Rising melanoma incidence in an Italian community from 1986 to 1997.

abstract：:M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the relationship with tumor progression and known prognostic parameters. Fifty-...

journal_title：Melanoma research

authors： Tas F,Karabulut S,Serilmez M,Yildiz I,Sen F,Ciftci R,Duranyildiz D

更新日期：2013-10-01 00:00:00

abstract：:Interleukin-24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7) is a unique cytokine-tumor suppressor that displays ubiquitous antitumor properties and tumor-specific killing activity. Oncostatin M (OSM) is the most active IL-6-type cytokine and inhibits the proliferation of various solid tumor cell lines. M...

journal_title：Melanoma research

authors： Xu Y,Zhang F,Qin L,Miao J,Sheng W,Xie Y,Xu X,Yang J,Qian H

更新日期：2014-02-01 00:00:00

abstract：:This study addressed the impact of exposure to ultraviolet radiation on the risk of cutaneous malignant melanoma (CMM), as well as the behavioral components at stake in its occurrence. We performed a one-to-one unmatched case-control study among subjects aged 20 years or more with naturally non-pigmented skin in Germa...

journal_title：Melanoma research

authors： Autier P,Doré JF,Lejeune F,Koelmel KF,Geffeler O,Hille P,Cesarini JP,Liénard D,Liabeuf A,Joarlette M

更新日期：1994-04-01 00:00:00

abstract：:The liver is the predominant site of metastases in the majority of patients with uveal melanoma, suggesting the evaluation of regional treatment approaches. Here we report our experience with transarterial chemoembolization (TACE) in uveal melanoma patients with pretreated liver metastases. Twenty-five patients were t...

journal_title：Melanoma research

authors： Schuster R,Lindner M,Wacker F,Krössin M,Bechrakis N,Foerster MH,Thiel E,Keilholz U,Schmittel A

更新日期：2010-06-01 00:00:00

abstract：:To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were...

journal_title：Melanoma research

authors： Bohelay G,Battistella M,Pagès C,de Margerie-Mellon C,Basset-Seguin N,Viguier M,Kerob D,Madjlessi N,Baccard M,Archimbaud A,Comte C,Mourah S,Porcher R,Bagot M,Janin A,De Kerviler E,Lebbé C

更新日期：2015-12-01 00:00:00

abstract：:Ginsenoside Rg3 is an effective chemical component extracted from the red Panix. The experiment demonstrated that it might effectively inhibit proliferation and metastasis of tumor cells. The exact molecular mechanism of Rg3 remains unclear so far. To further explore the antitumor function of Rg3, we investigated the ...

journal_title：Melanoma research

authors： Chen J,Peng H,Ou-Yang X,He X

更新日期：2008-10-01 00:00:00

abstract：:Melanogenesis appears to be a unique target to develop anti-tumour agents specific for malignant melanoma. Among the anti-melanoma compounds that we have examined, 4-S-cysteaminylphenol (4-S-CAP), a phenolic amine, was found to have the most promising anti-melanoma effects. To further improve the efficacy as anti-mela...

journal_title：Melanoma research

authors： Yukitake J,Otake H,Inoue S,Wakamatsu K,Ito S

更新日期：2004-04-01 00:00:00

abstract：:Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which are applied directly to the tumour. The pulses facilitate delivery of drug through the plasma membrane. Enhanced delivery is rest...

journal_title：Melanoma research

authors： Jaroszeski MJ,Gilbert R,Perrott R,Heller R

更新日期：1996-12-01 00:00:00

abstract：:Accumulating evidence has suggested that the XRCC1 Arg399Gln and Arg194Trp polymorphisms might be related to cutaneous melanoma susceptibility. However, epidemiologic findings have been inconsistent. We have assessed reported studies by meta-analysis to perform a more precise estimation of the association between the ...

journal_title：Melanoma research

authors： Jiang H,Xu W,Zhang F,Wei L,Wang Y,Wang Y,Liu C

更新日期：2016-06-01 00:00:00

abstract：:The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

journal_title：Melanoma research

authors： Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

更新日期：1997-12-01 00:00:00

abstract：:To examine the distribution of occult micrometastases that could be potential sources of recurrence, complete maps of microscopic and submicroscopic metastases in entire inguinal lymph node basins were generated in 13 melanoma patients who had undergone elective or therapeutic lymphadenectomy. Occult micrometastases w...

journal_title：Melanoma research

authors： Hatta N,Fujimoto A,Takehara K,Takata M

更新日期：1999-08-01 00:00:00

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:In order to investigate the effects of in vivo treatment with interferon-alpha (IFN-alpha) on melanoma antigens, a clinical EORTC trial (No. 18852) was accompanied by an immunohistological study. Twenty patients with melanoma metastases of skin and soft tissues, eventually also of the lung, who were treated with syste...

journal_title：Melanoma research

authors： von Stamm U,Bröcker EB,von Depka Prondzinski M,Ruiter DJ,Rümke P,Broding C,Carrel S,Lejeune FJ

更新日期：1993-06-01 00:00:00

abstract：:The aim of this study was to evaluate S100B in bone marrow (BM) plasma from malignant melanoma patients. BM aspirates and peripheral blood (PB) plasma from 56 patients and BM aspirates from 29 healthy volunteers were collected. S100B was measured using an immune radiometric assay, which is a two-site sandwich assay ba...

journal_title：Melanoma research

authors： Faye RS,Paus E,Maelandsmo GM,Berner A,Høifødt HK,Fodstad Ø,Aamdal S

更新日期：2008-04-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic m...

journal_title：Melanoma research

authors： Rambhia PH,Honda K,Arbesman J

更新日期：2018-10-01 00:00:00

abstract：:Ipilimumab, a fully human, recombinant, monoclonal antibody to cytotoxic T-lymphocyte antigen 4 improves overall survival (OS) in previously treated and untreated metastatic melanoma. This retrospective analysis reports data gathered by a questionnaire on the demographics, outcomes, and toxicity of ipilimumab administ...

journal_title：Melanoma research

authors： Berrocal A,Arance A,Lopez Martin JA,Soriano V,Muñoz E,Alonso L,Espinosa E,Lopez Criado P,Valdivia J,Martin Algarra S,Spanish Melanoma Group.

更新日期：2014-12-01 00:00:00

abstract：:Our previous in vivo studies indicated that a phenolic thioether amine (PTEA), 4-S-cysteaminylphenol (CAP), selectively disintegrates melanocytes of black hair and skin, and inhibits the growth of murine and human malignant melanomas. To elucidate the mechanism of the in vivo melanocytotoxicity and anti-melanoma effec...

journal_title：Melanoma research

authors： Yamada K,Jimbow K

更新日期：1992-11-01 00:00:00

abstract：:A large body of evidence in the scientific literature suggests that the numbers of common and atypical nevi are strong, independent risk factors for the occurrence of cutaneous malignant melanoma. Furthermore, some studies recently found an association between high nevus counts and an improved melanoma prognosis. The ...

journal_title：Melanoma research

authors： De Giorgi V,Scarfì F,Gori A,Maida P,Trane L,Silvestri F,Portelli F,Massi D,Covarelli P,Gandini S

更新日期：2020-04-01 00:00:00

abstract：:Results obtained using a computerized image analysis system as an aid to clinical diagnosis of melanoma are reported. The system comprises a colour television camera connected through a digitizing board to a 386 personal computer. By means of original algorithms able to measure the shape, the colours and texture of a ...

journal_title：Melanoma research

authors： Cascinelli N,Ferrario M,Bufalino R,Zurrida S,Galimberti V,Mascheroni L,Bartoli C,Clemente C

更新日期：1992-09-01 00:00:00

abstract：:Staging of melanoma patients by means of whole body functional imaging in a single evaluation session using positron emission tomography (PET) with fluorine-18- labelled deoxy-d-glucose (FDG) as a metabolic tracer has created much interest over the last decade. After enthusiastic pilot studies, more attention has been...

journal_title：Melanoma research

authors： Stas M,Stroobants S,Dupont P,Gysen M,Hoe LV,Garmyn M,Mortelmans L,Wever ID

更新日期：2002-10-01 00:00:00

abstract：:Treatment of patients with metastatic melanoma with either dacarbazine (DTIC) or interferon-alpha (IFNalpha) as single drugs, or in combination, results in a response rate of approximately 15-20%. This study evaluated the activity and toxicity following treatment with a combination of DTIC, IFNalpha2b and verapamil (V...

journal_title：Melanoma research

authors： Andersson R,Ake Hofer P,Riklund-Ahlström K,Henriksson R

更新日期：2003-02-01 00:00:00

abstract：:Despite the general advances in the chemotherapy of malignancies, progress comes slow in the management of patients with disseminated melanoma. Unreflected enthusiasm and frustrated scepticism are the scylla and charybdis between which the physician tries to choose the right way. ...

journal_title：Melanoma research

authors： Kleeberg UR

更新日期：1997-08-01 00:00:00

abstract：:Putative tumour suppressor genes CDKN2A and CDKN2B (on chromosome 9p21) and CDKN2A-interacting cell growth regulatory genes CDK4 and Id-1 have been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). Mutation analysis of these candidate genes was performed in MM families from southern Italy wit...

journal_title：Melanoma research

authors： Casula M,Ascierto PA,Cossu A,Sini MC,Tore S,Colombino M,Satta MP,Manca A,Rozzo C,Satriano SM,Castello G,Lissia A,Tanda F,Palmieri G

更新日期：2003-12-01 00:00:00

abstract：:In this study we evaluated the overexpression status of HER-2 and its prognostic significance on survival in patients with thick cutaneous malignant melanoma. The immuno-alkaline phosphatase antigen detection technique was applied to archival diagnostic material from 51 patients with primary lesions measuring >or= 10 ...

journal_title：Melanoma research

authors： Eliopoulos P,Mohammed MQ,Henry K,Retsas S

更新日期：2002-04-01 00:00:00

abstract：:The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell lines was examined by Cell T...

journal_title：Melanoma research

authors： Shellman YG,Ribble D,Miller L,Gendall J,Vanbuskirk K,Kelly D,Norris DA,Dellavalle RP

更新日期：2005-04-01 00:00:00

abstract：:Isolated limb perfusion (ILP) with melphalan is used to treat recurrent melanoma. This study aimed to develop a microdialysis technique for melphalan tissue concentration measurement during ILP. The effects of melphalan concentration (50-600 microg/ml), microdIalysis flow rate (0.55-17.5 microl/min), probe length (5-5...

journal_title：Melanoma research

authors： Wu ZY,Smithers BM,Anderson C,Roberts MS

更新日期：2000-02-01 00:00:00

abstract：:The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...

journal_title：Melanoma research

authors： Zukauskaite R,Schmidt H,Asmussen JT,Hansen O,Bastholt L

更新日期：2013-02-01 00:00:00

abstract：:The management of melanoma brain metastases (MBM) includes different therapeutic modalities, such as surgery, radiotherapy and chemotherapy. Despite the choice of treatments, survival remains poor, exceeding 1 year only in patients with solitary metastases and absence of extracranial disease. A total of 115 consecutiv...

journal_title：Melanoma research

authors： Vecchio S,Spagnolo F,Merlo DF,Signori A,Acquati M,Pronzato P,Queirolo P

更新日期：2014-02-01 00:00:00

abstract：:Accurate staging of patients with primary cutaneous melanoma includes assessment of regional lymph nodes for the presence of micrometastatic disease. Sentinel lymph node biopsy is highly accurate but is an invasive surgical procedure with a 5-10% complication rate, and requires labour-intensive and expensive histologi...

journal_title：Melanoma research

authors： Lean CL,Bourne R,Thompson JF,Scolyer RA,Stretch J,Li LX,Russell P,Mountford C

更新日期：2003-06-01 00:00:00

abstract：:The goal of this study was to determine the effect of oral melatonin in divided doses on plasma melatonin levels in patients with metastatic melanoma. Hourly blood samples were obtained from five patients for 24 h prior to melatonin administration and for 24 h during oral administration of melatonin, 50 mg every 4 h. ...

journal_title：Melanoma research

authors： Kane MA,Johnson A,Nash AE,Boose D,Mathai G,Balmer C,Yohn JJ,Robinson WA

更新日期：1994-02-01 00:00:00