Abstract:
:To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were reviewed retrospectively. Histopathological results of US-CNB samples were classified as melanoma, other malignancy, suspicious, inadequate, or benign. The diagnostic accuracy of US-CNB was assessed by comparison with two reference standards: histopathological examination of the radical lymph node dissection or, when this was not available, clinical and radiological follow-up. The data from 72 US-CNB were analyzed. Forty-four melanomas, 22 benign, three other malignancies, three inadequate samples, and no inconclusive specimens were diagnosed. Seventy-one US-CNB results were confirmed (98.6%). US-CNB achieved high sensitivity, specificity, and positive predictive value (respectively, 97.9, 100, and 100%). No adverse events were reported after the procedure. US-CNB provided a mean tissue volume of 16.7 mm per lymphadenopathy. US-CNB has diagnostic value similar to that of fine-needle aspiration cytology. It represents a reliable alternative method in melanoma lymph node metastasis to avoid surgery in patients who will not benefit from it. US-CNB provides relatively large samples of tissue suitable for comprehensive genomic analyses currently needed for research and personalized care of melanoma patients.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Bohelay G,Battistella M,Pagès C,de Margerie-Mellon C,Basset-Seguin N,Viguier M,Kerob D,Madjlessi N,Baccard M,Archimbaud A,Comte C,Mourah S,Porcher R,Bagot M,Janin A,De Kerviler E,Lebbé Cdoi
10.1097/CMR.0000000000000161subject
Has Abstractpub_date
2015-12-01 00:00:00pages
519-27issue
6eissn
0960-8931issn
1473-5636journal_volume
25pub_type
杂志文章abstract::The proto-oncogene c-Kit encodes a membrane receptor protein with intrinsic tyrosine kinase activity. Activation of c-Kit induces cell proliferation, differentiation or migration among different cell types. The present study provides evidence that c-Kit plays an important role in the cell differentiation rather than i...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199510000-00002
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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doi:
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000657
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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journal_title:Melanoma research
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
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