Enhanced effects of multiple treatment electrochemotherapy.

abstract：:In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed a...

journal_title：Melanoma research

authors： Wu C,Li X,Tian M

更新日期：2005-06-01 00:00:00

abstract：:Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...

journal_title：Melanoma research

authors： Ijland SA,Jager MJ,Heijdra BM,Westphal JR,Peek R

更新日期：1999-10-01 00:00:00

abstract：:This study examines whether 6-thioguanine resistant T cells (mutant) from metastatic melanoma patients are enriched for melanoma-associated T cells compared to T cells obtained analogously without thioguanine selection (wild-type). Melanoma-associated antigen pentamer staining was performed on 5 tumour and 9 periphera...

journal_title：Melanoma research

authors： Zuleger CL,Newton MA,Ma X,Ong IM,Pei Q,Albertini MR

更新日期：2020-02-01 00:00:00

abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...

journal_title：Melanoma research

authors： Guenova E,Lichte V,Hoetzenecker W,Woelbing F,Moehrle M,Roecken M,Schaller M

更新日期：2009-08-01 00:00:00

abstract：:Levels of eumelanin (EM) and pheomelanin (PM) of uveal melanoma cells have not been measured and compared with those of normal uveal melanocytes. EM and PM amounts in four immortal human uveal melanoma cell lines were measured by chemical degradation and microanalytical high-performance liquid chromatography and compa...

journal_title：Melanoma research

authors： Hu DN,Wakamatsu K,Ito S,McCormick SA

更新日期：2009-04-01 00:00:00

abstract：:Primary malignant melanoma of the esophagus is an extremely rare, but highly aggressive, tumor. The prognosis for primary malignant melanoma of the esophagus remains dismal in most literatures. We report here a case of primary malignant melanoma of the esophagus that was treated by surgical resection and, additionally...

journal_title：Melanoma research

authors： Yang X,Qu J,Wang S

更新日期：2010-02-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Melan-A is widely used in the diagnostics of human melanoma. The immunogenicity of this glycoprotein makes it a potential target in immunotherapy and several authors have suggested its potential as a prognostic factor. Up to now there has been no clear direct evidence of changes of Melan-A expression during the progre...

journal_title：Melanoma research

authors： Sztramska A,Dymerska D,Chwirot BW

更新日期：2008-08-01 00:00:00

abstract：:Preoperative assessment of melanoma invasion by sonometry has been reported to exhibit a high correlation with postoperative histometry based on the determination of a regression coefficient. We believe that this approach is not adequate and that it can be misleading. We therefore applied an appropriate statistical ap...

journal_title：Melanoma research

authors： Partsch B,Binder M,Püspök-Schwarz M,Wolff K,Pehamberger H

更新日期：1996-10-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...

journal_title：Melanoma research

authors： Garbe C,Hauschild A,Volkenandt M,Schadendorf D,Stolz W,Reinhold U,Kortmann RD,Kettelhack C,Frerich B,Keilholz U,Dummer R,Sebastian G,Tilgen W,Schuler G,Mackensen A,Kaufmann R

更新日期：2008-02-01 00:00:00

abstract：:Little population-based data has been published about skin cancers in children and young adults. In this study, 200 cases of melanoma and non-melanoma skin cancers diagnosed under 25 years of age in the North of England from 1968-1995 were obtained from the Northern Region Young Persons' Malignant Disease Registry. Th...

journal_title：Melanoma research

authors： Pearce MS,Parker L,Cotterill SJ,Gordon PM,Craft AW

更新日期：2003-08-01 00:00:00

abstract：:Melanoma tumors have been shown to comprise both invasive and proliferative cell subpopulations. These populations are highly plastic, thus hampering full characterization and therapeutic targeting of dormant and partially dedifferentiated invasive cells. We have reported, previously, that melanoma cells grown in a se...

journal_title：Melanoma research

authors： Ghislin S,Deshayes F,Lauriol J,Middendorp S,Martins I,Al-Daccak R,Alcaide-Loridan C

更新日期：2012-06-01 00:00:00

abstract：:The p53 pathway regulates stress response, and variations in p53, MDM2, and MDM4 may predispose an individual to tumor development. The aim of this study was to study the impact of genetic variation on sporadic and hereditary melanoma. We have analyzed a combination of three functionally relevant variants of the p53 p...

journal_title：Melanoma research

authors： Thunell LK,Bivik C,Wäster P,Fredrikson M,Stjernström A,Synnerstad I,Rosdahl I,Enerbäck C

更新日期：2014-06-01 00:00:00

abstract：:Resistance to various antineoplastic agents is common in the clinical management of malignant melanoma. The biological mechanisms conferring these different drug-resistant phenotypes are still unclear. To identify potential factors mediating drug resistance to melanoma cells, the mRNA expression profiles of the parent...

journal_title：Melanoma research

authors： Györffy B,Serra V,Materna V,Schäfer R,Dietel M,Schadendorf D,Lage H

更新日期：2006-04-01 00:00:00

abstract：:The incidence of melanoma has increased continuously during the last decade. Surgery is the mainstay of therapy but, for patients with thick lesions or regional metastatic lymph nodes, there is a high risk of relapse. For this group of patients, there is no standard therapy or general agreement amongst oncologists. In...

journal_title：Melanoma research

authors： Queirolo P,Acquati M,Kirkwood JM,Eggermont AM,Rocca A,Testori A

更新日期：2005-10-01 00:00:00

abstract：:In metastatic melanoma (MM) immunomodulating agents, such as interleukin-2 (IL-2) and interferon-α (IFN-α), have shown therapeutic benefit as they enhance antitumor immune response. Considering tumor-induced suppression of natural killer (NK) cell activity, it is of interest to study the affect of these cytokines on t...

journal_title：Melanoma research

authors： Konjević G,Mirjačić Martinović K,Vuletić A,Babović N

更新日期：2010-12-01 00:00:00

abstract：:Melanoma cells are unusual because, unlike most epithelial tumours, constitutive expression of HLA class II antigens is common. We have previously demonstrated that a peptide-specific CD4+ T-cell clone proliferates briskly in response to peptide and HLA class II expressing melanoma cell lines derived from metastases. ...

journal_title：Melanoma research

authors： Brady MS,Eckels DD,Lee F,Ree SY,Lee JS

更新日期：1999-04-01 00:00:00

abstract：:The nm23 gene is a putative tumour and metastasis suppressor gene. A number of studies have found that reduction of its expression is associated with increased metastatic potential in several human malignancies. Similarly, clinical studies have shown correlation between reduced nm23 protein expression and a poor progn...

journal_title：Melanoma research

authors： Sarris M,Scolyer RA,Konopka M,Thompson JF,Harper CG,Lee CS

更新日期：2004-02-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:Selective BRAF inhibitors (BRAFi) yield objective responses in 50% of patients with metastatic BRAF V600E mutant melanoma. Adding an MEK inhibitor increases this response rate to 70%. Limited data are available on the outcomes of unresectable stage III patients, and it remains unclear whether BRAF-targeted therapy can...

journal_title：Melanoma research

authors： Sloot S,Zager JS,Kudchadkar RR,Messina JL,Benedict JJ,Gonzalez RJ,DeConti R,Turner LM,McCardle T,Smalley KS,Weber JS,Sondak VK,Gibney GT

更新日期：2016-02-01 00:00:00

abstract：:Melanomas are promising targets for immunotherapy, as they express a number of tissue-specific antigens against which immune responses can be elicited. We have previously described transgenic mice in which malignant cutaneous melanomas are produced. The 1042 melanoma cell line, derived from a primary melanoma in one o...

journal_title：Melanoma research

authors： Milling SW,Sai T,Silvers WK,Mintz B

更新日期：2004-12-01 00:00:00

abstract：:The aim was to evaluate toxicity and oncological outcome of combined stereotactic radiosurgery (SRS) and immunotherapy or targeted therapy in patients with multiple brain metastases originating from malignant melanoma. Despite the fact that both SRS and kinase inhibitors or immune checkpoint inhibitors are considered ...

journal_title：Melanoma research

authors： Stera S,Balermpas P,Blanck O,Wolff R,Wurster S,Baumann R,Szücs M,Loutfi-Krauss B,Wilhelm ML,Seifert V,Rades D,Rödel C,Dunst J,Hildebrandt G,Arnold A,Meissner M,Kähler KC

更新日期：2019-04-01 00:00:00

abstract：:Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based databa...

journal_title：Melanoma research

authors： Singh P,Kim HJ,Schwartz RA

更新日期：2016-08-01 00:00:00

abstract：:We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985. Computer linkage with a population-b...

journal_title：Melanoma research

authors： Rossing MA,Daling JR,Weiss NS,Moore DE,Self SG

更新日期：1995-04-01 00:00:00

abstract：:Melanocytes are pigmented cells derived from the neural crest; their proliferation is restrained by immune system. The eruption of nevi after an immunosuppressive condition is a peculiar phenomenon indicating that the immune system may play a major role in limiting proliferation of melanocytes. In this review, we anal...

journal_title：Melanoma research

authors： Zattra E,Fortina AB,Bordignon M,Piaserico S,Alaibac M

更新日期：2009-04-01 00:00:00

abstract：:Sideritis leptoclada O. Schwarz et P.H. Davis extracts were evaluated for its singlet oxygen production capacity using spectrophotometric method. The extracts producing singlet oxygen were then evaluated for cytotoxicity against malignant melanoma cancer (HT-144) and fibroblast (3T3) cell lines using the 3-[4,5-dimeth...

journal_title：Melanoma research

authors： Aydoğmuş-Öztürk F,Günaydin K,Öztürk M,Jahan H,Duru ME,Choudhary MI

更新日期：2018-12-01 00:00:00

abstract：:The retinoblastoma protein (pRb) pathway is critical in regulating the G1 phase of the cell cycle and it is frequently disrupted in human cancers. Components of the pRb pathway which are often altered in tumour progression include the INK4 cyclin-dependent kinase (CDK) inhibitors p16INK4a/ CDKN2A and p15INK4b/CDKN2B, ...

journal_title：Melanoma research

authors： Rizos H,Darmanian AP,Indsto JO,Shannon JA,Kefford RF,Mann GJ

更新日期：1999-02-01 00:00:00

abstract：:Cell free extracts from metastases of human melanoma contain a highly active ribonucleoside diphosphate reductase (RR) which uses guanosine diphosphate (GDP) as substrate and deoxythymidine triphosphate (dTTP) as effector. No activity could be detected in these extracts when cytidine diphosphate (CDP) was used as the ...

journal_title：Melanoma research

authors： Schallreuter KU,Elgren TE,Nelson LS Jr,MacFarlan S,Yan-Sze I,Hogenkamp HP

更新日期：1992-12-01 00:00:00