Different expression of lysosome-associated membrane protein-1 in human melanomas and benign melanocytic lesions.


:Lysosome-associated membrane protein-1 is a protein with a significant content of beta1,6-branched N-glycans. It is thought that enhanced expression of lysosome-associated membrane protein-1 in tumour cells may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelial cells. The present study was aimed at examining levels of lysosome-associated membrane protein-1 in human melanomas and benign pigmented lesions to evaluate whether this protein might be considered a potential molecular marker of melanoma progression. The expression of lysosome-associated membrane protein-1 was for the first time determined immunohistochemically in formalin-fixed paraffin-embedded specimens comprising 42 primary cutaneous melanomas, 15 lymph node melanoma metastases (11 correlated with primary tumours), three melanoma recurrences (correlated with both primary and metastatic melanomas), 27 nevi and four epithelial tumours (two seborrhoeic keratoses and two basal cell carcinomas). Our results demonstrate that development and progression of melanoma are associated with changes of the lysosome-associated membrane protein-1 level. The expression was strongest in melanoma recurrences and lymph node metastases, weaker in primary cutaneous melanomas and not detectable in melanocytes of pigmented nevi. Nodular melanomas expressed lysosome-associated membrane protein-1 at higher level than superficially spreading melanomas.


Melanoma Res


Melanoma research


Kuźbicki L,Gajo B,Chwirot BW




Has Abstract


2006-06-01 00:00:00














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    pub_type: 杂志文章


    authors: Pirker C,Holzmann K,Spiegl-Kreinecker S,Elbling L,Thallinger C,Pehamberger H,Micksche M,Berger W

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    authors: Kahofer P,Hofmann-Wellenhof R,Smolle J

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    authors: Xu Y,Zhang F,Qin L,Miao J,Sheng W,Xie Y,Xu X,Yang J,Qian H

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    更新日期:2019-08-01 00:00:00

  • Anti-programmed cell death-1 therapy in octogenarian and nonagenarian advanced/metastatic melanoma patients.

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    authors: Cybulska-Stopa B,Ziętek M,Kamińska-Winciorek G,Czarnecka AM,Piejko K,Galus Ł,Ziółkowska B,Kieszko S,Kempa-Kamińska N,Calik J,Zemełka T,Kubiatowski T,Suwiński R,Mackiewicz J,Rutkowski P

    更新日期:2021-02-01 00:00:00

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    journal_title:Melanoma research

    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    更新日期:2005-02-01 00:00:00

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    journal_title:Melanoma research

    pub_type: 杂志文章,评审


    authors: Valenzano Menada M,Moioli M,Garaventa A,Nozza P,Foppiano M,Trimarchi N,Fulcheri E

    更新日期:2010-12-01 00:00:00

  • Routine retrieval of pelvic sentinel lymph nodes for melanoma rarely adds prognostic information or alters management.

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Swords DS,Andtbacka RHI,Bowles TL,Hyngstrom JR

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Silipo V,De Simone P,Mariani G,Buccini P,Ferrari A,Catricala C

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Brady MS,Eckels DD,Lee F,Ree SY,Lee JS

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Wu ZY,Smithers BM,Anderson C,Roberts MS

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Adams G,Foote M,Brown S,Burmeister B

    更新日期:2017-02-01 00:00:00

  • Results obtained by using a computerized image analysis system designed as an aid to diagnosis of cutaneous melanoma.

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    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Cascinelli N,Ferrario M,Bufalino R,Zurrida S,Galimberti V,Mascheroni L,Bartoli C,Clemente C

    更新日期:1992-09-01 00:00:00

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    abstract::Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged line...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Rozenberg GI,Monahan KB,Torrice C,Bear JE,Sharpless NE

    更新日期:2010-10-01 00:00:00

  • A purified GM3 ganglioside conjugated vaccine induces specific, adjuvant-dependent and non-transient antitumour activity against B16 mouse melanoma in vitro and in vivo.

    abstract::The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Carr A,Mazorra Z,Alonso DF,Mesa C,Valiente O,Gomez DE,Perez R,Fernandez LE

    更新日期:2001-06-01 00:00:00

  • Melanoma vasculogenic mimicry is strongly related to reactive oxygen species level.

    abstract::The concept of 'vasculogenic mimicry' (VM) was introduced to describe the unique ability of highly invasive tumor cells to form capillary-like structures (CLS) and matrix-rich patterned network in three-dimensional culture that mimic embryonic vasculogenic network. Recently, we have shown that CLS formation requires a...

    journal_title:Melanoma research

    pub_type: 杂志文章


    authors: Vartanian AA,Burova OS,Stepanova EV,Baryshnikov AY,Lichinitser MR

    更新日期:2007-12-01 00:00:00