas F,Karabulut S,Serilmez M,Yildiz I,Sen F,Ciftci R,Duranyildiz D

更新日期：2013-10-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agen...

journal_title：Melanoma research

authors： Heller R,Jaroszeski M,Perrott R,Messina J,Gilbert R

更新日期：1997-02-01 00:00:00

abstract：:Pelvic sentinel lymph nodes (SLNs) are commonly identified during inguinal SLN biopsy for melanoma, but retrieval is not uniform among surgeons/centers. Few studies have assessed rates of micrometastases in pelvic versus superficial inguinal SLNs. Previous studies suggested that presence of pelvic SLNs was predicted b...

journal_title：Melanoma research

authors： Swords DS,Andtbacka RHI,Bowles TL,Hyngstrom JR

更新日期：2019-02-01 00:00:00

abstract：:Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatmen...

journal_title：Melanoma research

authors： Cahill RA,McGreal G,Neary P,Redmond HP

更新日期：2001-10-01 00:00:00

abstract：:Therapeutic failures in cancer therapy are often associated with metabolic plasticity. The use of metabolic modulators as anti-cancer agents has been effective in correcting metabolic alterations; however, molecular events behind metabolic switch are still largely unexplored. Herein, we characterize the molecular and ...

journal_title：Melanoma research

authors： Pistoni M,Tondelli G,Gallo C,Torricelli F,Maresca A,Carelli V,Ciarrocchi A,Dallaglio K

更新日期：2020-02-01 00:00:00

abstract：:Concurrent BRAF-MEK inhibition improves clinical outcomes in patients with advanced BRAF V600E/K-mutant melanoma. There is currently less evidence for the efficacy of this treatment in patients with rare BRAF non-V600E/K genotypes. We report on two patients with rare BRAF exon 15 mutations - BRAF A598_T599insV and V60...

journal_title：Melanoma research

authors： Rogiers A,Vander Borght S,Tuand K,Wolter P,Stas M,Boecxstaens V,Garmyn M,van den Oord JJ,Vandenberghe P,Bechter O

更新日期：2017-10-01 00:00:00

abstract：:The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

journal_title：Melanoma research

authors： Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

更新日期：1997-12-01 00:00:00

abstract：:Appropriate margins of excision for melanoma have been well defined on the basis of prospective clinical trials. Various factors may result in a discrepancy between the intended clinical margin and the pathologic margin ex vivo, however, making it difficult to determine whether adequate excision margins have been obta...

journal_title：Melanoma research

authors： Clausen SP,Brady MS

更新日期：2005-12-01 00:00:00

abstract：:Melanoma is the deadliest form of skin cancer. Ipilimumab, a novel immunotherapy, is the first treatment shown to improve survival in patients with metastatic melanoma in large randomized controlled studies. The most concerning side effects reported in clinical studies of ipilimumab fall into the category of immune-re...

journal_title：Melanoma research

authors： Bernardo SG,Moskalenko M,Pan M,Shah S,Sidhu HK,Sicular S,Harcharik S,Chang R,Friedlander P,Saenger YM

更新日期：2013-02-01 00:00:00

abstract：:Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique is potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen patient...

journal_title：Melanoma research

authors： Byrne CM,Thompson JF,Johnston H,Hersey P,Quinn MJ,Michael Hughes T,McCarthy WH

更新日期：2005-02-01 00:00:00

abstract：:Cell clones derived from a human melanoma metastasis selected for different integrin profiles were examined in vitro for invasive potential and biological and biochemical features potentially related to this process. Clones which expressed high levels of integrins showed high invasive potential, extracellular matrix d...

journal_title：Melanoma research

authors： Supino R,Mapelli E,Sanfilippo O,Silvestro L

更新日期：1992-12-01 00:00:00

abstract：:Superantigens like the Staphylococcus enterotoxin A (SEA) can direct cytotoxic T lymphocytes expressing certain T cell receptor V beta regions to lyse MHC class II-positive target cells. This superantigen-dependent cellular cytotoxicity (SDCC) has been extended to MHC class II-negative tumour cells by targeting T cell...

journal_title：Melanoma research

authors： Krull F,Holzer U,Ihle J,Bethge W,Fierlbeck G,Kalland T,Dohlsten M,Niethammer D,Dannecker GE

更新日期：1997-06-01 00:00:00