Abstract:
:BRAF mutations are found in ~50% of metastatic melanomas, most commonly in codon V600. Vemurafenib improves progression-free survival and overall survival in patients with advanced BRAF-mutated melanoma. The results of a descriptive study evaluating vemurafenib in patients with advanced melanoma harbouring BRAF mutations other than V600E are reported. Eligible patients with stage IIIC or IV melanoma and non-V600E BRAF mutations received vemurafenib (960 mg, twice daily). End points included investigator-assessed best overall response rate (primary), time to response, duration of response, progression-free survival, overall survival and safety. Planned (V600K vs. non-V600K mutations) subgroup analyses were carried out. Thirty-one patients were enrolled; 13 (42%) had V600K mutations and 18 (58%) had other mutations. Investigator-assessed confirmed that the best overall response rate was 23% (95% confidence interval=10-41%) in the overall population, and was similar between patients with V600K mutations (23%; 95% confidence interval=5-54%) versus other mutations (22%; 95% confidence interval=6-48%). Responses were observed in patients with V600K (n=3), V600E2 (n=1), V600R (n=1), L597S (n=1) and D594G (n=1) mutations. No new safety signals were reported. Vemurafenib showed activity in patients with advanced melanoma with rarer BRAF mutations.
journal_name
Melanoma Resjournal_title
Melanoma researchauthors
Hallmeyer S,Gonzalez R,Lawson DH,Cranmer LD,Linette GP,Puzanov I,Taback B,Cowey CL,Ribas A,Daniels GA,Moore T,Gibney GT,Tawbi H,Whitman E,Lee G,Mun Y,Liu S,Hamid Odoi
10.1097/CMR.0000000000000398subject
Has Abstractpub_date
2017-12-01 00:00:00pages
585-590issue
6eissn
0960-8931issn
1473-5636pii
00008390-201712000-00008journal_volume
27pub_type
杂志文章,多中心研究abstract::Isolated limb perfusion (ILP) with melphalan is used to treat recurrent melanoma. This study aimed to develop a microdialysis technique for melphalan tissue concentration measurement during ILP. The effects of melphalan concentration (50-600 microg/ml), microdIalysis flow rate (0.55-17.5 microl/min), probe length (5-5...
journal_title:Melanoma research
pub_type: 杂志文章
doi:
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journal_title:Melanoma research
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Melanoma research
pub_type: 临床试验,杂志文章
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doi:10.1097/CMR.0b013e32815c10b0
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pub_type: 杂志文章
doi:10.1097/00008390-200304000-00009
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pub_type: 杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e3282fe9a16
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pub_type: 杂志文章
doi:10.1097/00008390-200308000-00003
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pub_type: 杂志文章,评审
doi:10.1097/CMR.0b013e328322fc20
更新日期:2009-04-01 00:00:00
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/CMR.0b013e328303beac
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journal_title:Melanoma research
pub_type: 杂志文章
doi:10.1097/00008390-200012000-00010
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journal_title:Melanoma research
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journal_title:Melanoma research
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doi:10.1097/00008390-199802000-00012
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Melanoma research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1097/CMR.0000000000000112
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journal_title:Melanoma research
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journal_title:Melanoma research
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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