The left ventricle as the first site of uveal melanoma metastasis 13 years after treatment of the primary tumor.


:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the left ventricle as the first site of uveal melanoma recurrence 13 years after treatment of his primary tumor. The metastatic tumor was considered unresectable. We describe the patient's medical management over the next 3 years, the course of his disease, and the results of our review of the literature.


Melanoma Res


Melanoma research


Kolandjian NA,Patel SP,Papadopoulos NE,Bedikian AY




Has Abstract


2011-04-01 00:00:00












  • Interleukin-6-induced Twist and N-cadherin enhance melanoma cell metastasis.

    abstract::Melanoma patients frequently have elevated serum levels of interleukin-6 (IL-6), which is correlated with a poor prognosis. IL-6 activates STAT3 phosphorylation, inducing the transcription of genes that regulate tumor cell proliferation and antiapoptosis. In addition, recent evidence suggests that IL-6 induces the epi...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Na YR,Lee JS,Lee SJ,Seok SH

    更新日期:2013-12-01 00:00:00

  • Cytoplasmic expression of nm23 predicts the potential for cerebral metastasis in patients with primary cutaneous melanoma.

    abstract::The nm23 gene is a putative tumour and metastasis suppressor gene. A number of studies have found that reduction of its expression is associated with increased metastatic potential in several human malignancies. Similarly, clinical studies have shown correlation between reduced nm23 protein expression and a poor progn...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Sarris M,Scolyer RA,Konopka M,Thompson JF,Harper CG,Lee CS

    更新日期:2004-02-01 00:00:00

  • Ultrasound-guided core needle biopsy of superficial lymph nodes: an alternative to fine-needle aspiration cytology for the diagnosis of lymph node metastasis in cutaneous melanoma.

    abstract::To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Bohelay G,Battistella M,Pagès C,de Margerie-Mellon C,Basset-Seguin N,Viguier M,Kerob D,Madjlessi N,Baccard M,Archimbaud A,Comte C,Mourah S,Porcher R,Bagot M,Janin A,De Kerviler E,Lebbé C

    更新日期:2015-12-01 00:00:00

  • Mapping of occult melanoma micrometastases in the inguinal lymph node basin by immunohistochemistry and RT-PCR.

    abstract::To examine the distribution of occult micrometastases that could be potential sources of recurrence, complete maps of microscopic and submicroscopic metastases in entire inguinal lymph node basins were generated in 13 melanoma patients who had undergone elective or therapeutic lymphadenectomy. Occult micrometastases w...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Hatta N,Fujimoto A,Takehara K,Takata M

    更新日期:1999-08-01 00:00:00

  • Successful palliation of stenosing anorectal melanoma by intratumoral injections with natural interferon-beta.

    abstract::Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Ulmer A,Metzger S,Fierlbeck G

    更新日期:2002-08-01 00:00:00

  • Risk of cutaneous melanoma in a cohort of infertile women.

    abstract::We assessed the risk of cutaneous malignant melanoma associated with the presence of ovulatory abnormalities and with the use of ovulation-inducing agents (such as clomiphene citrate) in a cohort of 3,837 women evaluated at infertility clinics in Seattle, WA, between 1974 and 1985. Computer linkage with a population-b...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Rossing MA,Daling JR,Weiss NS,Moore DE,Self SG

    更新日期:1995-04-01 00:00:00

  • Accuracy of sentinel lymph node dissection for melanoma staging in the presence of a collision tumour with a lymphoproliferative disease.

    abstract::Sentinel lymph node dissection (SLND) identifies melanoma patients with metastatic disease who would benefit from radical lymph node dissection (RLND). Rarely, patients with melanoma have an underlying lymphoproliferative disease, and melanoma metastases might develop as collision tumours in the sentinel lymph node (S...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Gero D,Queiros da Mota V,Boubaker A,Berthod G,de Leval L,Demartines N,Matter M

    更新日期:2014-08-01 00:00:00

  • Redox regulation of Brn-2/N-Oct-3 POU domain DNA binding activity and proteolytic formation of N-Oct-5 during melanoma cell nuclear extraction.

    abstract::Reversible oxidation sensitivity of N-Oct-3 DNA binding activity was seen when melanoma extracts and recombinant Brn-2 protein were treated with a variety of metals, hydrogen peroxide and the cysteine disulphide bond forming agent diamide. Western blot analysis of diamide-oxidized N-Oct-3 protein indicated that this w...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Smith AG,Brightwell G,Smit SE,Parsons PG,Sturm RA

    更新日期:1998-02-01 00:00:00

  • Serum zinc levels are increased in melanoma patients.

    abstract::We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Ros-Bullón MR,Sánchez-Pedreño P,Martínez-Liarte JH

    更新日期:1998-06-01 00:00:00

  • Immunohistochemical analysis of the S100A1, S100B, CD44 and Bcl-2 antigens and the rate of cell proliferation assessed by Ki-67 antibody in benign and malignant melanocytic tumours.

    abstract::Malignant melanomas usually have an unfavourable prognosis and poor response to chemotherapy. Deregulation of cell proliferation, programmed cell death and intercellular interactions are among several important mechanisms that might lead to malignant transformation of melanocytes and melanoma progression. The S100A1, ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Sviatoha V,Tani E,Kleina R,Sperga M,Skoog L

    更新日期:2010-04-01 00:00:00

  • Snail-regulated genes in malignant melanoma.

    abstract::The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in the field of epithelial-mesenchymal transition (EMT). One of these zinc-finger molecules is the transcription factor Snail, which controls gastrulation and neural...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Kuphal S,Palm HG,Poser I,Bosserhoff AK

    更新日期:2005-08-01 00:00:00

  • The effect of temozolomide-based chemotherapy in patients with cerebral metastases from melanoma.

    abstract::Cerebral metastases from melanoma are correlated with a poor prognosis. Temozolomide is an oral alkylating agent that can cross the blood-brain barrier and in phase II and III trials, patients with advanced metastatic melanoma achieved overall response rates of 13 to 21%. The present study evaluated the efficacy and t...

    journal_title:Melanoma research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bafaloukos D,Tsoutsos D,Fountzilas G,Linardou H,Christodoulou C,Kalofonos HP,Briassoulis E,Panagiotou P,Hatzichristou H,Gogas H

    更新日期:2004-08-01 00:00:00

  • Surgical management of metastatic melanoma in the era of targeted systemic therapies.

    abstract::Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

    journal_title:Melanoma research

    pub_type: 杂志文章,评审


    authors: O'Leary DP,Byrnes KG,Power DG,Redmond HP

    更新日期:2015-02-01 00:00:00

  • Tissue counter analysis of dermatoscopic images of melanocytic skin tumours: preliminary findings.

    abstract::In tissue counter analysis, a novel image analysis tool in the evaluation of dermatoscopic images, a lattice of elementary measuring masks (elements) of equal size is randomly placed over the image and the contents of each element is evaluated by a set of colour and texture features. In this study, we tested the effic...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Kahofer P,Hofmann-Wellenhof R,Smolle J

    更新日期:2002-02-01 00:00:00

  • Mutation analysis of the MEN1 tumour suppressor gene in malignant melanoma.

    abstract::During the initiation and progression of malignant melanoma a series of genetic events accumulate, including alterations of chromosome 11q. Recently, an important tumour suppressor gene, the multiple endocrine neoplasia type 1 (MEN1) gene, has been mapped on 11q13 and has been cloned. To assess whether the MEN1 region...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Böni R,Vortmeyer AO,Huang S,Burg G,Hofbauer G,Zhuang Z

    更新日期:1999-06-01 00:00:00

  • Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment.

    abstract::Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Sztiller-Sikorska M,Koprowska K,Jakubowska J,Zalesna I,Stasiak M,Duechler M,Czyz ME

    更新日期:2012-06-01 00:00:00

  • Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation.

    abstract::Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged line...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Rozenberg GI,Monahan KB,Torrice C,Bear JE,Sharpless NE

    更新日期:2010-10-01 00:00:00

  • Superantigen-induced lysis of melanoma cells.

    abstract::Superantigens like the Staphylococcus enterotoxin A (SEA) can direct cytotoxic T lymphocytes expressing certain T cell receptor V beta regions to lyse MHC class II-positive target cells. This superantigen-dependent cellular cytotoxicity (SDCC) has been extended to MHC class II-negative tumour cells by targeting T cell...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Krull F,Holzer U,Ihle J,Bethge W,Fierlbeck G,Kalland T,Dohlsten M,Niethammer D,Dannecker GE

    更新日期:1997-06-01 00:00:00

  • Growth inhibition of subcutaneous mouse melanoma and induction of natural killer cells by liposome-mediated interferon-beta gene therapy.

    abstract::In this study we investigated the antitumour effect and mechanism of action of cationic liposome-mediated murine interferon-beta (IFNbeta) gene therapy in mouse B16F1 melanoma cells in vitro and in vivo. Murine IFNbeta gene transfer by cationic liposome resulted in substantial growth inhibition of B16F1 melanoma cells...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Ryuke Y,Mizuno M,Natsume A,Suzuki O,Nobayashi M,Kageshita T,Matsumoto K,Saida T,Yoshida J

    更新日期:2003-08-01 00:00:00

  • No indication for performing sentinel node biopsy in melanoma patients with a Breslow thickness of less than 0.9 mm.

    abstract::In thin melanomas, the involvement of regional nodes is very uncommon. Recent sentinel node (SN) studies have confirmed the absence of positive regional lymph nodes in melanomas < 0.76 mm and a 5% positivity in melanomas between 1.0 and 1.99 mm. The chance of regional lymph node involvement - and therefore whether it ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Statius Muller MG,van Leeuwen PA,van Diest PJ,Vuylsteke RJ,Pijpers R,Meijer S

    更新日期:2001-06-01 00:00:00

  • A single-centre experience of patients with metastatic melanoma enrolled in a dabrafenib named patient programme.

    abstract::We studied the efficacy, tolerability and clinical courses of dabrafenib in patients with metastatic melanoma who were ineligible for enrolment into a clinical trial. Between July 2011 and May 2013, patients with unresectable stage III or stage IV, V600-mutated metastatic melanoma who were not eligible for inclusion i...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Lau DK,Andrews MC,Turner N,Azad AA,Davis ID,Cebon JS

    更新日期:2014-04-01 00:00:00

  • Effective treatment of B16 melanoma by direct delivery of bleomycin using electrochemotherapy.

    abstract::Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agen...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Heller R,Jaroszeski M,Perrott R,Messina J,Gilbert R

    更新日期:1997-02-01 00:00:00

  • Immune-related Bell's palsy in melanoma patients treated with immune checkpoint inhibitors.

    abstract::Immune-checkpoint inhibitors (ICIs) exposed the oncology community to novel immune-related adverse events (irAEs). Here, we report on a retrospective analysis of patients with melanoma who developed an ICI-related, unilateral, acute and peripheral facial nerve paralysis (Bell's palsy).We retrospectively reviewed all t...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Beninato T,Fucà G,Di Guardo L,Vetrano I,Valeri B,Nesa F,Del Vecchio M,Cimminiello C

    更新日期:2021-01-22 00:00:00

  • Primary malignant melanoma of the esophagus.

    abstract::Primary malignant melanoma of the esophagus is an extremely rare, but highly aggressive, tumor. The prognosis for primary malignant melanoma of the esophagus remains dismal in most literatures. We report here a case of primary malignant melanoma of the esophagus that was treated by surgical resection and, additionally...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Yang X,Qu J,Wang S

    更新日期:2010-02-01 00:00:00

  • Comparative outcomes and toxicities for ruthenium-106 versus palladium-103 in the treatment of choroidal melanoma.

    abstract::For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Danish H,Ferris MJ,Balagamwala E,Switchenko JM,Patel KR,Choudhary M,Craven C,Mendoza P,Suh J,Bergstrom C,Grossniklaus HE,M Aaberg T Sr,Singh A,Crocker IR,Khan MK

    更新日期:2018-04-01 00:00:00

  • Different expression of lysosome-associated membrane protein-1 in human melanomas and benign melanocytic lesions.

    abstract::Lysosome-associated membrane protein-1 is a protein with a significant content of beta1,6-branched N-glycans. It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelia...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Kuźbicki L,Gajo B,Chwirot BW

    更新日期:2006-06-01 00:00:00

  • MAGE-12 and MAGE-6 are frequently expressed in malignant melanoma.

    abstract::MAGE proteins have been identified as potential specific targets for cancer vaccination. Although MAGE-6 and MAGE-12 were originally identified in malignant melanoma there are no studies reporting the frequency of expression of these antigens in this malignancy. These are of relevance particularly for MAGE-6 as recent...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Gibbs P,Hutchins AM,Dorian KT,Vaughan HA,Davis ID,Silvapulle M,Cebon JS

    更新日期:2000-06-01 00:00:00

  • Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells.

    abstract::Melanoma cells are unusual because, unlike most epithelial tumours, constitutive expression of HLA class II antigens is common. We have previously demonstrated that a peptide-specific CD4+ T-cell clone proliferates briskly in response to peptide and HLA class II expressing melanoma cell lines derived from metastases. ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Brady MS,Eckels DD,Lee F,Ree SY,Lee JS

    更新日期:1999-04-01 00:00:00

  • Cytotoxic effects of violacein in human uveal melanoma cell lines.

    abstract::Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Saraiva VS,Marshall JC,Cools-Lartigue J,Burnier MN Jr

    更新日期:2004-10-01 00:00:00

  • Lovastatin-induced apoptosis in human melanoma cell lines.

    abstract::The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell lines was examined by Cell T...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Shellman YG,Ribble D,Miller L,Gendall J,Vanbuskirk K,Kelly D,Norris DA,Dellavalle RP

    更新日期:2005-04-01 00:00:00