The influence of postoperative lymph node radiation therapy on overall survival of patients with stage III melanoma, a National Cancer Database analysis.

abstract：:Melanoma is one of the most common cancers worldwide and its incidence has been increasing over the past few decades. Gallic acid (GA) can inhibit the growth of human cancer cells in vitro and in vivo. However, there is no available information to address the effects of GA on migration and invasion of human skin cance...

journal_title：Melanoma research

authors： Lo C,Lai TY,Yang JS,Yang JH,Ma YS,Weng SW,Lin HY,Chen HY,Lin JG,Chung JG

更新日期：2011-08-01 00:00:00

abstract：:The aim of our study was to evaluate the clinical and morphological features of primary malignant melanomas of the urinary bladder. We obtained information on five such cases from three different institutions. These were three men and two women between 52 and 76 years of age. Three tumors presented with hematuria, one...

journal_title：Melanoma research

authors： Karabulut YY,Erdogan S,Sayar H,Ergen A,Ertoy Baydar D

更新日期：2016-12-01 00:00:00

abstract：:Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melan...

journal_title：Melanoma research

authors： Khurana S,Baldeo C,Joseph RW

更新日期：2019-06-01 00:00:00

abstract：:Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which are applied directly to the tumour. The pulses facilitate delivery of drug through the plasma membrane. Enhanced delivery is rest...

journal_title：Melanoma research

authors： Jaroszeski MJ,Gilbert R,Perrott R,Heller R

更新日期：1996-12-01 00:00:00

abstract：:This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BC...

journal_title：Melanoma research

authors： Chiarion Sileni V,Nortilli R,Aversa SM,Paccagnella A,Medici M,Corti L,Favaretto AG,Cetto GL,Monfardini S

更新日期：2001-04-01 00:00:00

abstract：:Accurate staging of patients with primary cutaneous melanoma includes assessment of regional lymph nodes for the presence of micrometastatic disease. Sentinel lymph node biopsy is highly accurate but is an invasive surgical procedure with a 5-10% complication rate, and requires labour-intensive and expensive histologi...

journal_title：Melanoma research

authors： Lean CL,Bourne R,Thompson JF,Scolyer RA,Stretch J,Li LX,Russell P,Mountford C

更新日期：2003-06-01 00:00:00

abstract：:For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...

journal_title：Melanoma research

authors： Danish H,Ferris MJ,Balagamwala E,Switchenko JM,Patel KR,Choudhary M,Craven C,Mendoza P,Suh J,Bergstrom C,Grossniklaus HE,M Aaberg T Sr,Singh A,Crocker IR,Khan MK

更新日期：2018-04-01 00:00:00

abstract：:Little population-based data has been published about skin cancers in children and young adults. In this study, 200 cases of melanoma and non-melanoma skin cancers diagnosed under 25 years of age in the North of England from 1968-1995 were obtained from the Northern Region Young Persons' Malignant Disease Registry. Th...

journal_title：Melanoma research

authors： Pearce MS,Parker L,Cotterill SJ,Gordon PM,Craft AW

更新日期：2003-08-01 00:00:00

abstract：:Pelvic sentinel lymph nodes (SLNs) are commonly identified during inguinal SLN biopsy for melanoma, but retrieval is not uniform among surgeons/centers. Few studies have assessed rates of micrometastases in pelvic versus superficial inguinal SLNs. Previous studies suggested that presence of pelvic SLNs was predicted b...

journal_title：Melanoma research

authors： Swords DS,Andtbacka RHI,Bowles TL,Hyngstrom JR

更新日期：2019-02-01 00:00:00

abstract：:The occurrence of cancer in pregnant women is not a common phenomenon and the real incidence of malignant melanoma during this period is unknown. Many authors reported a poor prognosis in pregnant women with melanoma compared with non-pregnant women's tumour. Several retrospective reviews reported a worsened prognosis...

journal_title：Melanoma research

authors： Silipo V,De Simone P,Mariani G,Buccini P,Ferrari A,Catricala C

更新日期：2006-12-01 00:00:00

abstract：:When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated and injected into subjects, long-term antitumour immunity is induced. Optimally, existing melanomas induced to produce cytokines in vivo could stimulate this same immune response. Although in vivo electroporation enha...

journal_title：Melanoma research

authors： Heller L,Pottinger C,Jaroszeski MJ,Gilbert R,Heller R

更新日期：2000-12-01 00:00:00

abstract：:The CXCR4 chemokine receptor plays an essential role in the homing of cells to organs expressing its ligand, CXCL12. CXCR4 expressed on tumor cells might regulate their traffic during metastasis. Here, we investigated whether the activation of CXCR4 on B16 murine melanoma cells regulates biological functions associate...

journal_title：Melanoma research

authors： Mendt M,Cardier JE

更新日期：2017-08-01 00:00:00

abstract：:The objective of this study was to describe the risk factor profile of skin cancer screening participants and to determine whether there is an association between the number of skin cancer/melanoma risk factors and the likelihood of diagnosis of a malignant melanoma. Seventy skin cancer screening clinics were held by ...

journal_title：Melanoma research

authors： Williams HA,Fritschi L,Beauchamp C,Katris P

更新日期：2006-08-01 00:00:00

abstract：:Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unkno...

journal_title：Melanoma research

authors： Kalialis LV,Drzewiecki KT,Klyver H

更新日期：2009-10-01 00:00:00

abstract：:The proto-oncogene c-Kit encodes a membrane receptor protein with intrinsic tyrosine kinase activity. Activation of c-Kit induces cell proliferation, differentiation or migration among different cell types. The present study provides evidence that c-Kit plays an important role in the cell differentiation rather than i...

journal_title：Melanoma research

authors： Luo D,Chen H,Searles G,Jimbow K

更新日期：1995-10-01 00:00:00

abstract：:Malignant melanoma is not only one of the most aggressive and lethal types of neoplasm, but its incidence in the general population is currently increasing at an alarming pace. It is interesting that most melanomas retain many of their characteristics of differentiation, including a dendritic nature and the production...

journal_title：Melanoma research

authors： Tsukamoto K,Gersten DM,Law LW,Hearing VJ

更新日期：1991-11-01 00:00:00

abstract：:Melan-A is widely used in the diagnostics of human melanoma. The immunogenicity of this glycoprotein makes it a potential target in immunotherapy and several authors have suggested its potential as a prognostic factor. Up to now there has been no clear direct evidence of changes of Melan-A expression during the progre...

journal_title：Melanoma research

authors： Sztramska A,Dymerska D,Chwirot BW

更新日期：2008-08-01 00:00:00

abstract：:The EORTC Melanoma Cooperative Group conducted a phase II trial (study number 18891) to study the effect of Toremifene in 45 patients with advanced, metastatic melanoma. Male and female patients, median age 61 (range 23-88) years received a mean total dose of 11 g (4.3-62.6) orally for at least 6 weeks. No objective r...

journal_title：Melanoma research

authors： Kleeberg UR,Engel E,Bröcker EB,Avril F,Israels P,Weiss J,Kangas L,van Glabbeke M,Lentz MA

更新日期：1993-04-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:In a previous large randomized, open-label study, retrospective subset analysis revealed that the addition of the Bcl-2 antisense oligonucleotide oblimersen to dacarbazine (Dac) significantly improved overall survival, progression-free survival, and the response rate in chemotherapy-naive patients with advanced melano...

journal_title：Melanoma research

authors： Bedikian AY,Garbe C,Conry R,Lebbe C,Grob JJ,Genasense Melanoma Study Group.

更新日期：2014-06-01 00:00:00

abstract：:Recreational exposure to the sun may not explain fully current trends in melanoma incidence. The hypothesis was examined whether carcinogens in water play a role in the development of cutaneous melanoma. In a case-control study, 128 melanoma patients and 168 patients with other types of malignancy completed a detailed...

journal_title：Melanoma research

authors： Nelemans PJ,Rampen FH,Groenendal H,Kiemeney LA,Ruiter DJ,Verbeek AL

更新日期：1994-10-01 00:00:00

abstract：:Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...

journal_title：Melanoma research

authors： Danen EH,de Vries TJ,Morandini R,Ghanem GG,Ruiter DJ,van Muijen GN

更新日期：1996-04-01 00:00:00

abstract：:The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in the field of epithelial-mesenchymal transition (EMT). One of these zinc-finger molecules is the transcription factor Snail, which controls gastrulation and neural...

journal_title：Melanoma research

authors： Kuphal S,Palm HG,Poser I,Bosserhoff AK

更新日期：2005-08-01 00:00:00

abstract：:To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were...

journal_title：Melanoma research

authors： Bohelay G,Battistella M,Pagès C,de Margerie-Mellon C,Basset-Seguin N,Viguier M,Kerob D,Madjlessi N,Baccard M,Archimbaud A,Comte C,Mourah S,Porcher R,Bagot M,Janin A,De Kerviler E,Lebbé C

更新日期：2015-12-01 00:00:00

abstract：:Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

journal_title：Melanoma research

authors： O'Leary DP,Byrnes KG,Power DG,Redmond HP

更新日期：2015-02-01 00:00:00

abstract：:Although pelvic computed tomography (CT) scans are frequently performed as a part of routine surveillance, the evidence for or against the routine use of these scans in patients with primary melanoma in the head and neck is weak. We conducted a retrospective study to evaluate the value of pelvic CT scans as routine su...

journal_title：Melanoma research

authors： Alvarado GC,Papadopoulos NE,Hwu WJ,Bedikian AY,Homsi J,Myers JN,Bronstein Y,Bassett RL,Hwu P,Kim KB

更新日期：2011-04-01 00:00:00

abstract：:The objective of this study was to identify novel tumor-suppressor genes in melanoma, using an integrative genomic approach. Data from: (i) earlier reports of DNA loss and gain in malignant melanoma accompanied by comparative genomic hybridization high-definition array data of the entire human genome; (ii) microarray ...

journal_title：Melanoma research

authors： Mithani SK,Smith IM,Califano JA

更新日期：2011-08-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:CDKN2A is thought to be the main candidate gene for melanoma susceptibility. Deletion or mutations in the CDKN2A gene may produce an imbalance between functional p16 and cyclin D, causing abnormal cell growth. We here describe a novel mutation consisting of a 1 bp deletion at nucleotide position 201 (codon 67) (CACGGc...

journal_title：Melanoma research

authors： Grammatico P,Binni F,Eibenschutz L,De Bernardo C,Grammatico B,Rinaldi R,De Simone P,Catricalà C

更新日期：2001-10-01 00:00:00