Elevated rates of transaminitis during ipilimumab therapy for metastatic melanoma.

abstract：:Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We ...

journal_title：Melanoma research

authors： Caini S,Gandini S,Botta F,Tagliabue E,Raimondi S,Nagore E,Zanna I,Maisonneuve P,Newton-Bishop J,Polsky D,Lazovich D,Kumar R,Kanetsky PA,Hoiom V,Ghiorzo P,Landi MT,Ribas G,Menin C,Stratigos AJ,Palmieri G,Guida G,

更新日期：2020-10-01 00:00:00

abstract：:Dissemination of uveal melanomas is almost exclusively haematogenous, making angiogenesis of the tumour a prerequisite for the formation of metastases. Uveal melanomas must employ strategies to evade the immune system in order to escape immune surveillance. We therefore determined the expression of the following angio...

journal_title：Melanoma research

authors： Ijland SA,Jager MJ,Heijdra BM,Westphal JR,Peek R

更新日期：1999-10-01 00:00:00

abstract：:Anorectal malignant melanoma is an uncommon tumour. Unlike for cutaneous melanoma, there are few guidelines for its optimal management. In particular, very few palliative treatment strategies have been described for patients with advanced disease. We report on an 80 year old patient with locally advanced anorectal mel...

journal_title：Melanoma research

authors： Ulmer A,Metzger S,Fierlbeck G

更新日期：2002-08-01 00:00:00

abstract：:Metastasis is a complicated multi-step process involving interactions between tumour cells, the extracellular matrix and the vessel walls. Experimental observations suggest that leucocyte migration and function could be a suitable model in order to understand tumour cell dissemination. In the present report we show an...

journal_title：Melanoma research

authors： Bittinger F,González-García JL,Klein CL,Brochhausen C,Offner F,Kirkpatrick CJ

更新日期：1998-10-01 00:00:00

abstract：:Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progression, we hypothesized that these promoter SNPs might affect CM p...

journal_title：Melanoma research

authors： Liu H,Wei Q,Gershenwald JE,Prieto VG,Lee JE,Duvic M,Grimm EA,Wang LE

更新日期：2012-04-01 00:00:00

abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...

journal_title：Melanoma research

authors： Abbott JL,Qureshi MM,Truong MT,Sahni D

更新日期：2019-08-01 00:00:00

abstract：:Melanoma tumors have been shown to comprise both invasive and proliferative cell subpopulations. These populations are highly plastic, thus hampering full characterization and therapeutic targeting of dormant and partially dedifferentiated invasive cells. We have reported, previously, that melanoma cells grown in a se...

journal_title：Melanoma research

authors： Ghislin S,Deshayes F,Lauriol J,Middendorp S,Martins I,Al-Daccak R,Alcaide-Loridan C

更新日期：2012-06-01 00:00:00

abstract：:This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BC...

journal_title：Melanoma research

authors： Chiarion Sileni V,Nortilli R,Aversa SM,Paccagnella A,Medici M,Corti L,Favaretto AG,Cetto GL,Monfardini S

更新日期：2001-04-01 00:00:00

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the l...

journal_title：Melanoma research

authors： Kolandjian NA,Patel SP,Papadopoulos NE,Bedikian AY

更新日期：2011-04-01 00:00:00

abstract：:Although pelvic computed tomography (CT) scans are frequently performed as a part of routine surveillance, the evidence for or against the routine use of these scans in patients with primary melanoma in the head and neck is weak. We conducted a retrospective study to evaluate the value of pelvic CT scans as routine su...

journal_title：Melanoma research

authors： Alvarado GC,Papadopoulos NE,Hwu WJ,Bedikian AY,Homsi J,Myers JN,Bronstein Y,Bassett RL,Hwu P,Kim KB

更新日期：2011-04-01 00:00:00

abstract：:An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longi...

journal_title：Melanoma research

authors： Olsen CM,Lane SW,Green AC

更新日期：2016-04-01 00:00:00

abstract：:Germline mutations determining increased cutaneous malignant melanoma (CMM) risk have been identified in familial and sporadic CMM cases, but they account only for a small proportion of CMM cases. Recent evidence suggests that germline epimutations (e.g. DNA methylation alterations), which can be inherited similarly t...

journal_title：Melanoma research

authors： Pergoli L,Favero C,Pfeiffer RM,Tarantini L,Calista D,Cavalleri T,Angelici L,Consonni D,Bertazzi PA,Pesatori AC,Landi MT,Bollati V

更新日期：2014-10-01 00:00:00

abstract：:The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of ...

journal_title：Melanoma research

authors： Kleemann J,Hrgovic I,Ter-Nedden J,Kleimann P,Steinhorst K,Härle K,Müller J,Kaufmann R,Meissner M,Kippenberger S

更新日期：2018-08-01 00:00:00

abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

journal_title：Melanoma research

authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

更新日期：2016-06-01 00:00:00

abstract：:Protein tyrosyl phosphorylation is an essential component in intracellular signalling, with diverse and crucial functions including mediation of cell proliferation, survival, death, differentiation, migration and attachment. It is regulated by the balance between the activities of protein tyrosine kinases (PTKs) and p...

journal_title：Melanoma research

authors： Easty DJ,Bennett DC

更新日期：2000-10-01 00:00:00

abstract：:Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a...

journal_title：Melanoma research

authors： Schartz NE,Farges C,Madelaine I,Bruzzoni H,Calvo F,Hoos A,Lebbé C

更新日期：2010-06-01 00:00:00

abstract：:Melanomas contain subsets of cancer stem-like cells with tumor-initiating capacity. The frequency of these cells in the tumor is still a topic of debate. We investigated the phenotypic plasticity of cancer cells grown as melanospheres to elucidate the influence of the microenvironment on some features of melanoma stem...

journal_title：Melanoma research

authors： Sztiller-Sikorska M,Koprowska K,Jakubowska J,Zalesna I,Stasiak M,Duechler M,Czyz ME

更新日期：2012-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melano...

journal_title：Melanoma research

authors： Glud M,Manfé V,Biskup E,Holst L,Dirksen AM,Hastrup N,Nielsen FC,Drzewiecki KT,Gniadecki R

更新日期：2011-06-01 00:00:00

abstract：:BRAF mutations are found in ~50% of metastatic melanomas, most commonly in codon V600. Vemurafenib improves progression-free survival and overall survival in patients with advanced BRAF-mutated melanoma. The results of a descriptive study evaluating vemurafenib in patients with advanced melanoma harbouring BRAF mutati...

journal_title：Melanoma research

authors： Hallmeyer S,Gonzalez R,Lawson DH,Cranmer LD,Linette GP,Puzanov I,Taback B,Cowey CL,Ribas A,Daniels GA,Moore T,Gibney GT,Tawbi H,Whitman E,Lee G,Mun Y,Liu S,Hamid O

更新日期：2017-12-01 00:00:00

abstract：:The management of melanoma brain metastases (MBM) includes different therapeutic modalities, such as surgery, radiotherapy and chemotherapy. Despite the choice of treatments, survival remains poor, exceeding 1 year only in patients with solitary metastases and absence of extracranial disease. A total of 115 consecutiv...

journal_title：Melanoma research

authors： Vecchio S,Spagnolo F,Merlo DF,Signori A,Acquati M,Pronzato P,Queirolo P

更新日期：2014-02-01 00:00:00

abstract：:Several comparative genomic hybridization studies provide evidence for overrepresentation of the long arm of chromosome 20 in malignant melanoma. These studies also suggest that chromosome 20q contains genes that may contribute to melanoma pathogenesis. To refine the region of 20q amplification and to identify potenti...

journal_title：Melanoma research

authors： Koynova DK,Jordanova ES,Milev AD,Dijkman R,Kirov KS,Toncheva DI,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00

abstract：:Lymphoscintigraphy (LS) has been performed for 8 years in patients of the Sydney Melanoma Unit, to define lymphatic drainage patterns. Over the past 2 years, LS has also been used to locate the sentinel lymph node prior to surgery. Our technique for LS and subsequent sentinel node biopsy has an accuracy of 97%. All se...

journal_title：Melanoma research

authors： Uren RF,Howman-Giles R,Thompson JF,Shaw HM,Quinn MJ,O'Brien CJ,McCarthy WH

更新日期：1994-12-01 00:00:00

abstract：:Concurrent BRAF-MEK inhibition improves clinical outcomes in patients with advanced BRAF V600E/K-mutant melanoma. There is currently less evidence for the efficacy of this treatment in patients with rare BRAF non-V600E/K genotypes. We report on two patients with rare BRAF exon 15 mutations - BRAF A598_T599insV and V60...

journal_title：Melanoma research

authors： Rogiers A,Vander Borght S,Tuand K,Wolter P,Stas M,Boecxstaens V,Garmyn M,van den Oord JJ,Vandenberghe P,Bechter O

更新日期：2017-10-01 00:00:00

abstract：:The cell surface glycoprotein MUC18 was originally identified as a progression associated antigen in melanoma. MUC18 is expressed most strongly on metastatic lesions and advanced primary tumours and is only rarely detected in benign lesions. cDNA cloning revealed MUC18 to be a novel member of the immunoglobulin superf...

journal_title：Melanoma research

authors： Johnson JP,Rothbächer U,Sers C

更新日期：1993-10-01 00:00:00

abstract：:Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masqueradi...

journal_title：Melanoma research

authors： Moshe M,Levi A,Ad-El D,Ben-Amitai D,Mimouni D,Didkovsky E,Feinmesser M,Lapidoth M

更新日期：2018-08-01 00:00:00

abstract：:In thin melanomas, the involvement of regional nodes is very uncommon. Recent sentinel node (SN) studies have confirmed the absence of positive regional lymph nodes in melanomas < 0.76 mm and a 5% positivity in melanomas between 1.0 and 1.99 mm. The chance of regional lymph node involvement - and therefore whether it ...

journal_title：Melanoma research

authors： Statius Muller MG,van Leeuwen PA,van Diest PJ,Vuylsteke RJ,Pijpers R,Meijer S

更新日期：2001-06-01 00:00:00

abstract：:An inactive cathepsin B-like enzyme with a molecular mass of 40 kD was found in a human melanoma culture medium. The inactive form of this enzyme was converted into an active form with a molecular mass of 28 kD by pepsin treatment. This activated cathepsin B-like enzyme had almost the same characteristics regarding mo...

journal_title：Melanoma research

authors： Tsushima H,Hyodoh F,Yoshida E,Ueki A,Hopsu-Havu VK

更新日期：1992-01-01 00:00:00

abstract：:CD8 T-cell infiltration of metastatic melanoma may be a useful biomarker for prediction of prognosis and response to therapy. The heterogeneous distribution of CD8 T cells within a single tumor, and across different tumors within a single patient, may complicate quantification of infiltration. However, the impact of h...

journal_title：Melanoma research

authors： Obeid JM,Hu Y,Erdag G,Leick KM,Slingluff CL Jr

更新日期：2017-06-01 00:00:00