No indication for performing sentinel node biopsy in melanoma patients with a Breslow thickness of less than 0.9 mm.

abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

journal_title：Melanoma research

authors： Yin G,Guo W,Chen X,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a...

journal_title：Melanoma research

authors： Schartz NE,Farges C,Madelaine I,Bruzzoni H,Calvo F,Hoos A,Lebbé C

更新日期：2010-06-01 00:00:00

abstract：:Conditional survival in patients with localized primary cutaneous malignant melanoma (CMM) is well described. However, conditional recurrence-free survival (RFS) has not been investigated before. The aim of this study was to determine conditional RFS and test for time dependency in prognostic factors in patients with ...

journal_title：Melanoma research

authors： Lyth J

更新日期：2018-12-01 00:00:00

abstract：:Microphthalmia transcription factor (Mitf) is involved in melanocyte development and differentiation. We previously reported that Mitf expression, as detected by immunohistochemical analysis, is an independent prognostic marker in patients with intermediate-thickness melanoma. However, the clinical significance of Mit...

journal_title：Melanoma research

authors： Naffouje S,Naffouje R,Bhagwandin S,Salti GI

更新日期：2015-12-01 00:00:00

abstract：:Despite the general advances in the chemotherapy of malignancies, progress comes slow in the management of patients with disseminated melanoma. Unreflected enthusiasm and frustrated scepticism are the scylla and charybdis between which the physician tries to choose the right way. ...

journal_title：Melanoma research

authors： Kleeberg UR

更新日期：1997-08-01 00:00:00

abstract：:Familial atypical multiple mole-melanoma (FAMMM) syndrome is characterized by the familial occurrence of malignant melanoma of the skin in combination with multiple atypical precursor naevi. In the present study we performed linkage analysis in seven Dutch FAMMM families to define the relationship between the ultimate...

journal_title：Melanoma research

authors： Gruis NA,Sandkuijl LA,Weber JL,van der Zee A,Borgstein AM,Bergman W,Frants RR

更新日期：1993-08-01 00:00:00

abstract：:A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...

journal_title：Melanoma research

authors： Salgado C,Kwesi-Maliepaard EM,Jochemsen AG,Visser M,Harland M,van Leeuwen F,van Doorn R,Gruis N

更新日期：2019-12-01 00:00:00

abstract：:Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...

journal_title：Melanoma research

authors： Ulmer A,Metzger S,Fierlbeck G

更新日期：2002-08-01 00:00:00

abstract：:Dermatologic toxicity is a known reaction of ipilimumab and vemurafenib. Because of the lack of effective treatments and aggressive nature of melanoma, treatments are often discontinued and new treatments are initiated in rapid succession. We report what we believe to be the first case of cumulative dermatologic toxic...

journal_title：Melanoma research

authors： Ludlow SP,Pasikhova Y

更新日期：2013-12-01 00:00:00

abstract：:Large population-based studies have shown a significant association between melanoma and lymphoid neoplasia, particularly non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL), that is independent of any treatment received for the initial tumour. This study examines the presentation, diagnosis, treatmen...

journal_title：Melanoma research

authors： Cahill RA,McGreal G,Neary P,Redmond HP

更新日期：2001-10-01 00:00:00

abstract：:Cutaneous malignant melanoma is one of the most common and aggressive forms of human cancers and has a poor prognosis. Activation of signal transducer and activator of transcription 3 (STAT3) has been found in several human cancers and is thought to correlate aggressive disease and poor response. In this study, we inv...

journal_title：Melanoma research

authors： Wu ZS,Cheng XW,Wang XN,Song NJ

更新日期：2011-12-01 00:00:00

abstract：:Interleukin-24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) is a unique cytokine-tumor suppressor that displays ubiquitous antitumor properties and tumor-specific killing activity. Oncostatin M (OSM) is the most active IL-6-type cytokine and inhibits the proliferation of various solid tumor cell lines. M...

journal_title：Melanoma research

authors： Xu Y,Zhang F,Qin L,Miao J,Sheng W,Xie Y,Xu X,Yang J,Qian H

更新日期：2014-02-01 00:00:00

abstract：:Although pelvic computed tomography (CT) scans are frequently performed as a part of routine surveillance, the evidence for or against the routine use of these scans in patients with primary melanoma in the head and neck is weak. We conducted a retrospective study to evaluate the value of pelvic CT scans as routine su...

journal_title：Melanoma research

authors： Alvarado GC,Papadopoulos NE,Hwu WJ,Bedikian AY,Homsi J,Myers JN,Bronstein Y,Bassett RL,Hwu P,Kim KB

更新日期：2011-04-01 00:00:00

abstract：:Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...

journal_title：Melanoma research

authors： Ijland SA,Jager MJ,Heijdra BM,Westphal JR,Peek R

更新日期：1999-10-01 00:00:00

abstract：:Malignant melanomas usually have an unfavourable prognosis and poor response to chemotherapy. Deregulation of cell proliferation, programmed cell death and intercellular interactions are among several important mechanisms that might lead to malignant transformation of melanocytes and melanoma progression. The S100A1, ...

journal_title：Melanoma research

authors： Sviatoha V,Tani E,Kleina R,Sperga M,Skoog L

更新日期：2010-04-01 00:00:00

abstract：:We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985. Computer linkage with a population-b...

journal_title：Melanoma research

authors： Rossing MA,Daling JR,Weiss NS,Moore DE,Self SG

更新日期：1995-04-01 00:00:00

abstract：:In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed a...

journal_title：Melanoma research

authors： Wu C,Li X,Tian M

更新日期：2005-06-01 00:00:00

abstract：:Appropriate margins of excision for melanoma have been well defined on the basis of prospective clinical trials. Various factors may result in a discrepancy between the intended clinical margin and the pathologic margin ex vivo, however, making it difficult to determine whether adequate excision margins have been obta...

journal_title：Melanoma research

authors： Clausen SP,Brady MS

更新日期：2005-12-01 00:00:00

abstract：:Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...

journal_title：Melanoma research

authors： Saraiva VS,Marshall JC,Cools-Lartigue J,Burnier MN Jr

更新日期：2004-10-01 00:00:00

abstract：:In several solid tumors, an increased stathmin expression is associated with both poor prognosis and resistance to certain chemotherapy types. However, the data regarding melanocytic lesions are very limited. The goals of our study are as follows: the assessment of stathmin expression in benign and malignant melanocyt...

journal_title：Melanoma research

authors： Dundr P,Simon K,Němejcová K,Bártů M,Tichá I,Michálková R,Jakša R,Věcková Z,Kodet O

更新日期：2019-04-01 00:00:00

abstract：:Pigmented basal cell carcinoma (PBCC) is a tumour with distinct clinical features which occasionally may be difficult to differentiate from malignant melanoma (MM). The purpose of this study was to re-examine the epiluminescence microscopy (ELM) criteria for PBCC and to determine their statistical significance in the ...

journal_title：Melanoma research

authors： Püspök-Schwarz M,Steiner A,Binder M,Partsch B,Wolff K,Pehamberger H

更新日期：1997-08-01 00:00:00

abstract：:Ninety primary melanoma patients were studied to investigate the importance of adopting the simultaneous use of patent blue dye (PBD) and lymphoscintigraphy plus gamma detection probe to locate the sentinel node (SN). In total 135 SNs in 105 basins were visualized preoperatively under a gamma camera after lymphoscinti...

journal_title：Melanoma research

authors： Testori A,Bartolomei M,Grana C,Mezzetti M,Chinol M,Mazzarol G,Lazzari I,Paganelli G,Geraghty JG,Andreoni B,Veronesi U

更新日期：1999-12-01 00:00:00

abstract：:Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agen...

journal_title：Melanoma research

authors： Heller R,Jaroszeski M,Perrott R,Messina J,Gilbert R

更新日期：1997-02-01 00:00:00

abstract：:Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...

journal_title：Melanoma research

authors： Sztiller-Sikorska M,Koprowska K,Jakubowska J,Zalesna I,Stasiak M,Duechler M,Czyz ME

更新日期：2012-06-01 00:00:00

abstract：:Melanoma tumors have been shown to comprise both invasive and proliferative cell subpopulations. These populations are highly plastic, thus hampering full characterization and therapeutic targeting of dormant and partially dedifferentiated invasive cells. We have reported, previously, that melanoma cells grown in a se...

journal_title：Melanoma research

authors： Ghislin S,Deshayes F,Lauriol J,Middendorp S,Martins I,Al-Daccak R,Alcaide-Loridan C

更新日期：2012-06-01 00:00:00

abstract：:Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

journal_title：Melanoma research

authors： O'Leary DP,Byrnes KG,Power DG,Redmond HP

更新日期：2015-02-01 00:00:00

abstract：:Primary malignant melanoma of the esophagus is an extremely rare, but highly aggressive, tumor. The prognosis for primary malignant melanoma of the esophagus remains dismal in most literatures. We report here a case of primary malignant melanoma of the esophagus that was treated by surgical resection and, additionally...

journal_title：Melanoma research

authors： Yang X,Qu J,Wang S

更新日期：2010-02-01 00:00:00

abstract：:Melanocytes are pigmented cells derived from the neural crest; their proliferation is restrained by immune system. The eruption of nevi after an immunosuppressive condition is a peculiar phenomenon indicating that the immune system may play a major role in limiting proliferation of melanocytes. In this review, we anal...

journal_title：Melanoma research

authors： Zattra E,Fortina AB,Bordignon M,Piaserico S,Alaibac M

更新日期：2009-04-01 00:00:00

abstract：:Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investi...

journal_title：Melanoma research

authors： Chen N,Gong J,Chen X,Xu M,Huang Y,Wang L,Geng N,Zhou Q

更新日期：2009-04-01 00:00:00

abstract：:In this study we compared the strength of the association of constitutional factors and sun exposure with cutaneous malignant melanoma (CMM) and basal cell carcinoma (BCC). We analysed 260 incident cases of CMM, 425 incident cases of BCC and two sets of population controls from previous case-control studies conducted ...

journal_title：Melanoma research

authors： Rosso S,Zanetti R,Pippione M,Sancho-Garnier H

更新日期：1998-12-01 00:00:00