The left ventricle as the first site of uveal melanoma metastasis 13 years after treatment of the primary tumor.


:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the left ventricle as the first site of uveal melanoma recurrence 13 years after treatment of his primary tumor. The metastatic tumor was considered unresectable. We describe the patient's medical management over the next 3 years, the course of his disease, and the results of our review of the literature.


Melanoma Res


Melanoma research


Kolandjian NA,Patel SP,Papadopoulos NE,Bedikian AY




Has Abstract


2011-04-01 00:00:00












  • Elevated blood β-2 microglobulin is associated with tumor monosomy-3 in patients with primary uveal melanoma.

    abstract::Prognostic blood biomarkers for patients with uveal melanoma have not been identified. Tumor monosomy-3 is strongly associated with the development of metastatic disease. Tumor expression of human leukocyte antigen class I molecules and insulin-like growth factor (IGF)-1 receptor has also been associated with the deve...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Triozzi PL,Elson P,Aldrich W,Achberger S,Tubbs R,Biscotti CV,Singh AD

    更新日期:2013-02-01 00:00:00

  • Wishful thinking, unicentric empiricism and the everyday world of the medical melanomologist.

    abstract::Despite the general advances in the chemotherapy of malignancies, progress comes slow in the management of patients with disseminated melanoma. Unreflected enthusiasm and frustrated scepticism are the scylla and charybdis between which the physician tries to choose the right way. ...

    journal_title:Melanoma research

    pub_type: 杂志文章,评审


    authors: Kleeberg UR

    更新日期:1997-08-01 00:00:00

  • A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma.

    abstract::A proportion of patients diagnosed with melanoma has a positive family history. Despite increasing knowledge on the genes responsible for familial clustering, the genetic basis in the majority of the families with an inherited predisposition to melanoma remains to be clarified. To identify novel melanoma-susceptibilit...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Salgado C,Kwesi-Maliepaard EM,Jochemsen AG,Visser M,Harland M,van Leeuwen F,van Doorn R,Gruis N

    更新日期:2019-12-01 00:00:00

  • Phase II randomized study of dacarbazine, carmustine, cisplatin and tamoxifen versus dacarbazine alone in advanced melanoma patients.

    abstract::This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BC...

    journal_title:Melanoma research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chiarion Sileni V,Nortilli R,Aversa SM,Paccagnella A,Medici M,Corti L,Favaretto AG,Cetto GL,Monfardini S

    更新日期:2001-04-01 00:00:00

  • Different expression of lysosome-associated membrane protein-1 in human melanomas and benign melanocytic lesions.

    abstract::Lysosome-associated membrane protein-1 is a protein with a significant content of beta1,6-branched N-glycans. It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelia...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Kuźbicki L,Gajo B,Chwirot BW

    更新日期:2006-06-01 00:00:00

  • Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma.

    abstract::The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...

    journal_title:Melanoma research

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Garbe C,Hauschild A,Volkenandt M,Schadendorf D,Stolz W,Reinhold U,Kortmann RD,Kettelhack C,Frerich B,Keilholz U,Dummer R,Sebastian G,Tilgen W,Schuler G,Mackensen A,Kaufmann R

    更新日期:2008-02-01 00:00:00

  • The prognostic role of CD4+ and CD8+ lymphocytes during chemoimmunotherapy in metastatic melanoma.

    abstract::We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

    更新日期:2004-12-01 00:00:00

  • Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells.

    abstract::Melanoma cells are unusual because, unlike most epithelial tumours, constitutive expression of HLA class II antigens is common. We have previously demonstrated that a peptide-specific CD4+ T-cell clone proliferates briskly in response to peptide and HLA class II expressing melanoma cell lines derived from metastases. ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Brady MS,Eckels DD,Lee F,Ree SY,Lee JS

    更新日期:1999-04-01 00:00:00

  • Spontaneous regression of metastases from melanoma: review of the literature.

    abstract::Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unkno...

    journal_title:Melanoma research

    pub_type: 杂志文章,评审


    authors: Kalialis LV,Drzewiecki KT,Klyver H

    更新日期:2009-10-01 00:00:00

  • Alkylating benzamides with melanoma cytotoxicity.

    abstract::Radioiodinated N-(2-(diethylamino)ethyl)benzamides have recently been discovered as selective agents for melanotic melanoma and are used for scintigraphic imaging in nuclear medicine. Owing to the high binding capacity, benzamide derivatives conjugated with alkylating cytostatics were synthesized and tested for their ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Wolf M,Bauder-Wüst U,Mohammed A,Schönsiegel F,Mier W,Haberkorn U,Eisenhut M

    更新日期:2004-10-01 00:00:00

  • Results of cisplatin hyperthermic isolation perfusion for stage IIIA and IIIAB extremity melanoma.

    abstract::Between 1983 and 1992, 21 patients with extremity stage IIIA or IIIAB melanoma underwent hyperthermic isolation limb perfusion (HILP) with cisplatin in dosages varying from 26 to 237 mg/m2 as part of a pharmacokinetics and maximum-tolerated dose study. Extremity temperatures were up to 40 degrees C and the pH was cont...

    journal_title:Melanoma research

    pub_type: 临床试验,杂志文章


    authors: Fletcher WS,Pommier R,Small K

    更新日期:1994-03-01 00:00:00

  • Nevi and Breslow thickness in melanoma: sex differences?

    abstract::A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

    更新日期:2020-04-01 00:00:00

  • Malignant melanoma and pregnancy.

    abstract::The occurrence of cancer in pregnant women is not a common phenomenon and the real incidence of malignant melanoma during this period is unknown. Many authors reported a poor prognosis in pregnant women with melanoma compared with non-pregnant women's tumour. Several retrospective reviews reported a worsened prognosis...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Silipo V,De Simone P,Mariani G,Buccini P,Ferrari A,Catricala C

    更新日期:2006-12-01 00:00:00

  • Parallel risk assessment of melanoma and basal cell carcinoma: skin characteristics and sun exposure.

    abstract::In this study we compared the strength of the association of constitutional factors and sun exposure with cutaneous malignant melanoma (CMM) and basal cell carcinoma (BCC). We analysed 260 incident cases of CMM, 425 incident cases of BCC and two sets of population controls from previous case-control studies conducted ...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Rosso S,Zanetti R,Pippione M,Sancho-Garnier H

    更新日期:1998-12-01 00:00:00

  • Tissue counter analysis of dermatoscopic images of melanocytic skin tumours: preliminary findings.

    abstract::In tissue counter analysis, a novel image analysis tool in the evaluation of dermatoscopic images, a lattice of elementary measuring masks (elements) of equal size is randomly placed over the image and the contents of each element is evaluated by a set of colour and texture features. In this study, we tested the effic...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Kahofer P,Hofmann-Wellenhof R,Smolle J

    更新日期:2002-02-01 00:00:00

  • Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight.

    abstract::The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

    更新日期:1997-12-01 00:00:00

  • Production of superoxide by human malignant melanoma cells.

    abstract::Metastasis is a complicated multi-step process involving interactions between tumour cells, the extracellular matrix and the vessel walls. Experimental observations suggest that leucocyte migration and function could be a suitable model in order to understand tumour cell dissemination. In the present report we show an...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Bittinger F,González-García JL,Klein CL,Brochhausen C,Offner F,Kirkpatrick CJ

    更新日期:1998-10-01 00:00:00

  • Dacarbazine with or without oblimersen (a Bcl-2 antisense oligonucleotide) in chemotherapy-naive patients with advanced melanoma and low-normal serum lactate dehydrogenase: 'The AGENDA trial'.

    abstract::In a previous large randomized, open-label study, retrospective subset analysis revealed that the addition of the Bcl-2 antisense oligonucleotide oblimersen to dacarbazine (Dac) significantly improved overall survival, progression-free survival, and the response rate in chemotherapy-naive patients with advanced melano...

    journal_title:Melanoma research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bedikian AY,Garbe C,Conry R,Lebbe C,Grob JJ,Genasense Melanoma Study Group.

    更新日期:2014-06-01 00:00:00

  • Effect of pEgr-TNFalpha gene radiotherapy on mice melanoma.

    abstract::In the present study, we constructed a pEgr-tumour necrosis factor-alpha (TNFalpha) plasmid and investigated its expression properties in B16 cells on exposure to ionizing irradiation and, furthermore, the effect of gene radiotherapy on a melanoma model. Firstly, the recombinant pEgr-TNFalpha plasmid was constructed a...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Wu C,Li X,Tian M

    更新日期:2005-06-01 00:00:00

  • Mapping of occult melanoma micrometastases in the inguinal lymph node basin by immunohistochemistry and RT-PCR.

    abstract::To examine the distribution of occult micrometastases that could be potential sources of recurrence, complete maps of microscopic and submicroscopic metastases in entire inguinal lymph node basins were generated in 13 melanoma patients who had undergone elective or therapeutic lymphadenectomy. Occult micrometastases w...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Hatta N,Fujimoto A,Takehara K,Takata M

    更新日期:1999-08-01 00:00:00

  • Clonal heterogeneity of melanoma in a paradigmatic case study: future prospects for circulating melanoma cells.

    abstract::The management of metastatic melanoma is a difficult matter. Nevertheless, the advent of target therapy has significantly improved patient outcome, provided that tumor molecular characteristics become available: the detection of drug-resistant clones can contribute to understanding the reasons for resistance onset, in...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Scaini MC,Pigozzo J,Pizzi M,Manicone M,Chiarion-Sileni V,Zambenedetti P,Rugge M,Zanovello P,Rossi E,Zamarchi R,Facchinetti A

    更新日期:2019-02-01 00:00:00

  • F-18 fluorodeoxy-D-glucose positron emission tomography scan in the initial evaluation of patients with a primary melanoma thicker than 4 mm.

    abstract::Metabolic imaging with F-18 fluorodeoxy-D-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. We designed, in 2004, at the Institute Gustave Roussy, a prospective study to determine the value of F-18 fluorodeoxy-D-glucose positron emission t...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Maubec E,Lumbroso J,Masson F,Suciu V,Kolb F,Mamelle G,Cavalcanti A,Boitier F,Spatz A,Aupérin A,Leboulleux S,Avril MF

    更新日期:2007-06-01 00:00:00

  • Cytokeratin expression in malignant melanoma: potential application of in-situ hybridization analysis of mRNA.

    abstract::Occasional reports indicated cytokeratin (CK) protein expression (mainly by immunohistochemistry) in malignant melanoma (MM) and suggested an association with unfavorable clinical parameters. However, the mRNA expression of CK and its clinicopathologic significance in MM has not been specifically evaluated. We investi...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Chen N,Gong J,Chen X,Xu M,Huang Y,Wang L,Geng N,Zhou Q

    更新日期:2009-04-01 00:00:00

  • Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.

    abstract::Glutathione (GSH) is the major non-protein thiol in cells that plays a critical role against damage from electrophilic agents such as alkylating drugs. Selective therapeutic GSH elevation in normal but not in tumour cells has been suggested as a means of protecting host tissues against more intense doses of chemothera...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: del Olmo M,Alonso-Varona A,Castro B,Calle Y,Bilbao P,Palomares T

    更新日期:2000-04-01 00:00:00

  • A case of acute paraneoplastic neurological syndrome in BRAF mutant metastatic melanoma.

    abstract::A 58-year-old man with indolent metastatic BRAF mutant melanoma presented with several days' history of progressive ataxia and dysdiadochokinesia. His PET/computed tomography restaging scan indicated two new fluorine-18-fluorodeoxyglucose-avid mesenteric lymph nodes. Meanwhile, his MRI brain and whole spine were withi...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Lee SF,Atkinson V

    更新日期:2016-08-01 00:00:00

  • 20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas.

    abstract::The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Bellocq D,Roy P,Kodjikian L,Mathis T,Nguyen AM,Herault J,Rivoire M,Négrier S,Thariat J,Grange JD

    更新日期:2020-06-01 00:00:00

  • A purified GM3 ganglioside conjugated vaccine induces specific, adjuvant-dependent and non-transient antitumour activity against B16 mouse melanoma in vitro and in vivo.

    abstract::The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Carr A,Mazorra Z,Alonso DF,Mesa C,Valiente O,Gomez DE,Perez R,Fernandez LE

    更新日期:2001-06-01 00:00:00

  • Asymptomatic brain metastases in patients with cutaneous metastatic malignant melanoma.

    abstract::The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Zukauskaite R,Schmidt H,Asmussen JT,Hansen O,Bastholt L

    更新日期:2013-02-01 00:00:00

  • Effects of interferon-alpha, verapamil and dacarbazine in the treatment of advanced malignant melanoma.

    abstract::Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%. This study evaluated the activity and toxicity following treatment with a combination of DTIC, IFNalpha2b and verapamil (V...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Andersson R,Ake Hofer P,Riklund-Ahlström K,Henriksson R

    更新日期:2003-02-01 00:00:00

  • Pelvic computed tomography scans for surveillance in patients with primary melanoma in the head and neck.

    abstract::Although pelvic computed tomography (CT) scans are frequently performed as a part of routine surveillance, the evidence for or against the routine use of these scans in patients with primary melanoma in the head and neck is weak. We conducted a retrospective study to evaluate the value of pelvic CT scans as routine su...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Alvarado GC,Papadopoulos NE,Hwu WJ,Bedikian AY,Homsi J,Myers JN,Bronstein Y,Bassett RL,Hwu P,Kim KB

    更新日期:2011-04-01 00:00:00