Incorporation of pre-existing collagen bundles in primary cutaneous melanoma.

abstract：:We have observed that an early increase in the CD4+/CD8+ ratio of metastatic melanoma patients during chemoimmunotherapy is the most favourable independent prognostic factor. In this study, 87 patients with metastatic melanoma were monitored for peripheral blood lymphocyte subsets (CD4+ and CD8+) before and during che...

journal_title：Melanoma research

authors： Hernberg MM,Hahka-Kemppinen MH,Pyrhönen SO

更新日期：2004-12-01 00:00:00

abstract：:Metastasis is a complicated multi-step process involving interactions between tumour cells, the extracellular matrix and the vessel walls. Experimental observations suggest that leucocyte migration and function could be a suitable model in order to understand tumour cell dissemination. In the present report we show an...

journal_title：Melanoma research

authors： Bittinger F,González-García JL,Klein CL,Brochhausen C,Offner F,Kirkpatrick CJ

更新日期：1998-10-01 00:00:00

abstract：:The primary treatment of a melanoma is surgical excision. An excisional biopsy is preferred, and safety margins of 1 cm for tumor thickness up to 2 mm and 2 cm for higher tumor thickness should be applied either at primary excision or in a two-step procedure. When dealing with facial, acral or anogenital melanomas, mi...

journal_title：Melanoma research

authors： Garbe C,Hauschild A,Volkenandt M,Schadendorf D,Stolz W,Reinhold U,Kortmann RD,Kettelhack C,Frerich B,Keilholz U,Dummer R,Sebastian G,Tilgen W,Schuler G,Mackensen A,Kaufmann R

更新日期：2008-02-01 00:00:00

abstract：:The objective of this study was to identify novel tumor-suppressor genes in melanoma, using an integrative genomic approach. Data from: (i) earlier reports of DNA loss and gain in malignant melanoma accompanied by comparative genomic hybridization high-definition array data of the entire human genome; (ii) microarray ...

journal_title：Melanoma research

authors： Mithani SK,Smith IM,Califano JA

更新日期：2011-08-01 00:00:00

abstract：:The Eastern Cooperative Oncology Group consensus guidelines from 2016 recommend interruption of targeted therapy with BRAF- and MEK-inhibitors during radiotherapy with data being based mostly on BRAF monotherapy. The aim of this study is to provide data on the safety of concurrent radiotherapy and combination targeted...

journal_title：Melanoma research

authors： Ziegler JS,Kroeze S,Hilbers ML,Imhof L,Guckenberger M,Levesque MP,Dummer R,Cheng P,Mangana J

更新日期：2020-12-01 00:00:00

abstract：:Ipilimumab (anti-CTLA-4 antibody) is a new tool for the treatment of metastatic melanoma patients that has led to an improvement in survival rates worldwide. New types of toxicities have been described with ipilimumab called 'immune-related adverse events' or irAEs. Here, we report an acute and steroid resistant case ...

journal_title：Melanoma research

authors： Pagès C,Gornet JM,Monsel G,Allez M,Bertheau P,Bagot M,Lebbé C,Viguier M

更新日期：2013-06-01 00:00:00

abstract：:The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in the field of epithelial-mesenchymal transition (EMT). One of these zinc-finger molecules is the transcription factor Snail, which controls gastrulation and neural...

journal_title：Melanoma research

authors： Kuphal S,Palm HG,Poser I,Bosserhoff AK

更新日期：2005-08-01 00:00:00

abstract：:Treatment of patients with metastatic uveal melanoma is very challenging because the tumor commonly spreads to the liver, surgical resection of metastases is rarely possible, and there is no standard effective systemic therapy. We report the case of a 38-year-old man, who presented with metastatic involvement of the l...

journal_title：Melanoma research

authors： Kolandjian NA,Patel SP,Papadopoulos NE,Bedikian AY

更新日期：2011-04-01 00:00:00

abstract：:In an attempt to define the role of plasminogen activator in invasiveness and differentiation of human melanoma cells, the modulation of these parameters was studied in two melanoma clones characterized by marked differences in their basal features, using 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and retinoic acid, ...

journal_title：Melanoma research

authors： Supino R,Cecchi C,Mapelli E,Sanfilippo O

更新日期：1994-08-01 00:00:00

abstract：:A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated peptide with a xenogenic peptide (to promote ...

journal_title：Melanoma research

authors： Block MS,Nevala WK,Pang YP,Allred JB,Strand C,Markovic SN

更新日期：2019-08-01 00:00:00

abstract：:In human melanoma no complete information about the expression of the apoptosis-promoting and apoptosis-inhibiting members of the Bcl-2 family has been available to date. In this study we have investigated by Western blotting the expression pattern of Bcl-2 and its homologues Bax, Bak, Bcl-xL, Bcl-xS, Mcl-1 and Bad in...

journal_title：Melanoma research

authors： Selzer E,Schlagbauer-Wadl H,Okamoto I,Pehamberger H,Pötter R,Jansen B

更新日期：1998-06-01 00:00:00

abstract：:Melanocytes are pigmented cells derived from the neural crest; their proliferation is restrained by immune system. The eruption of nevi after an immunosuppressive condition is a peculiar phenomenon indicating that the immune system may play a major role in limiting proliferation of melanocytes. In this review, we anal...

journal_title：Melanoma research

authors： Zattra E,Fortina AB,Bordignon M,Piaserico S,Alaibac M

更新日期：2009-04-01 00:00:00

abstract：:Before licensing, ipilimumab was first made available to previously treated advanced melanoma patients through an expanded access programme (EAP) across Europe. We interrogated data from UK EAP patients to inform future clinical practice. Clinicians registered in the UK EAP provided anonymized patient data using a pre...

journal_title：Melanoma research

authors： Ahmad SS,Qian W,Ellis S,Mason E,Khattak MA,Gupta A,Shaw H,Quinton A,Kovarikova J,Thillai K,Rao A,Board R,Nobes J,Dalgleish A,Grumett S,Maraveyas A,Danson S,Talbot T,Harries M,Marples M,Plummer R,Kumar S,Nathan

更新日期：2015-10-01 00:00:00

abstract：:During the process of melanogenesis free radicals are generated. The aim of this study was to investigate the effects of melanogenesis in B16 melanoma on lipid peroxidation and antioxidant capacity in selected tissues of black C57BL/6J mice. The study was conducted on 24 mice: 12 healthy controls and 12 with a transpl...

journal_title：Melanoma research

authors： Woźniak A,Woźniak B,Drewa G,Drewa T

更新日期：2003-02-01 00:00:00

abstract：:The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro. Up to 50% inhibition of dopachrome formation was observed in the tyrosinase-dopa reaction in the presence of t...

journal_title：Melanoma research

authors： Palumbo A,Mårs U,De Martino L,d'Ischia M,Napolitano A,Larsson BS,Prota G

更新日期：1997-12-01 00:00:00

abstract：:The incidence of melanoma has increased continuously during the last decade. Surgery is the mainstay of therapy but, for patients with thick lesions or regional metastatic lymph nodes, there is a high risk of relapse. For this group of patients, there is no standard therapy or general agreement amongst oncologists. In...

journal_title：Melanoma research

authors： Queirolo P,Acquati M,Kirkwood JM,Eggermont AM,Rocca A,Testori A

更新日期：2005-10-01 00:00:00

abstract：:In metastatic melanoma (MM) immunomodulating agents, such as interleukin-2 (IL-2) and interferon-α (IFN-α), have shown therapeutic benefit as they enhance antitumor immune response. Considering tumor-induced suppression of natural killer (NK) cell activity, it is of interest to study the affect of these cytokines on t...

journal_title：Melanoma research

authors： Konjević G,Mirjačić Martinović K,Vuletić A,Babović N

更新日期：2010-12-01 00:00:00

abstract：:In this study we compared the strength of the association of constitutional factors and sun exposure with cutaneous malignant melanoma (CMM) and basal cell carcinoma (BCC). We analysed 260 incident cases of CMM, 425 incident cases of BCC and two sets of population controls from previous case-control studies conducted ...

journal_title：Melanoma research

authors： Rosso S,Zanetti R,Pippione M,Sancho-Garnier H

更新日期：1998-12-01 00:00:00

abstract：:Cellular senescence is a major barricade on the path of cancer development, yet proteins secreted from senescent cells exert complex and often discordant effects on subsequent cancer evolution. Somatic genome alternations driving the formation of nevi and melanoma are efficient inducers of cellular senescence. Melanoc...

journal_title：Melanoma research

authors： Chavanet A,Hill KR,Jiménez-Andrade Y,Choo MK,White K,Park JM

更新日期：2020-08-01 00:00:00

abstract：:In this study, we aimed to evaluate the feasibility and efficacy of peptide-pulsed dendritic cell (DC) vaccine in combination with carboplatin and paclitaxel chemotherapy (DCCP) for patients with stage IV melanoma previously treated with dacarbazine-containing regimen. Six HLA-A24 and 3 HLA-A02 patients were treated w...

journal_title：Melanoma research

authors： Fukuda K,Funakoshi T,Sakurai T,Nakamura Y,Mori M,Tanese K,Tanikawa A,Taguchi J,Fujita T,Okamoto M,Amagai M,Kawakami Y

更新日期：2017-08-01 00:00:00

abstract：:Malignant melanoma is not only one of the most aggressive and lethal types of neoplasm, but its incidence in the general population is currently increasing at an alarming pace. It is interesting that most melanomas retain many of their characteristics of differentiation, including a dendritic nature and the production...

journal_title：Melanoma research

authors： Tsukamoto K,Gersten DM,Law LW,Hearing VJ

更新日期：1991-11-01 00:00:00

abstract：:In a previous large randomized, open-label study, retrospective subset analysis revealed that the addition of the Bcl-2 antisense oligonucleotide oblimersen to dacarbazine (Dac) significantly improved overall survival, progression-free survival, and the response rate in chemotherapy-naive patients with advanced melano...

journal_title：Melanoma research

authors： Bedikian AY,Garbe C,Conry R,Lebbe C,Grob JJ,Genasense Melanoma Study Group.

更新日期：2014-06-01 00:00:00

abstract：:Conjunctival melanoma is a rare disease, and little is known about its molecular background. Here, we present the case of a 48-year-old patient with conjunctival melanoma and metachronic lymph node and skin metastasis with KRAS p.K117Y mutation in exon 4 in all the lesions. The cancer genome interpreter predicted this...

journal_title：Melanoma research

authors： Del Carpio Huerta LP,Mas Castells M,Anguera Palacios G,Sullivan I,Gonzalez Vidal A,Majem Tarruella M

更新日期：2018-04-01 00:00:00

abstract：:Malignant melanomas usually have an unfavourable prognosis and poor response to chemotherapy. Deregulation of cell proliferation, programmed cell death and intercellular interactions are among several important mechanisms that might lead to malignant transformation of melanocytes and melanoma progression. The S100A1, ...

journal_title：Melanoma research

authors： Sviatoha V,Tani E,Kleina R,Sperga M,Skoog L

更新日期：2010-04-01 00:00:00

abstract：:The treatment of cancer during pregnancy presents a unique challenge. Optimal treatments are often altered or even delayed to protect fetal growth and organogenesis. The landscape of cancer treatment has shifted dramatically over the past several years and treatment with checkpoint inhibitors, including anti-PD1 and a...

journal_title：Melanoma research

authors： Bucheit AD,Hardy JT,Szender JB,Glitza Oliva IC

更新日期：2020-08-01 00:00:00

abstract：:Mucosal melanoma of the nasal cavity and paranasal sinus is always associated with poor prognosis, and 5-year overall survival does not exceed 40%. Our study aimed to compare the intraoperative conditions and prognosis of different surgical techniques to determine the optimum surgical approach for patients with mucosa...

journal_title：Melanoma research

authors： Yin G,Guo W,Chen X,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:Hyperthermic isolated limb perfusion (ILP) with melphalan is well established as an effective form of treatment for recurrent melanoma confined to an extremity. High drug concentrations in the limb are readily achieved, without systemic side-effects. However, regional toxicity can lead to considerable morbidity and fu...

journal_title：Melanoma research

authors： Thompson JF,Eksborg S,Kam PC,Ingvar C,Yau DF,Lai DT,Ramzan I

更新日期：1996-06-01 00:00:00

abstract：:Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B...

journal_title：Melanoma research

authors： Sarubi HC,Pereira NB,Gomes CC,Gomez RS,Carmo ACM,Melo FM,Bastos-Rodrigues L,Pedrosa MS,Friedman E,De Marco L

更新日期：2019-06-01 00:00:00

abstract：:The aim of the study was to identify the frequency of asymptomatic brain metastases detected by computed tomography (CT) scans in patients with metastatic cutaneous melanoma referred to first-line systemic treatment. Between 1995 and 2009, 697 Danish patients were screened with a contrast-enhanced CT scan of the brain...

journal_title：Melanoma research

authors： Zukauskaite R,Schmidt H,Asmussen JT,Hansen O,Bastholt L

更新日期：2013-02-01 00:00:00

abstract：:Despite the general advances in the chemotherapy of malignancies, progress comes slow in the management of patients with disseminated melanoma. Unreflected enthusiasm and frustrated scepticism are the scylla and charybdis between which the physician tries to choose the right way. ...

journal_title：Melanoma research

authors： Kleeberg UR

更新日期：1997-08-01 00:00:00