Metformin: oxidative and proliferative parameters in-vitro and in-vivo models of murine melanoma.

abstract：:Selective sentinel lymph node (SLN) dissection is widely used in the management of cutaneous melanoma patients without clinical evidence of nodal metastases. A series of 274 consecutive melanoma patients who underwent melanoma primary excision and SLN mapping at our institutions since 1998, and were thereafter followe...

journal_title：Melanoma research

authors： Macripò G,Quaglino P,Caliendo V,Ronco AM,Soltani S,Giacone E,Pau S,Fierro MT,Bernengo MG

更新日期：2004-04-01 00:00:00

abstract：:Selective inhibition of the mutant BRAF protein is a highly promising therapeutic approach for melanoma patients carrying the BRAF mutation. Despite the remarkable clinical response, most patients develop resistance and experience tumour regrowth. To clarify the molecular background of BRAF inhibitor resistance, we ge...

journal_title：Melanoma research

authors： Szász I,Koroknai V,Kiss T,Vízkeleti L,Ádány R,Balázs M

更新日期：2019-08-01 00:00:00

abstract：:Seasonal variation in melanoma diagnoses has been observed in numerous studies that used calendar time indicators. Depending on the latitude (and altitude) of the study region, the magnitude of seasonal and year-to-year variation of ultraviolet radiation (UVR) is neglected in these studies. An alternative approach com...

journal_title：Melanoma research

authors： Keller AK,Uter W,Pfahlberg AB,Radespiel-Tröger M,Mayer I,Gefeller O

更新日期：2015-12-01 00:00:00

abstract：:Metabolic imaging with F-18 fluorodeoxy-D-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. We designed, in 2004, at the Institute Gustave Roussy, a prospective study to determine the value of F-18 fluorodeoxy-D-glucose positron emission t...

journal_title：Melanoma research

authors： Maubec E,Lumbroso J,Masson F,Suciu V,Kolb F,Mamelle G,Cavalcanti A,Boitier F,Spatz A,Aupérin A,Leboulleux S,Avril MF

更新日期：2007-06-01 00:00:00

abstract：:In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study. Twenty patients with melanoma metastases of skin and soft tissues, eventually also of the lung, who were treated with syste...

journal_title：Melanoma research

authors： von Stamm U,Bröcker EB,von Depka Prondzinski M,Ruiter DJ,Rümke P,Broding C,Carrel S,Lejeune FJ

更新日期：1993-06-01 00:00:00

abstract：:There is no general consensus regarding the optimal follow-up strategy for patients with melanoma. We sought to determine the utility and cost effectiveness of radiological restaging of patients with stage IIB-IIIC melanoma at the 3-year follow-up time point. A retrospective review of 210 patients diagnosed with stage...

journal_title：Melanoma research

authors： DeRose ER,Pleet A,Wang W,Seery VJ,Lee MY,Renzi S,Sullivan RJ,Atkins MB

更新日期：2011-08-01 00:00:00

abstract：:Appropriate margins of excision for melanoma have been well defined on the basis of prospective clinical trials. Various factors may result in a discrepancy between the intended clinical margin and the pathologic margin ex vivo, however, making it difficult to determine whether adequate excision margins have been obta...

journal_title：Melanoma research

authors： Clausen SP,Brady MS

更新日期：2005-12-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:To study the mechanisms by which insulin regulates proliferation, we have compared wild-type Cloudman melanoma cells, whose growth in inhibited by insulin (insinh) to variant lines that were genetically selected for resistance to insulin (insres). Scatchard analysis of insulin binding to five insres) lines and six ins...

journal_title：Melanoma research

authors： Slominski A,McNeely T,Pawelek J

更新日期：1992-07-01 00:00:00

abstract：:Malignant melanoma is a cancer whose incidence is rising rapidly. Extensive studies of primary tumors and tumor-derived cell lines revealed that inappropriate activation of signal transducer and activator of transcription (STAT) proteins, particularly of STAT3 and 5, occurs with high frequency in various human cancers...

journal_title：Melanoma research

authors： Hassel JC,Winnemöller D,Schartl M,Wellbrock C

更新日期：2008-12-01 00:00:00

abstract：:Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...

journal_title：Melanoma research

authors： Sztiller-Sikorska M,Koprowska K,Jakubowska J,Zalesna I,Stasiak M,Duechler M,Czyz ME

更新日期：2012-06-01 00:00:00

abstract：:The cell surface glycoprotein MUC18 was originally identified as a progression associated antigen in melanoma. MUC18 is expressed most strongly on metastatic lesions and advanced primary tumours and is only rarely detected in benign lesions. cDNA cloning revealed MUC18 to be a novel member of the immunoglobulin superf...

journal_title：Melanoma research

authors： Johnson JP,Rothbächer U,Sers C

更新日期：1993-10-01 00:00:00

abstract：:Interleukin-8 (IL-8) is a cytokine that is thought to promote melanoma tumour progression. We evaluated and adapted a non-radioactive, reverse transcriptase-polymerase chain reaction method for semiquantitative analysis of IL-8 mRNA expression. Using this technique we studied the regulation of IL-8 levels in the melan...

journal_title：Melanoma research

authors： Möhler T,Scheibenbogen C,Häfele J,Willhauck M,Keilholz U

更新日期：1996-08-01 00:00:00

abstract：:The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...

journal_title：Melanoma research

authors： Zukauskaite R,Schmidt H,Asmussen JT,Hansen O,Bastholt L

更新日期：2013-02-01 00:00:00

abstract：:In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed a...

journal_title：Melanoma research

authors： Wu C,Li X,Tian M

更新日期：2005-06-01 00:00:00

abstract：:The CXCR4 chemokine receptor plays an essential role in the homing of cells to organs expressing its ligand, CXCL12. CXCR4 expressed on tumor cells might regulate their traffic during metastasis. Here, we investigated whether the activation of CXCR4 on B16 murine melanoma cells regulates biological functions associate...

journal_title：Melanoma research

authors： Mendt M,Cardier JE

更新日期：2017-08-01 00:00:00

abstract：:Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based databa...

journal_title：Melanoma research

authors： Singh P,Kim HJ,Schwartz RA

更新日期：2016-08-01 00:00:00

abstract：:Superantigens like the Staphylococcus enterotoxin A (SEA) can direct cytotoxic T lymphocytes expressing certain T cell receptor V beta regions to lyse MHC class II-positive target cells. This superantigen-dependent cellular cytotoxicity (SDCC) has been extended to MHC class II-negative tumour cells by targeting T cell...

journal_title：Melanoma research

authors： Krull F,Holzer U,Ihle J,Bethge W,Fierlbeck G,Kalland T,Dohlsten M,Niethammer D,Dannecker GE

更新日期：1997-06-01 00:00:00

abstract：:Little population-based data has been published about skin cancers in children and young adults. In this study, 200 cases of melanoma and non-melanoma skin cancers diagnosed under 25 years of age in the North of England from 1968-1995 were obtained from the Northern Region Young Persons' Malignant Disease Registry. Th...

journal_title：Melanoma research

authors： Pearce MS,Parker L,Cotterill SJ,Gordon PM,Craft AW

更新日期：2003-08-01 00:00:00

abstract：:Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...

journal_title：Melanoma research

authors： Danen EH,de Vries TJ,Morandini R,Ghanem GG,Ruiter DJ,van Muijen GN

更新日期：1996-04-01 00:00:00

abstract：:In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have ge...

journal_title：Melanoma research

authors： Wind TT,Gacesa R,Vich Vila A,de Haan JJ,Jalving M,Weersma RK,Hospers GAP

更新日期：2020-06-01 00:00:00

abstract：:Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The extracts producing singlet oxygen were then evaluated for cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines using the 3-[4,5-dimeth...

journal_title：Melanoma research

authors： Aydoğmuş-Öztürk F,Günaydin K,Öztürk M,Jahan H,Duru ME,Choudhary MI

更新日期：2018-12-01 00:00:00

abstract：:Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed all t...

journal_title：Melanoma research

authors： Beninato T,Fucà G,Di Guardo L,Vetrano I,Valeri B,Nesa F,Del Vecchio M,Cimminiello C

更新日期：2021-01-22 00:00:00

abstract：:The mechanism of action of fotemustine, a relatively new chloroethylnitrosourea, was evaluated in human melanoma cells in order to assess its potential as an agent for hyperthermic limb perfusion. Fotemustine was more toxic to O6-alkylguanine methyl transferase (AGT) deficient (Mer-) cells than Mer+ cells, implicating...

journal_title：Melanoma research

authors： Hayes MT,Bartley J,Parsons PG

更新日期：1998-02-01 00:00:00

abstract：:When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated and injected into subjects, long-term antitumour immunity is induced. Optimally, existing melanomas induced to produce cytokines in vivo could stimulate this same immune response. Although in vivo electroporation enha...

journal_title：Melanoma research

authors： Heller L,Pottinger C,Jaroszeski MJ,Gilbert R,Heller R

更新日期：2000-12-01 00:00:00

abstract：:Single-agent anti-PD1 antibodies are usually very well tolerated, but serious toxicity can still occur. Despite the PD-1 pathway seems to be relevant in the pathogenesis of immune-related myositis, anti-PD1-related myositis is generally a rare side effect of the treatment and usually not serious. However, its frequenc...

journal_title：Melanoma research

authors： Liu WK,Naban N,Kaul A,Patel N,Fusi A

更新日期：2021-02-01 00:00:00

abstract：:Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...

journal_title：Melanoma research

authors： Ulmer A,Metzger S,Fierlbeck G

更新日期：2002-08-01 00:00:00

abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...

journal_title：Melanoma research

authors： Abbott JL,Qureshi MM,Truong MT,Sahni D

更新日期：2019-08-01 00:00:00

abstract：:Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...

journal_title：Melanoma research

authors： Sorich MJ,Rowland A,Hopkins AM

更新日期：2020-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melano...

journal_title：Melanoma research

authors： Glud M,Manfé V,Biskup E,Holst L,Dirksen AM,Hastrup N,Nielsen FC,Drzewiecki KT,Gniadecki R

更新日期：2011-06-01 00:00:00