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Efficacy and safety of prasugrel in acute coronary syndrome patients.

Abstract：

:Ischemic heart disease is the primary cause of death worldwide. The pathophysiological process of cardiovascular diseases is linked to atheromatous plaque formation, while plaque rupture releases thrombogenic elements, which lead to activation of platelets, blood clotting and formation of thrombi. Platelet inhibitors are used to prevent thrombosis. The present systematic review discusses the efficacy of prasugrel in terms of platelet inhibition potential and clinical prevention of cardiovascular outcomes. The balance between reduction of ischemic events as a measure of drug efficacy and the risk of bleeding is reviewed. Other adverse events observed in patients treated with this platelet inhibitor are discussed, including hematological complications, and cutaneous and hepatic idiosyncratic reactions. The complex relationship between prasugrel use and cancer promotion is also described.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Nanau RM,Delzor F,Neuman MG

doi

10.1016/j.clinbiochem.2014.03.005

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

516-28

issue

7-8

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(14)00118-0

journal_volume

47

pub_type

杂志文章,评审

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