Her2/neu is not a commonly expressed therapeutic target in melanoma -- a large cohort tissue microarray study.

abstract：:Pigmented basal cell carcinoma (PBCC) is a tumour with distinct clinical features which occasionally may be difficult to differentiate from malignant melanoma (MM). The purpose of this study was to re-examine the epiluminescence microscopy (ELM) criteria for PBCC and to determine their statistical significance in the ...

journal_title：Melanoma research

authors： Püspök-Schwarz M,Steiner A,Binder M,Partsch B,Wolff K,Pehamberger H

更新日期：1997-08-01 00:00:00

abstract：:We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

journal_title：Melanoma research

authors： Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

更新日期：2004-12-01 00:00:00

abstract：:This randomized phase II trial was performed to define the activity and toxicity of the combination of dacarbazine (DTIC), carmustine (BCNU), cisplatin (DDP) and tamoxifen (DBDT regimen) versus DTIC alone in patients with metastatic melanoma. Sixty patients with metastatic melanoma were randomly assigned to receive BC...

journal_title：Melanoma research

authors： Chiarion Sileni V,Nortilli R,Aversa SM,Paccagnella A,Medici M,Corti L,Favaretto AG,Cetto GL,Monfardini S

更新日期：2001-04-01 00:00:00

abstract：:During the process of melanogenesis free radicals are generated. The aim of this study was to investigate the effects of melanogenesis in B16 melanoma on lipid peroxidation and antioxidant capacity in selected tissues of black C57BL/6J mice. The study was conducted on 24 mice: 12 healthy controls and 12 with a transpl...

journal_title：Melanoma research

authors： Woźniak A,Woźniak B,Drewa G,Drewa T

更新日期：2003-02-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely...

journal_title：Melanoma research

authors： Danish H,Ferris MJ,Balagamwala E,Switchenko JM,Patel KR,Choudhary M,Craven C,Mendoza P,Suh J,Bergstrom C,Grossniklaus HE,M Aaberg T Sr,Singh A,Crocker IR,Khan MK

更新日期：2018-04-01 00:00:00

abstract：:The aim of our study was to evaluate the clinical and morphological features of primary malignant melanomas of the urinary bladder. We obtained information on five such cases from three different institutions. These were three men and two women between 52 and 76 years of age. Three tumors presented with hematuria, one...

journal_title：Melanoma research

authors： Karabulut YY,Erdogan S,Sayar H,Ergen A,Ertoy Baydar D

更新日期：2016-12-01 00:00:00

abstract：:The CD10 antigen is a neutral endopeptidase expressed by a variety of mesenchymal tumours (haemopoietic or not), including a subset of malignant melanomas. We investigated the expression of CD10 in formalin-fixed, paraffin-embedded tissue specimens of 72 cutaneous melanomas (28 primary, 26 metastatic to the skin and 1...

journal_title：Melanoma research

authors： Kanitakis J,Narvaez D,Claudy A

更新日期：2002-06-01 00:00:00

abstract：:Seasonal variation in melanoma diagnoses has been observed in numerous studies that used calendar time indicators. Depending on the latitude (and altitude) of the study region, the magnitude of seasonal and year-to-year variation of ultraviolet radiation (UVR) is neglected in these studies. An alternative approach com...

journal_title：Melanoma research

authors： Keller AK,Uter W,Pfahlberg AB,Radespiel-Tröger M,Mayer I,Gefeller O

更新日期：2015-12-01 00:00:00

abstract：:The treatment of cancer during pregnancy presents a unique challenge. Optimal treatments are often altered or even delayed to protect fetal growth and organogenesis. The landscape of cancer treatment has shifted dramatically over the past several years and treatment with checkpoint inhibitors, including anti-PD1 and a...

journal_title：Melanoma research

authors： Bucheit AD,Hardy JT,Szender JB,Glitza Oliva IC

更新日期：2020-08-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were d...

journal_title：Melanoma research

authors： Brütting J,Bergmann M,Garzarolli M,Rauschenberg R,Weber C,Berking C,Tilgen W,Schadendorf D,Meier F,NVKH supporting group.

更新日期：2019-04-01 00:00:00

abstract：:Our previous in vivo studies indicated that a phenolic thioether amine (PTEA), 4-S-cysteaminylphenol (CAP), selectively disintegrates melanocytes of black hair and skin, and inhibits the growth of murine and human malignant melanomas. To elucidate the mechanism of the in vivo melanocytotoxicity and anti-melanoma effec...

journal_title：Melanoma research

authors： Yamada K,Jimbow K

更新日期：1992-11-01 00:00:00

abstract：:Conditional survival in patients with localized primary cutaneous malignant melanoma (CMM) is well described. However, conditional recurrence-free survival (RFS) has not been investigated before. The aim of this study was to determine conditional RFS and test for time dependency in prognostic factors in patients with ...

journal_title：Melanoma research

authors： Lyth J

更新日期：2018-12-01 00:00:00

abstract：:In patients with metastatic cancer, gut microbiome composition differs between responder and non-responders to immune checkpoint inhibitors. However, there is little consensus on the microbiome taxa associated with response or lack of response. Additionally, recognized confounders of gut microbiome composition have ge...

journal_title：Melanoma research

authors： Wind TT,Gacesa R,Vich Vila A,de Haan JJ,Jalving M,Weersma RK,Hospers GAP

更新日期：2020-06-01 00:00:00

abstract：:Melanoma patients frequently have elevated serum levels of interleukin-6 (IL-6), which is correlated with a poor prognosis. IL-6 activates STAT3 phosphorylation, inducing the transcription of genes that regulate tumor cell proliferation and antiapoptosis. In addition, recent evidence suggests that IL-6 induces the epi...

journal_title：Melanoma research

authors： Na YR,Lee JS,Lee SJ,Seok SH

更新日期：2013-12-01 00:00:00

abstract：:Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on thi...

journal_title：Melanoma research

authors： de Souza Neto FP,Bernardes SS,Marinello PC,Melo GP,Luiz RC,Cecchini R,Cecchini AL

更新日期：2017-12-01 00:00:00

abstract：:Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM...

journal_title：Melanoma research

authors： Sorich MJ,Rowland A,Hopkins AM

更新日期：2020-06-01 00:00:00

abstract：:Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...

journal_title：Melanoma research

authors： Avril MF,Chompret A,Verne-Fourment L,Terrier-Lacombe MJ,Spatz A,Fizazi K,Bressac-de Paillerets B,Demenais F,Théodore C

更新日期：2001-04-01 00:00:00

abstract：:The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition i...

journal_title：Melanoma research

authors： Sarojini S,Pecora A,Milinovikj N,Barbiere J,Gupta S,Hussain ZM,Tuna M,Jiang J,Adrianzen L,Jun J,Catello L,Sanchez D,Agarwal N,Jeong S,Jin Y,Remache Y,Goy A,Ndlovu A,Ingenito A,Suh KS

更新日期：2015-10-01 00:00:00

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:Cerebral metastases from melanoma are correlated with a poor prognosis. Temozolomide is an oral alkylating agent that can cross the blood-brain barrier and in phase II and III trials, patients with advanced metastatic melanoma achieved overall response rates of 13 to 21%. The present study evaluated the efficacy and t...

journal_title：Melanoma research

authors： Bafaloukos D,Tsoutsos D,Fountzilas G,Linardou H,Christodoulou C,Kalofonos HP,Briassoulis E,Panagiotou P,Hatzichristou H,Gogas H

更新日期：2004-08-01 00:00:00

abstract：:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the l...

journal_title：Melanoma research

authors： Kolandjian NA,Patel SP,Papadopoulos NE,Bedikian AY

更新日期：2011-04-01 00:00:00

abstract：:Results obtained using a computerized image analysis system as an aid to clinical diagnosis of melanoma are reported. The system comprises a colour television camera connected through a digitizing board to a 386 personal computer. By means of original algorithms able to measure the shape, the colours and texture of a ...

journal_title：Melanoma research

authors： Cascinelli N,Ferrario M,Bufalino R,Zurrida S,Galimberti V,Mascheroni L,Bartoli C,Clemente C

更新日期：1992-09-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

journal_title：Melanoma research

authors： Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

更新日期：1997-12-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:MAGE proteins have been identified as potential specific targets for cancer vaccination. Although MAGE-6 and MAGE-12 were originally identified in malignant melanoma there are no studies reporting the frequency of expression of these antigens in this malignancy. These are of relevance particularly for MAGE-6 as recent...

journal_title：Melanoma research

authors： Gibbs P,Hutchins AM,Dorian KT,Vaughan HA,Davis ID,Silvapulle M,Cebon JS

更新日期：2000-06-01 00:00:00

abstract：:Patients with melanoma may experience a variety of different vision symptoms, in part associated with melanoma-associated retinopathy. For several melanoma patients with or without melanoma-associated retinopathy, colour vision deficiencies, especially involving the tritan system, have been reported. The frequency of ...

journal_title：Melanoma research

authors： Pföhler C,Tschöp S,König J,Rass K,Tilgen W

更新日期：2006-10-01 00:00:00

abstract：:Although pelvic computed tomography (CT) scans are frequently performed as a part of routine surveillance, the evidence for or against the routine use of these scans in patients with primary melanoma in the head and neck is weak. We conducted a retrospective study to evaluate the value of pelvic CT scans as routine su...

journal_title：Melanoma research

authors： Alvarado GC,Papadopoulos NE,Hwu WJ,Bedikian AY,Homsi J,Myers JN,Bronstein Y,Bassett RL,Hwu P,Kim KB

更新日期：2011-04-01 00:00:00