Autoimmunity and hypothyroidism in patients with uveal melanoma.

abstract：:Between 6 and 14% of malignant melanomas have been reported to occur in a familial pattern. In this study 785 melanoma patients from the Victorian Melanoma Service and the private practice of a dermatologist were assessed for the total number of melanocytic naevi, the number of dysplastic naevi and other clinical char...

journal_title：Melanoma research

authors： Ang CG,Kelly JW,Fritschi L,Dowling JP

更新日期：1998-10-01 00:00:00

abstract：:Desmoplastic melanoma (DM) due to its rare and locally aggressive nature, can be difficult to study and to treat effectively. Whether the optimal treatment approach for these tumors should include adjuvant radiation has been unclear in the literature. In this retrospective study of the National Cancer Database, 2390 p...

journal_title：Melanoma research

authors： Abbott JL,Qureshi MM,Truong MT,Sahni D

更新日期：2019-08-01 00:00:00

abstract：:Levels of eumelanin (EM) and pheomelanin (PM) of uveal melanoma cells have not been measured and compared with those of normal uveal melanocytes. EM and PM amounts in four immortal human uveal melanoma cell lines were measured by chemical degradation and microanalytical high-performance liquid chromatography and compa...

journal_title：Melanoma research

authors： Hu DN,Wakamatsu K,Ito S,McCormick SA

更新日期：2009-04-01 00:00:00

abstract：:We studied the levels of serum copper and zinc as possible diagnostic factors or markers for the early detection of patients with melanoma. Levels were determined in 35 melanoma patients at various clinical stages and in 39 healthy persons. Measurements were performed by atomic absorption spectroscopy using 5100-PC-Pe...

journal_title：Melanoma research

authors： Ros-Bullón MR,Sánchez-Pedreño P,Martínez-Liarte JH

更新日期：1998-06-01 00:00:00

abstract：:Melanoma patients frequently have elevated serum levels of interleukin-6 (IL-6), which is correlated with a poor prognosis. IL-6 activates STAT3 phosphorylation, inducing the transcription of genes that regulate tumor cell proliferation and antiapoptosis. In addition, recent evidence suggests that IL-6 induces the epi...

journal_title：Melanoma research

authors： Na YR,Lee JS,Lee SJ,Seok SH

更新日期：2013-12-01 00:00:00

abstract：:Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple ...

journal_title：Melanoma research

authors： Avril MF,Chompret A,Verne-Fourment L,Terrier-Lacombe MJ,Spatz A,Fizazi K,Bressac-de Paillerets B,Demenais F,Théodore C

更新日期：2001-04-01 00:00:00

abstract：:Recently, TROG 02.01 results showed that in stage III melanoma patients with nodal metastasis, adjuvant radiation to lymph node basin after nodal dissection improves lymph node field relapse without an overall survival (OS) benefit. However, this trial was neither designed nor powered to detect an OS difference. In th...

journal_title：Melanoma research

authors： Danish HH,Patel KR,Switchenko JM,Gillespie TW,Jhaveri J,Chowdhary M,Abugideiri M,Delman KA,Lawson DH,Khan MK

更新日期：2016-12-01 00:00:00

abstract：:Tyrosinase is the key enzyme in melanin biosynthesis in pigmented cells. We transfected 9L rat glioma cells with human tyrosinase cDNA that had been cloned in a high expression vector. Stable transfectants were selected by their resistance to the antibiotic G418. More than a dozen G418-resistant clones were isolated a...

journal_title：Melanoma research

authors： Singh MV,Jimbow K

更新日期：1998-12-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00

abstract：:This study examines whether 6-thioguanine resistant T cells (mutant) from metastatic melanoma patients are enriched for melanoma-associated T cells compared to T cells obtained analogously without thioguanine selection (wild-type). Melanoma-associated antigen pentamer staining was performed on 5 tumour and 9 periphera...

journal_title：Melanoma research

authors： Zuleger CL,Newton MA,Ma X,Ong IM,Pei Q,Albertini MR

更新日期：2020-02-01 00:00:00

abstract：:We describe a rare case of transplacental-transmitted maternal melanoma to the placenta and foetus during the second pregnancy of a 28-year-old woman. She was aware of a greyish-brown nodular lesion on the right gluteus during her first pregnancy. On histological examination, this lesion resulted to be an amelanocitic...

journal_title：Melanoma research

authors： Valenzano Menada M,Moioli M,Garaventa A,Nozza P,Foppiano M,Trimarchi N,Fulcheri E

更新日期：2010-12-01 00:00:00

abstract：:The growth rate (GR) of melanomas is not uniform. A fast-growing subtype has been identified and seems to have a role in the stabilization of the mortality rates because of melanoma. To examine features associated with fast-growing melanomas (FGMs) and to determine the relationship between the GR and well-recognized p...

journal_title：Melanoma research

authors： Martorell-Calatayud A,Nagore E,Botella-Estrada R,Scherer D,Requena C,Serra-Guillén C,Llombart B,Sanmartin O,Kumar R,Guillén C

更新日期：2011-04-01 00:00:00

abstract：:Regression of metastatic melanoma is a rare event, and review of the literature reveals a total of 76 reported cases since 1866. The proposed mechanisms include immunologic, endocrine, inflammatory and metastatic tumour nutritional factors. We conclude from this review that although the precise mechanisms remain unkno...

journal_title：Melanoma research

authors： Kalialis LV,Drzewiecki KT,Klyver H

更新日期：2009-10-01 00:00:00

abstract：:Immune checkpoint inhibitors targeting the programmed cell death (PD)-1 receptor have dramatically changed the landscape of metastatic melanoma treatment. Nevertheless, these immuno-modulatory agents have associated side effects, including dermatologic manifestations. To this end, we report a patient with metastatic m...

journal_title：Melanoma research

authors： Rambhia PH,Honda K,Arbesman J

更新日期：2018-10-01 00:00:00

abstract：:Electroporation therapy (EPT) is a novel treatment modality that uses brief, high-intensity, pulsed electrical currents to enhance the uptake of chemotherapeutic agents, vaccines and genes into cells. This technique is potentially useful for patients with secondary and, possibly, some primary tumours. Nineteen patient...

journal_title：Melanoma research

authors： Byrne CM,Thompson JF,Johnston H,Hersey P,Quinn MJ,Michael Hughes T,McCarthy WH

更新日期：2005-02-01 00:00:00

abstract：:Recreational exposure to the sun may not explain fully current trends in melanoma incidence. The hypothesis was examined whether carcinogens in water play a role in the development of cutaneous melanoma. In a case-control study, 128 melanoma patients and 168 patients with other types of malignancy completed a detailed...

journal_title：Melanoma research

authors： Nelemans PJ,Rampen FH,Groenendal H,Kiemeney LA,Ruiter DJ,Verbeek AL

更新日期：1994-10-01 00:00:00

abstract：:The presence of substantial amounts of GM3 ganglioside on human melanomas and other tumours, together with its peculiar biological properties, makes this glycolipid a unique target for cancer immunotherapy. B16 mouse melanoma expresses GM3 and constitutes an appropriate model for the development of novel GM3-based vac...

journal_title：Melanoma research

authors： Carr A,Mazorra Z,Alonso DF,Mesa C,Valiente O,Gomez DE,Perez R,Fernandez LE

更新日期：2001-06-01 00:00:00

abstract：:Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We ...

journal_title：Melanoma research

authors： Caini S,Gandini S,Botta F,Tagliabue E,Raimondi S,Nagore E,Zanna I,Maisonneuve P,Newton-Bishop J,Polsky D,Lazovich D,Kumar R,Kanetsky PA,Hoiom V,Ghiorzo P,Landi MT,Ribas G,Menin C,Stratigos AJ,Palmieri G,Guida G,

更新日期：2020-10-01 00:00:00

abstract：:Conditional survival in patients with localized primary cutaneous malignant melanoma (CMM) is well described. However, conditional recurrence-free survival (RFS) has not been investigated before. The aim of this study was to determine conditional RFS and test for time dependency in prognostic factors in patients with ...

journal_title：Melanoma research

authors： Lyth J

更新日期：2018-12-01 00:00:00

abstract：:The concept of 'vasculogenic mimicry' (VM) was introduced to describe the unique ability of highly invasive tumor cells to form capillary-like structures (CLS) and matrix-rich patterned network in three-dimensional culture that mimic embryonic vasculogenic network. Recently, we have shown that CLS formation requires a...

journal_title：Melanoma research

authors： Vartanian AA,Burova OS,Stepanova EV,Baryshnikov AY,Lichinitser MR

更新日期：2007-12-01 00:00:00

abstract：:In a previous large randomized, open-label study, retrospective subset analysis revealed that the addition of the Bcl-2 antisense oligonucleotide oblimersen to dacarbazine (Dac) significantly improved overall survival, progression-free survival, and the response rate in chemotherapy-naive patients with advanced melano...

journal_title：Melanoma research

authors： Bedikian AY,Garbe C,Conry R,Lebbe C,Grob JJ,Genasense Melanoma Study Group.

更新日期：2014-06-01 00:00:00

abstract：:To examine the distribution of occult micrometastases that could be potential sources of recurrence, complete maps of microscopic and submicroscopic metastases in entire inguinal lymph node basins were generated in 13 melanoma patients who had undergone elective or therapeutic lymphadenectomy. Occult micrometastases w...

journal_title：Melanoma research

authors： Hatta N,Fujimoto A,Takehara K,Takata M

更新日期：1999-08-01 00:00:00

abstract：:In tissue counter analysis, a novel image analysis tool in the evaluation of dermatoscopic images, a lattice of elementary measuring masks (elements) of equal size is randomly placed over the image and the contents of each element is evaluated by a set of colour and texture features. In this study, we tested the effic...

journal_title：Melanoma research

authors： Kahofer P,Hofmann-Wellenhof R,Smolle J

更新日期：2002-02-01 00:00:00

abstract：:Treatment strategies for metastatic melanoma have changed markedly in recent times due to the advent of targeted systemic therapies. In addition to these developments, surgery remains a useful adjunct that can confer survival benefits in selected patients. In this review, we examine the current literature to highlight...

journal_title：Melanoma research

authors： O'Leary DP,Byrnes KG,Power DG,Redmond HP

更新日期：2015-02-01 00:00:00

abstract：:A 58-year-old man with indolent metastatic BRAF mutant melanoma presented with several days' history of progressive ataxia and dysdiadochokinesia. His PET/computed tomography restaging scan indicated two new fluorine-18-fluorodeoxyglucose-avid mesenteric lymph nodes. Meanwhile, his MRI brain and whole spine were withi...

journal_title：Melanoma research

authors： Lee SF,Atkinson V

更新日期：2016-08-01 00:00:00

abstract：:The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in the field of epithelial-mesenchymal transition (EMT). One of these zinc-finger molecules is the transcription factor Snail, which controls gastrulation and neural...

journal_title：Melanoma research

authors： Kuphal S,Palm HG,Poser I,Bosserhoff AK

更新日期：2005-08-01 00:00:00

abstract：:Lymphoscintigraphy (LS) has been performed for 8 years in patients of the Sydney Melanoma Unit, to define lymphatic drainage patterns. Over the past 2 years, LS has also been used to locate the sentinel lymph node prior to surgery. Our technique for LS and subsequent sentinel node biopsy has an accuracy of 97%. All se...

journal_title：Melanoma research

authors： Uren RF,Howman-Giles R,Thompson JF,Shaw HM,Quinn MJ,O'Brien CJ,McCarthy WH

更新日期：1994-12-01 00:00:00

abstract：:Electrochemotherapy (ECT), chemotherapy administered in combination with electric fields, has the potential to be an effective localized treatment for cutaneous malignancies. Bleomycin's cytotoxicity was enhanced by exposing tumour cells to electrical fields following intravenous injection of the chemotherapeutic agen...

journal_title：Melanoma research

authors： Heller R,Jaroszeski M,Perrott R,Messina J,Gilbert R

更新日期：1997-02-01 00:00:00

abstract：:As the cost of air travel has decreased substantially in the USA and Europe over the past few decades, leisure travel to vacation destinations during the winter months has expanded significantly. This trend has probably increased the incidence of significant ultraviolet radiation exposure and sunburn in a broader popu...

journal_title：Melanoma research

authors： Agredano YZ,Chan JL,Kimball RC,Kimball AB

更新日期：2006-02-01 00:00:00

abstract：:Immunotherapy with anti-programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Octogenarians and nonagenarians represent a significant cohort of melanoma patients. This multicenter retrospective analysis enrolled 499 patients treated with nivolumab or pembrolizumab. Seventy-three pati...

journal_title：Melanoma research

authors： Cybulska-Stopa B,Ziętek M,Kamińska-Winciorek G,Czarnecka AM,Piejko K,Galus Ł,Ziółkowska B,Kieszko S,Kempa-Kamińska N,Calik J,Zemełka T,Kubiatowski T,Suwiński R,Mackiewicz J,Rutkowski P

更新日期：2021-02-01 00:00:00