Abstract:
:Lymphoscintigraphy (LS) has been performed for 8 years in patients of the Sydney Melanoma Unit, to define lymphatic drainage patterns. Over the past 2 years, LS has also been used to locate the sentinel lymph node prior to surgery. Our technique for LS and subsequent sentinel node biopsy has an accuracy of 97%. All sentinel nodes must be marked to ensure the successful application of the sentinel biopsy technique. We have found that the axilla and groin average just over one sentinel node per draining node group for lesions on the trunk and upper limb, but have noted that drainage to the groin differed when lower limb lesions were studied. Because of the anastomosis of lymph vessels in the upper thigh, multiple sentinel nodes are identified in the groin in some patients. We have found an average of three sentinel nodes in the groin when lymph drainage from lower limb lesions was studied with LS. This difference demands a modification of the LS technique, with early imaging of the groin nodes to identify all sentinel nodes in each patient. The depth of the sentinel nodes can also be measured and the location of all interval nodes marked on the skin. This ensures that all sentinel nodes and interval nodes can be removed at the time of surgery.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Uren RF,Howman-Giles R,Thompson JF,Shaw HM,Quinn MJ,O'Brien CJ,McCarthy WHdoi
10.1097/00008390-199412000-00009subject
Has Abstractpub_date
1994-12-01 00:00:00pages
395-9issue
6eissn
0960-8931issn
1473-5636journal_volume
4pub_type
杂志文章abstract::Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on thi...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000391
更新日期:2017-12-01 00:00:00
abstract::Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progression, we hypothesized that these promoter SNPs might affect CM p...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32834fc46b
更新日期:2012-04-01 00:00:00
abstract::Melanoma is the deadliest form of skin cancer. Ipilimumab, a novel immunotherapy, is the first treatment shown to improve survival in patients with metastatic melanoma in large randomized controlled studies. The most concerning side effects reported in clinical studies of ipilimumab fall into the category of immune-re...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32835c7e68
更新日期:2013-02-01 00:00:00
abstract::To our knowledge modulation of the expression of tumour necrosis factor-alpha (TNF-alpha) in malignant melanoma metastases in vivo has not been reported. The expression of TNF-alpha by malignant melanoma cells was studied immunohistochemically using an anti-TNF-alpha antibody. The specificity of the staining reaction ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199704000-00008
更新日期:1997-04-01 00:00:00
abstract::Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000634
更新日期:2020-06-01 00:00:00
abstract::Accurate staging of patients with primary cutaneous melanoma includes assessment of regional lymph nodes for the presence of micrometastatic disease. Sentinel lymph node biopsy is highly accurate but is an invasive surgical procedure with a 5-10% complication rate, and requires labour-intensive and expensive histologi...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200306000-00006
更新日期:2003-06-01 00:00:00
abstract::Seasonal variation in melanoma diagnoses has been observed in numerous studies that used calendar time indicators. Depending on the latitude (and altitude) of the study region, the magnitude of seasonal and year-to-year variation of ultraviolet radiation (UVR) is neglected in these studies. An alternative approach com...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000205
更新日期:2015-12-01 00:00:00
abstract::We studied the efficacy, tolerability and clinical courses of dabrafenib in patients with metastatic melanoma who were ineligible for enrolment into a clinical trial. Between July 2011 and May 2013, patients with unresectable stage III or stage IV, V600-mutated metastatic melanoma who were not eligible for inclusion i...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000036
更新日期:2014-04-01 00:00:00
abstract::Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique is potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen patient...
journal_title:Melanoma research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00008390-200502000-00008
更新日期:2005-02-01 00:00:00
abstract::Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years of immunosuppression with azathioprine and prednisolone. The patient died of metastatic disease 3 months after the diagnosis was made. The function of the renal...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e32831bc44a
更新日期:2009-08-01 00:00:00
abstract::Lysosome-associated membrane protein-1 is a protein with a significant content of beta1,6-branched N-glycans. It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelia...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000215034.00318.7a
更新日期:2006-06-01 00:00:00
abstract::Ipilimumab is approved for adjuvant melanoma treatment at a dose of 10 mg/kg, but its use is limited owing to high toxicity and treatment-associated costs. We retrospectively analyzed 29 patients who underwent complete resection of stage IIC-III melanoma and were treated with ipilimumab 3 mg/kg in an adjuvant setting....
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000593
更新日期:2019-12-01 00:00:00
abstract::Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200104000-00005
更新日期:2001-04-01 00:00:00
abstract::Conjunctival melanoma is a rare disease, and little is known about its molecular background. Here, we present the case of a 48-year-old patient with conjunctival melanoma and metachronic lymph node and skin metastasis with KRAS p.K117Y mutation in exon 4 in all the lesions. The cancer genome interpreter predicted this...
journal_title:Melanoma research
pub_type: 杂志文章,评审
doi:10.1097/CMR.0000000000000423
更新日期:2018-04-01 00:00:00
abstract::The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition i...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000174
更新日期:2015-10-01 00:00:00
abstract::Levels of eumelanin (EM) and pheomelanin (PM) of uveal melanoma cells have not been measured and compared with those of normal uveal melanocytes. EM and PM amounts in four immortal human uveal melanoma cell lines were measured by chemical degradation and microanalytical high-performance liquid chromatography and compa...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328329ae49
更新日期:2009-04-01 00:00:00
abstract::An increased risk of melanoma has been variously reported in patients with chronic lymphocytic leukaemia (CLL), analogous with other immunosuppressed populations. To fully assess this association, we performed a systematic review and meta-analysis of available evidence from observational cohort studies. All such longi...
journal_title:Melanoma research
pub_type: 杂志文章,meta分析,评审
doi:10.1097/CMR.0000000000000219
更新日期:2016-04-01 00:00:00
abstract::For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000420
更新日期:2018-04-01 00:00:00
abstract::This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germa...
journal_title:Melanoma research
pub_type: 杂志文章,多中心研究
doi:10.1097/00008390-199404000-00001
更新日期:1994-04-01 00:00:00
abstract::The concept of 'vasculogenic mimicry' (VM) was introduced to describe the unique ability of highly invasive tumor cells to form capillary-like structures (CLS) and matrix-rich patterned network in three-dimensional culture that mimic embryonic vasculogenic network. Recently, we have shown that CLS formation requires a...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282f1d2ec
更新日期:2007-12-01 00:00:00
abstract::A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000579
更新日期:2020-04-01 00:00:00
abstract::Checkpoint inhibitor immunotherapy is a transformative treatment for advanced malignancies, but can be associated with numerous immune-related adverse events (irAEs). The majority of irAEs include those that closely resemble known cutaneous and neurocutaneous autoimmune or autoinflammatory diseases, such as scleroderm...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000642
更新日期:2020-06-01 00:00:00
abstract::The aim of this study was to evaluate metastatic latency and survival after the occurrence of metastases in patients with choroidal/ciliary body melanoma treated with proton therapy. This was a retrospective cohort study. All consecutive patients with choroidal/ciliary body melanoma treated with proton therapy between...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000519
更新日期:2020-06-01 00:00:00
abstract::The mechanism of action of fotemustine, a relatively new chloroethylnitrosourea, was evaluated in human melanoma cells in order to assess its potential as an agent for hyperthermic limb perfusion. Fotemustine was more toxic to O6-alkylguanine methyl transferase (AGT) deficient (Mer-) cells than Mer+ cells, implicating...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199802000-00012
更新日期:1998-02-01 00:00:00
abstract::Immunotherapy with anti-programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Octogenarians and nonagenarians represent a significant cohort of melanoma patients. This multicenter retrospective analysis enrolled 499 patients treated with nivolumab or pembrolizumab. Seventy-three pati...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000705
更新日期:2021-02-01 00:00:00
abstract::M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the relationship with tumor progression and known prognostic parameters. Fifty-...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328363e4ab
更新日期:2013-10-01 00:00:00
abstract::During the initiation and progression of malignant melanoma a series of genetic events accumulate, including alterations of chromosome 11q. Recently, an important tumour suppressor gene, the multiple endocrine neoplasia type 1 (MEN1) gene, has been mapped on 11q13 and has been cloned. To assess whether the MEN1 region...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-199906000-00006
更新日期:1999-06-01 00:00:00
abstract::Acral lentiginous melanoma (ALM) is the most frequent type of cutaneous melanoma in the Asian and African populations, but the fourth distinct variant of cutaneous melanoma in the Caucasian population. Histological criteria and prognosis of ALM remain controversial. A retrospective study, showing epidemiological, clin...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282f1d2b6
更新日期:2010-06-25 00:00:00
abstract::The management of melanoma brain metastases (MBM) includes different therapeutic modalities, such as surgery, radiotherapy and chemotherapy. Despite the choice of treatments, survival remains poor, exceeding 1 year only in patients with solitary metastases and absence of extracranial disease. A total of 115 consecutiv...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0000000000000029
更新日期:2014-02-01 00:00:00
abstract::Patients with melanoma may experience a variety of different vision symptoms, in part associated with melanoma-associated retinopathy. For several melanoma patients with or without melanoma-associated retinopathy, colour vision deficiencies, especially involving the tritan system, have been reported. The frequency of ...
journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/01.cmr.0000222599.35062.84
更新日期:2006-10-01 00:00:00