Abstract:
:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader population who could not previously afford this kind of travel. The purpose of this study was to analyse the correlation between increasing accessibility to air travel and melanoma incidence. This ecological study surveyed air travel patterns and melanoma incidence over the past three decades. Melanoma age-adjusted incidence was obtained from the United States Surveillance, Epidemiology, and End Results 9 Registry Database, 1975-2000, and the Cancer Registry of Norway, 1965-2000. United States mean inflation-adjusted airfare prices for four airports linked to leisure destinations (Miami, Los Angeles, San Diego, Phoenix) were compared with melanoma incidence. Parallel analyses were performed using annual domestic passenger-kilometres and melanoma incidence in Norway. Declining United States leisure-specific airfares corresponded strongly with increasing melanoma incidence (r = 0.96, r = 0.92, P < 0.001). Modelling a 5-year time lag between airfare and melanoma diagnosis strengthened the association (r = 0.98, r = 0.96, P < 0.001). Longer time lags could not be modelled due to data limitations. Data from Norway similarly showed that increasing air passenger mileage corresponded strongly with increasing melanoma incidence. Although correlation does not equate to causality, the very strong relationship between increasing access to air travel and melanoma incidence suggests that changes in recreational patterns may be contributing significantly to the public health problem of melanoma.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Agredano YZ,Chan JL,Kimball RC,Kimball ABdoi
10.1097/01.cmr.0000195696.50390.23subject
Has Abstractpub_date
2006-02-01 00:00:00pages
77-81issue
1eissn
0960-8931issn
1473-5636pii
00008390-200602000-00012journal_volume
16pub_type
杂志文章abstract::Interleukin-8 (IL-8) is a cytokine that is thought to promote melanoma tumour progression. We evaluated and adapted a non-radioactive, reverse transcriptase-polymerase chain reaction method for semiquantitative analysis of IL-8 mRNA expression. Using this technique we studied the regulation of IL-8 levels in the melan...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199608000-00005
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Melanoma research
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更新日期:2019-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3283364a37
更新日期:2010-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
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更新日期:1994-02-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200110000-00012
更新日期:2001-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32835ae915
更新日期:2013-02-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000205023.02527.ab
更新日期:2006-08-01 00:00:00
abstract::We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200412000-00009
更新日期:2004-12-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200510000-00011
更新日期:2005-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/00008390-200510000-00001
更新日期:2005-10-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328344958c
更新日期:2011-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200312000-00006
更新日期:2003-12-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200306000-00006
更新日期:2003-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200506000-00007
更新日期:2005-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000545
更新日期:2019-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
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更新日期:1996-06-01 00:00:00
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
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