Inhibition of melanoma growth after treatment with dendritic cells in a Tyr-SV40E murine model requires CD4+ T cells but not CD8+ T cells.

abstract：:Resistance to various antineoplastic agents is common in the clinical management of malignant melanoma. The biological mechanisms conferring these different drug-resistant phenotypes are still unclear. To identify potential factors mediating drug resistance to melanoma cells, the mRNA expression profiles of the parent...

journal_title：Melanoma research

authors： Györffy B,Serra V,Materna V,Schäfer R,Dietel M,Schadendorf D,Lage H

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Melanoma is the leading cause of death from skin cancers and its etiology is complex. Recent discoveries related to genetic risk factors are helping us to understand melanoma pathogenesis better. Nuclear factor-κB (NF-κB) has a critical role in immunity, inflammation, and tumor growth. The 94ins/del ATTG (rs...

journal_title：Melanoma research

authors： Escobar GF,Arraes JA,Bakos L,Ashton-Prolla P,Giugliani R,Callegari-Jacques SM,Santos S,Bakos RM

更新日期：2016-08-01 00:00:00

abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

journal_title：Melanoma research

authors： Yin G,Guo W,Chen X,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:The transcription factor CUTL1 (CCAAT displacement protein 1) has been reported to participate in the proliferation of diverse types of cancer. In the present study, we investigated the potential involvement of CUTL1 in the proliferation of malignant melanoma. We found that CUTL1 expression was upregulated in malignan...

journal_title：Melanoma research

authors： Fan X,Wang H,Zhou J,Wang S,Zhang X,Li T,Nie Y,Liu B

更新日期：2014-06-01 00:00:00

abstract：:Intercellular adhesion molecule (ICAM)-1 and mucin isotype MUC18 were originally identified as melanoma progression antigens by monoclonal antibodies (MAb) generated in a search for molecules expressed by melanomas but not detectable on benign naevi. As MAb detect single epitopes whose accessibility may be modulated, ...

journal_title：Melanoma research

authors： Kraus A,Masat L,Johnson JP

更新日期：1997-08-01 00:00:00

abstract：:Conjunctival melanoma is a rare disease, and little is known about its molecular background. Here, we present the case of a 48-year-old patient with conjunctival melanoma and metachronic lymph node and skin metastasis with KRAS p.K117Y mutation in exon 4 in all the lesions. The cancer genome interpreter predicted this...

journal_title：Melanoma research

authors： Del Carpio Huerta LP,Mas Castells M,Anguera Palacios G,Sullivan I,Gonzalez Vidal A,Majem Tarruella M

更新日期：2018-04-01 00:00:00

abstract：:The concept of 'vasculogenic mimicry' (VM) was introduced to describe the unique ability of highly invasive tumor cells to form capillary-like structures (CLS) and matrix-rich patterned network in three-dimensional culture that mimic embryonic vasculogenic network. Recently, we have shown that CLS formation requires a...

journal_title：Melanoma research

authors： Vartanian AA,Burova OS,Stepanova EV,Baryshnikov AY,Lichinitser MR

更新日期：2007-12-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:Single-agent anti-PD1 antibodies are usually very well tolerated, but serious toxicity can still occur. Despite the PD-1 pathway seems to be relevant in the pathogenesis of immune-related myositis, anti-PD1-related myositis is generally a rare side effect of the treatment and usually not serious. However, its frequenc...

journal_title：Melanoma research

authors： Liu WK,Naban N,Kaul A,Patel N,Fusi A

更新日期：2021-02-01 00:00:00

abstract：:An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longi...

journal_title：Melanoma research

authors： Olsen CM,Lane SW,Green AC

更新日期：2016-04-01 00:00:00

abstract：:When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated and injected into subjects, long-term antitumour immunity is induced. Optimally, existing melanomas induced to produce cytokines in vivo could stimulate this same immune response. Although in vivo electroporation enha...

journal_title：Melanoma research

authors： Heller L,Pottinger C,Jaroszeski MJ,Gilbert R,Heller R

更新日期：2000-12-01 00:00:00

abstract：:We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

journal_title：Melanoma research

authors： Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

更新日期：2004-12-01 00:00:00

abstract：:Microsatellite instability (MSI) is caused by replication errors due to deficient DNA mismatch repair and has been associated with tumour progression in various types of cancer. Controversial results have been reported concerning the frequency and significance of MSI in malignant melanoma. In this study, the time of o...

journal_title：Melanoma research

authors： Palmieri G,Ascierto PA,Cossu A,Colombino M,Casula M,Botti G,Lissia A,Tanda F,Castello G

更新日期：2003-04-01 00:00:00

abstract：:Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...

journal_title：Melanoma research

authors： Ijland SA,Jager MJ,Heijdra BM,Westphal JR,Peek R

更新日期：1999-10-01 00:00:00

abstract：:Genes in the S100 family are abnormally expressed in a variety of tumor cells and are associated with clinical pathology, but their prognostic value in melanoma patients has not yet been fully elucidated. In this study, we extracted and profiled S100 family mRNA expression data and corresponding clinical data from the...

journal_title：Melanoma research

authors： Xiong TF,Pan FQ,Li D

更新日期：2019-02-01 00:00:00

abstract：:The nm23 gene is a putative tumour and metastasis suppressor gene. A number of studies have found that reduction of its expression is associated with increased metastatic potential in several human malignancies. Similarly, clinical studies have shown correlation between reduced nm23 protein expression and a poor progn...

journal_title：Melanoma research

authors： Sarris M,Scolyer RA,Konopka M,Thompson JF,Harper CG,Lee CS

更新日期：2004-02-01 00:00:00

abstract：:Two human melanoma tumour cell lines, one radiation resistant and one radiation sensitive, were studied for their capacity for repair of sublethal radiation damage (SLDR) and for hyperthermia inhibition of radiation damage. The most resistant cell line demonstrated a survival curve with a large shoulder and a large SL...

journal_title：Melanoma research

authors： Raaphorst GP,Mao JP,Ng CE

更新日期：1994-06-01 00:00:00

abstract：:The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...

journal_title：Melanoma research

authors： Garbe C,Hauschild A,Volkenandt M,Schadendorf D,Stolz W,Reinhold U,Kortmann RD,Kettelhack C,Frerich B,Keilholz U,Dummer R,Sebastian G,Tilgen W,Schuler G,Mackensen A,Kaufmann R

更新日期：2008-02-01 00:00:00

abstract：:Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...

journal_title：Melanoma research

authors： Guenova E,Lichte V,Hoetzenecker W,Woelbing F,Moehrle M,Roecken M,Schaller M

更新日期：2009-08-01 00:00:00

abstract：:In human melanoma no complete information about the expression of the apoptosis-promoting and apoptosis-inhibiting members of the Bcl-2 family has been available to date. In this study we have investigated by Western blotting the expression pattern of Bcl-2 and its homologues Bax, Bak, Bcl-xL, Bcl-xS, Mcl-1 and Bad in...

journal_title：Melanoma research

authors： Selzer E,Schlagbauer-Wadl H,Okamoto I,Pehamberger H,Pötter R,Jansen B

更新日期：1998-06-01 00:00:00

abstract：:Between 6 and 14% of malignant melanomas have been reported to occur in a familial pattern. In this study 785 melanoma patients from the Victorian Melanoma Service and the private practice of a dermatologist were assessed for the total number of melanocytic naevi, the number of dysplastic naevi and other clinical char...

journal_title：Melanoma research

authors： Ang CG,Kelly JW,Fritschi L,Dowling JP

更新日期：1998-10-01 00:00:00

abstract：:Several hypotheses have explicitly implicated the role of an altered redox status of melanin in the aetiology of melanoma and macular degeneration. The balance between the intrinsic anti-oxidant and pro-oxidant properties of melanin is lost, resulting in an altered redox phenotype. We propose that such an alteration o...

journal_title：Melanoma research

authors： Sarangarajan R,Apte SP

更新日期：2006-02-01 00:00:00

abstract：:A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...

journal_title：Melanoma research

authors： Salgado C,Kwesi-Maliepaard EM,Jochemsen AG,Visser M,Harland M,van Leeuwen F,van Doorn R,Gruis N

更新日期：2019-12-01 00:00:00

abstract：:Regional lymph nodes are affected frequently by melanoma metastasis. Its microenvironment may be associated with tumor progression. We investigated sentinel nodes with and without tumor and negative nodes surrounding positive nodes, looking for patterns related to tumor immune interaction and lymphovascular progressio...

journal_title：Melanoma research

authors： Alessi C,Scapulatempo Neto C,Viana CR,Vazquez VL

更新日期：2017-12-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:The objective of this study is to assess the expression of heat shock protein 105 (HSP105) in melanoma and benign melanocytic lesions. The expression of HSP105 in 62 human melanoma samples--46 primary and 16 metastatic lesions--and 42 melanocytic naevi samples, was assessed by immunohistochemistry. Western blotting wa...

journal_title：Melanoma research

authors： Muchemwa FC,Nakatsura T,Fukushima S,Nishimura Y,Kageshita T,Ihn H

更新日期：2008-06-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...

journal_title：Melanoma research

authors： Berrocal A,Arance A,Lopez Martin JA,Soriano V,Muñoz E,Alonso L,Espinosa E,Lopez Criado P,Valdivia J,Martin Algarra S,Spanish Melanoma Group.

更新日期：2014-12-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Ninety primary melanoma patients were studied to investigate the importance of adopting the simultaneous use of patent blue dye (PBD) and lymphoscintigraphy plus gamma detection probe to locate the sentinel node (SN). In total 135 SNs in 105 basins were visualized preoperatively under a gamma camera after lymphoscinti...

journal_title：Melanoma research

authors： Testori A,Bartolomei M,Grana C,Mezzetti M,Chinol M,Mazzarol G,Lazzari I,Paganelli G,Geraghty JG,Andreoni B,Veronesi U

更新日期：1999-12-01 00:00:00