Production of superoxide by human malignant melanoma cells.

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expression of miRNA-125b (miR-125b) was two-fold lower in malignant melano...

journal_title：Melanoma research

authors： Glud M,Manfé V,Biskup E,Holst L,Dirksen AM,Hastrup N,Nielsen FC,Drzewiecki KT,Gniadecki R

更新日期：2011-06-01 00:00:00

abstract：:Melanoma is among the most chemotherapy-resistant malignancies. Numerous new agents have been developed that target specific molecules on cancer cells, including the monoclonal antibody trastuzumab, which targets Her2/neu and has been very beneficial in the treatment of breast cancer. There are conflicting reports in ...

journal_title：Melanoma research

authors： Kluger HM,DiVito K,Berger AJ,Halaban R,Ariyan S,Camp RL,Rimm DL

更新日期：2004-06-01 00:00:00

abstract：:Several hypotheses have explicitly implicated the role of an altered redox status of melanin in the aetiology of melanoma and macular degeneration. The balance between the intrinsic anti-oxidant and pro-oxidant properties of melanin is lost, resulting in an altered redox phenotype. We propose that such an alteration o...

journal_title：Melanoma research

authors： Sarangarajan R,Apte SP

更新日期：2006-02-01 00:00:00

abstract：:Recently, we reported on the associations of seven single nucleotide polymorphisms (SNPs) in the promoter region of MMP1 gene with susceptibility to cutaneous melanoma (CM). Considering the reported correlation between MMP1 expression and melanoma progression, we hypothesized that these promoter SNPs might affect CM p...

journal_title：Melanoma research

authors： Liu H,Wei Q,Gershenwald JE,Prieto VG,Lee JE,Duvic M,Grimm EA,Wang LE

更新日期：2012-04-01 00:00:00

abstract：:The proto-oncogene c-Kit encodes a membrane receptor protein with intrinsic tyrosine kinase activity. Activation of c-Kit induces cell proliferation, differentiation or migration among different cell types. The present study provides evidence that c-Kit plays an important role in the cell differentiation rather than i...

journal_title：Melanoma research

authors： Luo D,Chen H,Searles G,Jimbow K

更新日期：1995-10-01 00:00:00

abstract：:Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

journal_title：Melanoma research

authors： O'Leary DP,Byrnes KG,Power DG,Redmond HP

更新日期：2015-02-01 00:00:00

abstract：:Recently, TROG 02.01 results showed that in stage III melanoma patients with nodal metastasis, adjuvant radiation to lymph node basin after nodal dissection improves lymph node field relapse without an overall survival (OS) benefit. However, this trial was neither designed nor powered to detect an OS difference. In th...

journal_title：Melanoma research

authors： Danish HH,Patel KR,Switchenko JM,Gillespie TW,Jhaveri J,Chowdhary M,Abugideiri M,Delman KA,Lawson DH,Khan MK

更新日期：2016-12-01 00:00:00

abstract：:Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masqueradi...

journal_title：Melanoma research

authors： Moshe M,Levi A,Ad-El D,Ben-Amitai D,Mimouni D,Didkovsky E,Feinmesser M,Lapidoth M

更新日期：2018-08-01 00:00:00

abstract：:Dermoscopy is a non-invasive technique that can be utilized for the clinical diagnosis of pigmented lesions. The aim of this study was to assess the utilization and beliefs about the usefulness of dermoscopy in the evaluation of pigmented lesions by physicians in dermatology residency programmes, and to determine the ...

journal_title：Melanoma research

authors： Nehal KS,Oliveria SA,Marghoob AA,Christos PJ,Dusza SW,Tromberg JS,Halpern AC

更新日期：2002-12-01 00:00:00

abstract：:Violacein is the main pigment produced by Chromobacterium violaceum, a saprophytic gram-negative bacillus. Violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. The purpose of this pilot study was to investigate the in vitro activity of violacein in hum...

journal_title：Melanoma research

authors： Saraiva VS,Marshall JC,Cools-Lartigue J,Burnier MN Jr

更新日期：2004-10-01 00:00:00

abstract：:Results obtained using a computerized image analysis system as an aid to clinical diagnosis of melanoma are reported. The system comprises a colour television camera connected through a digitizing board to a 386 personal computer. By means of original algorithms able to measure the shape, the colours and texture of a ...

journal_title：Melanoma research

authors： Cascinelli N,Ferrario M,Bufalino R,Zurrida S,Galimberti V,Mascheroni L,Bartoli C,Clemente C

更新日期：1992-09-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

journal_title：Melanoma research

authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

更新日期：2016-06-01 00:00:00

abstract：:M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the relationship with tumor progression and known prognostic parameters. Fifty-...

journal_title：Melanoma research

authors： Tas F,Karabulut S,Serilmez M,Yildiz I,Sen F,Ciftci R,Duranyildiz D

更新日期：2013-10-01 00:00:00

abstract：:In this study we compared the strength of the association of constitutional factors and sun exposure with cutaneous malignant melanoma (CMM) and basal cell carcinoma (BCC). We analysed 260 incident cases of CMM, 425 incident cases of BCC and two sets of population controls from previous case-control studies conducted ...

journal_title：Melanoma research

authors： Rosso S,Zanetti R,Pippione M,Sancho-Garnier H

更新日期：1998-12-01 00:00:00

abstract：:Prognostic blood biomarkers for patients with uveal melanoma have not been identified. Tumor monosomy-3 is strongly associated with the development of metastatic disease. Tumor expression of human leukocyte antigen class I molecules and insulin-like growth factor (IGF)-1 receptor has also been associated with the deve...

journal_title：Melanoma research

authors： Triozzi PL,Elson P,Aldrich W,Achberger S,Tubbs R,Biscotti CV,Singh AD

更新日期：2013-02-01 00:00:00

abstract：:We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...

journal_title：Melanoma research

authors： Ros-Bullón MR,Sánchez-Pedreño P,Martínez-Liarte JH

更新日期：1998-06-01 00:00:00

abstract：:Between 1983 and 1992, 21 patients with extremity stage IIIA or IIIAB melanoma underwent hyperthermic isolation limb perfusion (HILP) with cisplatin in dosages varying from 26 to 237 mg/m2 as part of a pharmacokinetics and maximum-tolerated dose study. Extremity temperatures were up to 40 degrees C and the pH was cont...

journal_title：Melanoma research

authors： Fletcher WS,Pommier R,Small K

更新日期：1994-03-01 00:00:00

abstract：:Downstream of Ras, the serine/threonine kinase B-raf has been reported to be mutated, amongst other carcinomas, in a substantial subset of primary melanomas, with a preponderance of mutations within the kinase domain, including the activating V599E and V599K transitions. We investigated a representative series of 54 r...

journal_title：Melanoma research

authors： Kirschner M,Helmke B,Starz H,Benner A,Thome M,Deichmann M

更新日期：2005-10-01 00:00:00

abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

journal_title：Melanoma research

authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

更新日期：2020-04-01 00:00:00

abstract：:Radiotherapy after lymph node dissection is recommended in high-risk melanoma cases. The aim of this study is to assess whether intensity-modulated radiotherapy (IMRT) offers advantages over three-dimensional conformal radiotherapy (3DCRT) in the groin nodal basin. Fifteen consecutively treated patients (5 3DCRT and 1...

journal_title：Melanoma research

authors： Adams G,Foote M,Brown S,Burmeister B

更新日期：2017-02-01 00:00:00

abstract：:Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We ...

journal_title：Melanoma research

authors： Caini S,Gandini S,Botta F,Tagliabue E,Raimondi S,Nagore E,Zanna I,Maisonneuve P,Newton-Bishop J,Polsky D,Lazovich D,Kumar R,Kanetsky PA,Hoiom V,Ghiorzo P,Landi MT,Ribas G,Menin C,Stratigos AJ,Palmieri G,Guida G,

更新日期：2020-10-01 00:00:00

abstract：:Superficial spreading melanoma (SSM) is the most common type of melanoma. Large, population-based studies analyzing the incidence and survival of SSM are limited. This retrospective study was designed to evaluate demographic factors influencing the incidence and survival of SSM using a national population-based databa...

journal_title：Melanoma research

authors： Singh P,Kim HJ,Schwartz RA

更新日期：2016-08-01 00:00:00

abstract：:Loss of expression of E-cadherin, the major cell-cell adhesion receptor on keratinocytes, has been linked to tumour progression in various carcinomas. As E-cadherin has been reported to be expressed in cultured human melanocytes, we questioned whether loss of E-cadherin expression may also be related to melanocytic tu...

journal_title：Melanoma research

authors： Danen EH,de Vries TJ,Morandini R,Ghanem GG,Ruiter DJ,van Muijen GN

更新日期：1996-04-01 00:00:00

abstract：:The objective of this study was to describe the risk factor profile of skin cancer screening participants and to determine whether there is an association between the number of skin cancer/melanoma risk factors and the likelihood of diagnosis of a malignant melanoma. Seventy skin cancer screening clinics were held by ...

journal_title：Melanoma research

authors： Williams HA,Fritschi L,Beauchamp C,Katris P

更新日期：2006-08-01 00:00:00

abstract：:Regional lymph nodes are affected frequently by melanoma metastasis. Its microenvironment may be associated with tumor progression. We investigated sentinel nodes with and without tumor and negative nodes surrounding positive nodes, looking for patterns related to tumor immune interaction and lymphovascular progressio...

journal_title：Melanoma research

authors： Alessi C,Scapulatempo Neto C,Viana CR,Vazquez VL

更新日期：2017-12-01 00:00:00

abstract：:Among patients with advanced melanoma, the development of autoimmune phenomena or of hypothyroidism during therapy has been associated with a favourable outcome. The objective of this study was to determine the prevalence of autoimmunity and of hypothyroidism in the melanoma population as a whole and to determine if t...

journal_title：Melanoma research

authors： Ellerhorst JA,Cooksley CD,Grimm EA

更新日期：2001-12-01 00:00:00

abstract：:We examined the incidence of primary invasive melanoma in the municipality of Reggio Emilia, northern Italy, in the period from 1986 to 1997. We identified 169 cases, five of which were intraocular. After adjustment for confounders, the risk of having a thick melanoma (Breslow > or = 1 mm) did not decrease over time, ...

journal_title：Melanoma research

authors： Vinceti M,Bergomi M,Borciani N,Serra L,Vivoli G

更新日期：1999-02-01 00:00:00

abstract：:Metabolic imaging with F-18 fluorodeoxy-D-glucose positron emission tomography is one of the most sensitive and non-invasive techniques, and has proved useful in melanoma. We designed, in 2004, at the Institute Gustave Roussy, a prospective study to determine the value of F-18 fluorodeoxy-D-glucose positron emission t...

journal_title：Melanoma research

authors： Maubec E,Lumbroso J,Masson F,Suciu V,Kolb F,Mamelle G,Cavalcanti A,Boitier F,Spatz A,Aupérin A,Leboulleux S,Avril MF

更新日期：2007-06-01 00:00:00

abstract：:Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...

journal_title：Melanoma research

authors： Berrocal A,Arance A,Lopez Martin JA,Soriano V,Muñoz E,Alonso L,Espinosa E,Lopez Criado P,Valdivia J,Martin Algarra S,Spanish Melanoma Group.

更新日期：2014-12-01 00:00:00