当前位置： SCI文献检索 > MELANOMA RESEARCH期刊下所有文献 > Does complete response to systemic therapy in patients with stage IV melanoma translate into long-term survival?

Does complete response to systemic therapy in patients with stage IV melanoma translate into long-term survival?

Abstract：

:The aim of this study was to determine the impact of complete response (CR) to systemic therapy on survival. We reviewed the cases of 647 chemo-naive patients with metastatic melanoma who were treated with cisplatin-vinblastine-dacarbazine or cisplatin-taxol-dacarbazine alone, or cisplatin-vinblastine-dacarbazine together with interferon α or interleukin-2 plus interferon α. After excluding patients with uveal melanoma and patients who had resection of metastases, 567 patients were eligible to participate in this analysis. An event chart is presented for the 51 patients with CR and for three random samples of patients without CR. We compared overall survival of responders versus nonresponders using response as a time-dependent covariate in a Cox proportional hazards model. In addition, we used the landmark method, choosing 6 months as the landmark. Logistic regression techniques were used to determine factors associated with CR to therapy. All P values were 2-tailed and considered significant at α less than 0.05. Analyses were conducted using SAS for Windows. In this analysis, CR was associated with patients who were younger, male, and who had better performance status, lower M-stage, no liver metastases, and no visceral sites involved, normal LDH and had received biochemotherapy. While accounting for these factors, the relationship between CR and survival remained statistically significant, suggesting a causal relationship between response and survival. Using 6-month landmark analysis method, we still find a significant difference in overall survival between response groups, favoring patients who achieved CR with systemic therapy. In conclusion, CR to systemic therapy is associated with long-term survival in patients with stage IV melanoma.

journal_name

Melanoma Res

journal_title

Melanoma research

authors

Bedikian AY,Johnson MM,Warneke CL,Papadopoulos NE,Kim KB,Hwu WJ,McIntyre S,Rohlfs M,Homsi J,Hwu P

doi

10.1097/CMR.0b013e328341445f

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

84-90

issue

1

eissn

0960-8931

issn

1473-5636

journal_volume

21

pub_type

杂志文章,评审

相关文献

MELANOMA RESEARCH文献大全
  • Immunohistochemical analysis of the S100A1, S100B, CD44 and Bcl-2 antigens and the rate of cell proliferation assessed by Ki-67 antibody in benign and malignant melanocytic tumours.

    abstract：:Malignant melanomas usually have an unfavourable prognosis and poor response to chemotherapy. Deregulation of cell proliferation, programmed cell death and intercellular interactions are among several important mechanisms that might lead to malignant transformation of melanocytes and melanoma progression. The S100A1, ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0b013e3283350554

    authors： Sviatoha V,Tani E,Kleina R,Sperga M,Skoog L

    更新日期：2010-04-01 00:00:00

  • Lovastatin-induced apoptosis in human melanoma cell lines.

    abstract：:The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell lines was examined by Cell T...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200504000-00001

    authors： Shellman YG,Ribble D,Miller L,Gendall J,Vanbuskirk K,Kelly D,Norris DA,Dellavalle RP

    更新日期：2005-04-01 00:00:00

  • MDM2 SNP309 promoter polymorphism confers risk for hereditary melanoma.

    abstract：:The p53 pathway regulates stress response, and variations in p53, MDM2, and MDM4 may predispose an individual to tumor development. The aim of this study was to study the impact of genetic variation on sporadic and hereditary melanoma. We have analyzed a combination of three functionally relevant variants of the p53 p...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000063

    authors： Thunell LK,Bivik C,Wäster P,Fredrikson M,Stjernström A,Synnerstad I,Rosdahl I,Enerbäck C

    更新日期：2014-06-01 00:00:00

  • Analysis of gene expression profiles in melanoma cells with acquired resistance against antineoplastic drugs.

    abstract：:Resistance to various antineoplastic agents is common in the clinical management of malignant melanoma. The biological mechanisms conferring these different drug-resistant phenotypes are still unclear. To identify potential factors mediating drug resistance to melanoma cells, the mRNA expression profiles of the parent...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/01.cmr.0000215037.23188.58

    authors： Györffy B,Serra V,Materna V,Schäfer R,Dietel M,Schadendorf D,Lage H

    更新日期：2006-04-01 00:00:00

  • Quantitative assessment of the association between XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of cutaneous melanoma.

    abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

    journal_title：Melanoma research

    pub_type： 杂志文章,meta分析

    doi：10.1097/CMR.0000000000000246

    authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

    更新日期：2016-06-01 00:00:00

  • Metformin: oxidative and proliferative parameters in-vitro and in-vivo models of murine melanoma.

    abstract：:Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on thi...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000391

    authors： de Souza Neto FP,Bernardes SS,Marinello PC,Melo GP,Luiz RC,Cecchini R,Cecchini AL

    更新日期：2017-12-01 00:00:00

  • Association between germ cell tumours, large numbers of naevi, atypical naevi and melanoma.

    abstract：:Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200104000-00005

    authors： Avril MF,Chompret A,Verne-Fourment L,Terrier-Lacombe MJ,Spatz A,Fizazi K,Bressac-de Paillerets B,Demenais F,Théodore C

    更新日期：2001-04-01 00:00:00

  • Response to targeted therapy in two patients with metastatic melanoma carrying rare BRAF exon 15 mutations: A598_T599insV and V600_K601delinsE.

    abstract：:Concurrent BRAF-MEK inhibition improves clinical outcomes in patients with advanced BRAF V600E/K-mutant melanoma. There is currently less evidence for the efficacy of this treatment in patients with rare BRAF non-V600E/K genotypes. We report on two patients with rare BRAF exon 15 mutations - BRAF A598_T599insV and V60...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000376

    authors： Rogiers A,Vander Borght S,Tuand K,Wolter P,Stas M,Boecxstaens V,Garmyn M,van den Oord JJ,Vandenberghe P,Bechter O

    更新日期：2017-10-01 00:00:00

  • PD-1/PD-L1 and VEGF-A/VEGF-C expression in lymph node microenvironment and association with melanoma metastasis and survival.

    abstract：:Regional lymph nodes are affected frequently by melanoma metastasis. Its microenvironment may be associated with tumor progression. We investigated sentinel nodes with and without tumor and negative nodes surrounding positive nodes, looking for patterns related to tumor immune interaction and lymphovascular progressio...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000396

    authors： Alessi C,Scapulatempo Neto C,Viana CR,Vazquez VL

    更新日期：2017-12-01 00:00:00

  • Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature.

    abstract：:We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...

    journal_title：Melanoma research

    pub_type： 杂志文章,评审

    doi：10.1097/CMR.0b013e32833faf6a

    authors： Valenzano Menada M,Moioli M,Garaventa A,Nozza P,Foppiano M,Trimarchi N,Fulcheri E

    更新日期：2010-12-01 00:00:00

  • No indication for performing sentinel node biopsy in melanoma patients with a Breslow thickness of less than 0.9 mm.

    abstract：:In thin melanomas, the involvement of regional nodes is very uncommon. Recent sentinel node (SN) studies have confirmed the absence of positive regional lymph nodes in melanomas < 0.76 mm and a 5% positivity in melanomas between 1.0 and 1.99 mm. The chance of regional lymph node involvement - and therefore whether it ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200106000-00013

    authors： Statius Muller MG,van Leeuwen PA,van Diest PJ,Vuylsteke RJ,Pijpers R,Meijer S

    更新日期：2001-06-01 00:00:00

  • Cyclic AMP-Epac signaling pathway contributes to repression of PUMA transcription in melanoma cells.

    abstract：:The universal second messenger cAMP regulates numerous cellular processes. Although the cAMP-signaling pathway leads to induction of gene transcription, it remains unknown whether this pathway contributes toward suppression of transcription. Here, we show that blockade of cAMP signaling using MDL12330A led to an incre...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000363

    authors： Lakhter AJ,Naidu SR

    更新日期：2017-10-01 00:00:00

  • Defining fast-growing melanomas: reappraisal of epidemiological, clinical, and histological features.

    abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0b013e328342f312

    authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

    更新日期：2011-04-01 00:00:00

  • Serum melatonin levels in melanoma patients after repeated oral administration.

    abstract：:The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma. Hourly blood samples were obtained from five patients for 24 h prior to melatonin administration and for 24 h during oral administration of melatonin, 50 mg every 4 h. ...

    journal_title：Melanoma research

    pub_type： 临床试验,杂志文章

    doi：10.1097/00008390-199402000-00009

    authors： Kane MA,Johnson A,Nash AE,Boose D,Mathai G,Balmer C,Yohn JJ,Robinson WA

    更新日期：1994-02-01 00:00:00

  • Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment.

    abstract：:Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0b013e3283531317

    authors： Sztiller-Sikorska M,Koprowska K,Jakubowska J,Zalesna I,Stasiak M,Duechler M,Czyz ME

    更新日期：2012-06-01 00:00:00

  • The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma.

    abstract：:We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200412000-00009

    authors： Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

    更新日期：2004-12-01 00:00:00

  • Mapping of occult melanoma micrometastases in the inguinal lymph node basin by immunohistochemistry and RT-PCR.

    abstract：:To examine the distribution of occult micrometastases that could be potential sources of recurrence, complete maps of microscopic and submicroscopic metastases in entire inguinal lymph node basins were generated in 13 melanoma patients who had undergone elective or therapeutic lymphadenectomy. Occult micrometastases w...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-199908000-00010

    authors： Hatta N,Fujimoto A,Takehara K,Takata M

    更新日期：1999-08-01 00:00:00

  • The influence of postoperative lymph node radiation therapy on overall survival of patients with stage III melanoma, a National Cancer Database analysis.

    abstract：:Recently, TROG 02.01 results showed that in stage III melanoma patients with nodal metastasis, adjuvant radiation to lymph node basin after nodal dissection improves lymph node field relapse without an overall survival (OS) benefit. However, this trial was neither designed nor powered to detect an OS difference. In th...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000292

    authors： Danish HH,Patel KR,Switchenko JM,Gillespie TW,Jhaveri J,Chowdhary M,Abugideiri M,Delman KA,Lawson DH,Khan MK

    更新日期：2016-12-01 00:00:00

  • Synchronous high-risk melanoma and lymphoid neoplasia.

    abstract：:Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatmen...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200110000-00012

    authors： Cahill RA,McGreal G,Neary P,Redmond HP

    更新日期：2001-10-01 00:00:00

  • Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells.

    abstract：:Ginsenoside Rg3 is an effective chemical component extracted from the red Panix. The experiment demonstrated that it might effectively inhibit proliferation and metastasis of tumor cells. The exact molecular mechanism of Rg3 remains unclear so far. To further explore the antitumor function of Rg3, we investigated the ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0b013e32830b3536

    authors： Chen J,Peng H,Ou-Yang X,He X

    更新日期：2008-10-01 00:00:00

  • Replacing surrogate measures by direct quantification of ultraviolet radiation exposure in registry-based analyses of seasonality of melanoma diagnoses.

    abstract：:Seasonal variation in melanoma diagnoses has been observed in numerous studies that used calendar time indicators. Depending on the latitude (and altitude) of the study region, the magnitude of seasonal and year-to-year variation of ultraviolet radiation (UVR) is neglected in these studies. An alternative approach com...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000205

    authors： Keller AK,Uter W,Pfahlberg AB,Radespiel-Tröger M,Mayer I,Gefeller O

    更新日期：2015-12-01 00:00:00

  • Linkage analysis in Dutch familial atypical multiple mole-melanoma (FAMMM) syndrome families. Effect of naevus count.

    abstract：:Familial atypical multiple mole-melanoma (FAMMM) syndrome is characterized by the familial occurrence of malignant melanoma of the skin in combination with multiple atypical precursor naevi. In the present study we performed linkage analysis in seven Dutch FAMMM families to define the relationship between the ultimate...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：

    authors： Gruis NA,Sandkuijl LA,Weber JL,van der Zee A,Borgstein AM,Bergman W,Frants RR

    更新日期：1993-08-01 00:00:00

  • 20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

    abstract：:The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000519

    authors： Bellocq D,Roy P,Kodjikian L,Mathis T,Nguyen AM,Herault J,Rivoire M,Négrier S,Thariat J,Grange JD

    更新日期：2020-06-01 00:00:00

  • Prognosis of endoscopic surgery and traditional open resection in mucosal melanoma of the nasal cavity and paranasal sinus.

    abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000516

    authors： Yin G,Guo W,Chen X,Huang Z

    更新日期：2019-02-01 00:00:00

  • Ipilimumab for advanced melanoma: experience from the Spanish Expanded Access Program.

    abstract：:Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000108

    authors： Berrocal A,Arance A,Lopez Martin JA,Soriano V,Muñoz E,Alonso L,Espinosa E,Lopez Criado P,Valdivia J,Martin Algarra S,Spanish Melanoma Group.

    更新日期：2014-12-01 00:00:00

  • Anti-programmed cell death-1 therapy in octogenarian and nonagenarian advanced/metastatic melanoma patients.

    abstract：:Immunotherapy with anti-programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Octogenarians and nonagenarians represent a significant cohort of melanoma patients. This multicenter retrospective analysis enrolled 499 patients treated with nivolumab or pembrolizumab. Seventy-three pati...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000705

    authors： Cybulska-Stopa B,Ziętek M,Kamińska-Winciorek G,Czarnecka AM,Piejko K,Galus Ł,Ziółkowska B,Kieszko S,Kempa-Kamińska N,Calik J,Zemełka T,Kubiatowski T,Suwiński R,Mackiewicz J,Rutkowski P

    更新日期：2021-02-01 00:00:00

  • Cytotoxic effects of violacein in human uveal melanoma cell lines.

    abstract：:Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/00008390-200410000-00014

    authors： Saraiva VS,Marshall JC,Cools-Lartigue J,Burnier MN Jr

    更新日期：2004-10-01 00:00:00

  • Nevi and Breslow thickness in melanoma: sex differences?

    abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000579

    authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

    更新日期：2020-04-01 00:00:00

  • Accuracy of sentinel lymph node dissection for melanoma staging in the presence of a collision tumour with a lymphoproliferative disease.

    abstract：:Sentinel lymph node dissection (SLND) identifies melanoma patients with metastatic disease who would benefit from radical lymph node dissection (RLND). Rarely, patients with melanoma have an underlying lymphoproliferative disease, and melanoma metastases might develop as collision tumours in the sentinel lymph node (S...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000098

    authors： Gero D,Queiros da Mota V,Boubaker A,Berthod G,de Leval L,Demartines N,Matter M

    更新日期：2014-08-01 00:00:00

  • A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma.

    abstract：:A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...

    journal_title：Melanoma research

    pub_type： 杂志文章

    doi：10.1097/CMR.0000000000000640

    authors： Salgado C,Kwesi-Maliepaard EM,Jochemsen AG,Visser M,Harland M,van Leeuwen F,van Doorn R,Gruis N

    更新日期：2019-12-01 00:00:00