Mutation analysis of candidate genes in melanoma-prone families: evidence of different pathogenetic mechanisms at chromosome 9P21.

abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...

journal_title：Melanoma research

authors： Abbott JL,Qureshi MM,Truong MT,Sahni D

更新日期：2019-08-01 00:00:00

abstract：:The p53 pathway regulates stress response, and variations in p53, MDM2, and MDM4 may predispose an individual to tumor development. The aim of this study was to study the impact of genetic variation on sporadic and hereditary melanoma. We have analyzed a combination of three functionally relevant variants of the p53 p...

journal_title：Melanoma research

authors： Thunell LK,Bivik C,Wäster P,Fredrikson M,Stjernström A,Synnerstad I,Rosdahl I,Enerbäck C

更新日期：2014-06-01 00:00:00

abstract：:Intercellular adhesion molecule (ICAM)-1 and mucin isotype MUC18 were originally identified as melanoma progression antigens by monoclonal antibodies (MAb) generated in a search for molecules expressed by melanomas but not detectable on benign naevi. As MAb detect single epitopes whose accessibility may be modulated, ...

journal_title：Melanoma research

authors： Kraus A,Masat L,Johnson JP

更新日期：1997-08-01 00:00:00

abstract：:Acral lentiginous melanoma (ALM) is the most frequent type of cutaneous melanoma in the Asian and African populations, but the fourth distinct variant of cutaneous melanoma in the Caucasian population. Histological criteria and prognosis of ALM remain controversial. A retrospective study, showing epidemiological, clin...

journal_title：Melanoma research

authors： Avilés-Izquierdo JA,Longo-Imedio MI,Lázaro-Ochaita P

更新日期：2010-06-25 00:00:00

abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...

journal_title：Melanoma research

authors： Guenova E,Lichte V,Hoetzenecker W,Woelbing F,Moehrle M,Roecken M,Schaller M

更新日期：2009-08-01 00:00:00

abstract：:Paraffin-embedded tissue from the primary tumours of 116 patients with malignant melanoma, and in 40 cases also from corresponding metastases, were examined for accumulation of p53 protein. The fraction of tumours with positive p53 immunostaining was 13% in the least invasive and 36% in the most invasive primary lesio...

journal_title：Melanoma research

authors： Flørenes VA,Holm R,Fodstad O

更新日期：1995-06-01 00:00:00

abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

journal_title：Melanoma research

authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

更新日期：2020-04-01 00:00:00

abstract：:Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...

journal_title：Melanoma research

authors： Danen EH,de Vries TJ,Morandini R,Ghanem GG,Ruiter DJ,van Muijen GN

更新日期：1996-04-01 00:00:00

abstract：:In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have ge...

journal_title：Melanoma research

authors： Wind TT,Gacesa R,Vich Vila A,de Haan JJ,Jalving M,Weersma RK,Hospers GAP

更新日期：2020-06-01 00:00:00

abstract：:Patients with melanoma may experience a variety of different vision symptoms, in part associated with melanoma-associated retinopathy. For several melanoma patients with or without melanoma-associated retinopathy, colour vision deficiencies, especially involving the tritan system, have been reported. The frequency of ...

journal_title：Melanoma research

authors： Pföhler C,Tschöp S,König J,Rass K,Tilgen W

更新日期：2006-10-01 00:00:00

abstract：:Proteomics provides a powerful approach for screening alterations in protein expression and post-translational modification associated with particular human diseases. In this study, the analysis of protein expression was focused on malignant melanoma in order to determine the candidate genes involved in tumour progres...

journal_title：Melanoma research

authors： Carta F,Demuro PP,Zanini C,Santona A,Castiglia D,D'Atri S,Ascierto PA,Napolitano M,Cossu A,Tadolini B,Turrini F,Manca A,Sini MC,Palmieri G,Rozzo AC,Italian Melanoma Intergroup.

更新日期：2005-08-01 00:00:00

abstract：:This study examines whether 6-thioguanine resistant T cells (mutant) from metastatic melanoma patients are enriched for melanoma-associated T cells compared to T cells obtained analogously without thioguanine selection (wild-type). Melanoma-associated antigen pentamer staining was performed on 5 tumour and 9 periphera...

journal_title：Melanoma research

authors： Zuleger CL,Newton MA,Ma X,Ong IM,Pei Q,Albertini MR

更新日期：2020-02-01 00:00:00

abstract：:The transcription factor CUTL1 (CCAAT displacement protein 1) has been reported to participate in the proliferation of diverse types of cancer. In the present study, we investigated the potential involvement of CUTL1 in the proliferation of malignant melanoma. We found that CUTL1 expression was upregulated in malignan...

journal_title：Melanoma research

authors： Fan X,Wang H,Zhou J,Wang S,Zhang X,Li T,Nie Y,Liu B

更新日期：2014-06-01 00:00:00

abstract：:Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which are applied directly to the tumour. The pulses facilitate delivery of drug through the plasma membrane. Enhanced delivery is rest...

journal_title：Melanoma research

authors： Jaroszeski MJ,Gilbert R,Perrott R,Heller R

更新日期：1996-12-01 00:00:00

abstract：:Several comparative genomic hybridization studies provide evidence for overrepresentation of the long arm of chromosome 20 in malignant melanoma. These studies also suggest that chromosome 20q contains genes that may contribute to melanoma pathogenesis. To refine the region of 20q amplification and to identify potenti...

journal_title：Melanoma research

authors： Koynova DK,Jordanova ES,Milev AD,Dijkman R,Kirov KS,Toncheva DI,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：:We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985. Computer linkage with a population-b...

journal_title：Melanoma research

authors： Rossing MA,Daling JR,Weiss NS,Moore DE,Self SG

更新日期：1995-04-01 00:00:00

abstract：:Melanomas are promising targets for immunotherapy, as they express a number of tissue-specific antigens against which immune responses can be elicited. We have previously described transgenic mice in which malignant cutaneous melanomas are produced. The 1042 melanoma cell line, derived from a primary melanoma in one o...

journal_title：Melanoma research

authors： Milling SW,Sai T,Silvers WK,Mintz B

更新日期：2004-12-01 00:00:00

abstract：:CD8 T-cell infiltration of metastatic melanoma may be a useful biomarker for prediction of prognosis and response to therapy. The heterogeneous distribution of CD8 T cells within a single tumor, and across different tumors within a single patient, may complicate quantification of infiltration. However, the impact of h...

journal_title：Melanoma research

authors： Obeid JM,Hu Y,Erdag G,Leick KM,Slingluff CL Jr

更新日期：2017-06-01 00:00:00

abstract：:The treatment of cancer during pregnancy presents a unique challenge. Optimal treatments are often altered or even delayed to protect fetal growth and organogenesis. The landscape of cancer treatment has shifted dramatically over the past several years and treatment with checkpoint inhibitors, including anti-PD1 and a...

journal_title：Melanoma research

authors： Bucheit AD,Hardy JT,Szender JB,Glitza Oliva IC

更新日期：2020-08-01 00:00:00

abstract：:Radiotherapy after lymph node dissection is recommended in high-risk melanoma cases. The aim of this study is to assess whether intensity-modulated radiotherapy (IMRT) offers advantages over three-dimensional conformal radiotherapy (3DCRT) in the groin nodal basin. Fifteen consecutively treated patients (5 3DCRT and 1...

journal_title：Melanoma research

authors： Adams G,Foote M,Brown S,Burmeister B

更新日期：2017-02-01 00:00:00

abstract：:We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...

journal_title：Melanoma research

authors： Valenzano Menada M,Moioli M,Garaventa A,Nozza P,Foppiano M,Trimarchi N,Fulcheri E

更新日期：2010-12-01 00:00:00

abstract：:Malignant melanoma is not only one of the most aggressive and lethal types of neoplasm, but its incidence in the general population is currently increasing at an alarming pace. It is interesting that most melanomas retain many of their characteristics of differentiation, including a dendritic nature and the production...

journal_title：Melanoma research

authors： Tsukamoto K,Gersten DM,Law LW,Hearing VJ

更新日期：1991-11-01 00:00:00

abstract：:Cell free extracts from metastases of human melanoma contain a highly active ribonucleoside diphosphate reductase (RR) which uses guanosine diphosphate (GDP) as substrate and deoxythymidine triphosphate (dTTP) as effector. No activity could be detected in these extracts when cytidine diphosphate (CDP) was used as the ...

journal_title：Melanoma research

authors： Schallreuter KU,Elgren TE,Nelson LS Jr,MacFarlan S,Yan-Sze I,Hogenkamp HP

更新日期：1992-12-01 00:00:00

abstract：:To study the mechanisms by which insulin regulates proliferation, we have compared wild-type Cloudman melanoma cells, whose growth in inhibited by insulin (insinh) to variant lines that were genetically selected for resistance to insulin (insres). Scatchard analysis of insulin binding to five insres) lines and six ins...

journal_title：Melanoma research

authors： Slominski A,McNeely T,Pawelek J

更新日期：1992-07-01 00:00:00

abstract：:Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The extracts producing singlet oxygen were then evaluated for cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines using the 3-[4,5-dimeth...

journal_title：Melanoma research

authors： Aydoğmuş-Öztürk F,Günaydin K,Öztürk M,Jahan H,Duru ME,Choudhary MI

更新日期：2018-12-01 00:00:00

abstract：:The aim of our study was to evaluate the clinical and morphological features of primary malignant melanomas of the urinary bladder. We obtained information on five such cases from three different institutions. These were three men and two women between 52 and 76 years of age. Three tumors presented with hematuria, one...

journal_title：Melanoma research

authors： Karabulut YY,Erdogan S,Sayar H,Ergen A,Ertoy Baydar D

更新日期：2016-12-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatmen...

journal_title：Melanoma research

authors： Cahill RA,McGreal G,Neary P,Redmond HP

更新日期：2001-10-01 00:00:00

abstract：:Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We ...

journal_title：Melanoma research

authors： Caini S,Gandini S,Botta F,Tagliabue E,Raimondi S,Nagore E,Zanna I,Maisonneuve P,Newton-Bishop J,Polsky D,Lazovich D,Kumar R,Kanetsky PA,Hoiom V,Ghiorzo P,Landi MT,Ribas G,Menin C,Stratigos AJ,Palmieri G,Guida G,

更新日期：2020-10-01 00:00:00

abstract：:In this study we evaluated the overexpression status of HER-2 and its prognostic significance on survival in patients with thick cutaneous malignant melanoma. The immuno-alkaline phosphatase antigen detection technique was applied to archival diagnostic material from 51 patients with primary lesions measuring >or= 10 ...

journal_title：Melanoma research

authors： Eliopoulos P,Mohammed MQ,Henry K,Retsas S

更新日期：2002-04-01 00:00:00