Disturbances of calcium and magnesium metabolism occur in most hyperthyroid patients.

abstract：OBJECTIVES:The aim of our study was to examine the influence of atorvastatin on lipid parameters, particularly on HDL, and on the activity of LCAT and CETP and how they affect the activity of the HDL-associated antioxidant enzyme paraoxonase. DESIGN AND METHODS:Thirty-three patients with types II.a and II.b primary hy...

journal_title：Clinical biochemistry

authors： Kassai A,Illyés L,Mirdamadi HZ,Seres I,Kalmár T,Audikovszky M,Paragh G

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To quantitatively summarize the association between tumour necrosis factor alpha (TNF-alpha) gene polymorphisms and Graves' disease. DESIGN AND METHODS:Relevant studies were identified from the following electronic databases: Cochrane Library, MEDLINE, EMBASE and Chinese Bio-medicine Database. A meta-analysi...

journal_title：Clinical biochemistry

authors： Li N,Zhou Z,Liu X,Liu Y,Zhang J,Du L,Wei M,Chen X

更新日期：2008-07-01 00:00:00

abstract：:The current review presents the results of the most recent studies performed on different aspects of human head and neck squamous cell carcinoma, including radiosensitivity induction, efficiency improvement of monoclonal antibodies using low-intensity ultrasound, chemical compounds such as toll-like receptor (TLC) ago...

journal_title：Clinical biochemistry

authors： Safdari Y,Khalili M,Farajnia S,Asgharzadeh M,Yazdani Y,Sadeghi M

更新日期：2014-09-01 00:00:00

abstract：:Three commercially available assays (an enzyme-linked immunosorbent assay ELISA, an immunoradiometric assay, IRMA, and a nephelometric assay) for the determination of lipoprotein(a) [Lp(a)] were compared with respect to the dependency of these assays on the various apolipoprotein(a) [apo(a)] isoforms. Although there w...

journal_title：Clinical biochemistry

authors： Leus FR,Leerink CB,Prins J,van Rijn HJ

更新日期：1994-12-01 00:00:00

abstract：:The use of alcohol and tobacco is prevalent among pregnant women despite the well-known adverse effects of these substances imposed on the developing fetus and immense public health education efforts. Confirmation of gestational exposures to these compounds have relied mostly on maternal self-reporting, which is often...

journal_title：Clinical biochemistry

authors： Chan D,Caprara D,Blanchette P,Klein J,Koren G

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:High levels of intact and cleaved forms of the urokinase-type plasminogen activator receptor (uPAR) in both tissue and blood are associated with poor survival in several cancer diseases. The prognostic significance of uPAR in cholangiocarcinoma is unknown. The aims of this study were to determine if pre-trea...

journal_title：Clinical biochemistry

authors： Grunnet M,Christensen IJ,Lassen U,Jensen LH,Lydolph M,Lund IK,Thurison T,Høyer-Hansen G,Mau-Sørensen M

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:Matrix-assisted laser desorption time-of flight ionization (MALDI)-imaging MS (IMS) with MSMS analysis using on-tissue tryptic digests is a powerful tool for identification of disease-related proteins in formalin-fixed paraffin-embedded (FFPE) tissue sections. We applied this novel IMS technique, not only to...

journal_title：Clinical biochemistry

authors： Nakanishi T,Ito M,Nirasawa T,Tsuji M,Takubo T

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:CA 15-3 and CEA are considered useful tumor markers in monitoring breast cancer patients. This study was undertaken to specifically evaluate the transient elevations in these markers that are observed during systemic treatment for metastatic disease. This phenomenon has been termed "spiking." DESIGN AND MAT...

journal_title：Clinical biochemistry

authors： Yasasever V,Dinçer M,Camlica H,Karaloğlu D,Dalay N

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:Dermatan sulfate (DS) plays a number of roles in a wide range of biological activities such as cell signaling and tissue morphogenesis through interactions with various extracellular matrix proteins including collagen. Mutations in the carbohydrate sulfotransferase 14 gene (CHST14) encoding CHST14/dermatan 4-O-...

journal_title：Clinical biochemistry

authors： Mizumoto S,Kosho T,Hatamochi A,Honda T,Yamaguchi T,Okamoto N,Miyake N,Yamada S,Sugahara K

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:To develop a tandem mass spectrometry (MS/MS) method for plasma free and total carnitine, incorporating acid hydrolysis for total carnitine measurement, for improved accuracy and sample throughput. DESIGN AND METHODS:Limit of detection (LOD), limit of quantitation (LOQ), linearity, accuracy, precision coeff...

journal_title：Clinical biochemistry

authors： Johnson DW

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:In the Olympus uric acid procedure, uric acid is converted by uricase to allantoin and hydrogen peroxide, which is reacted in a Trinder reaction to produce a chromophore read bichromatically at 520 and 660 nm. Repeated difficulty was encountered in obtaining uric acid results on samples from myeloma patien...

journal_title：Clinical biochemistry

authors： Langman LJ,Allen LC,Romaschin AD

更新日期：1998-10-01 00:00:00

abstract：:This review discusses the question: which steps are essential or need to be optimized so that maternal plasma RNA sequencing for pre-eclampsia and related syndromes will become as specific and sensitive as maternal plasma DNA sequencing for trisomy? ...

journal_title：Clinical biochemistry

authors： Oudejans CB

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. DESIGN AND METHODS:The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). RESULTS...

journal_title：Clinical biochemistry

authors： Manukyan GP,Ghazaryan KA,Ktsoyan ZhA,Tatyan MV,Khachatryan ZA,Hakobyan GS,Mkrtchyan VA,Kelly D,Coutts A,Aminov RI

更新日期：2008-07-01 00:00:00

abstract：:The structure of enzyme active sites and the nature of the catalytic process are reviewed. The impressive efficiency of these protein catalysts appears to stem from such factors as proximity and orientation of enzyme and substrate moieties, strain, and the occurrence of distinctive microenvironments within catalytic c...

journal_title：Clinical biochemistry

authors： Blair AH

更新日期：1976-06-01 00:00:00

abstract：OBJECTIVES:[-2]proPSA may discriminate prostate cancer from benign biopsy results. We characterized the pre-analytical stability of [-2]proPSA. DESIGN AND METHODS:22 volunteers, total PSA of 4.5-19.3microg/L, had blood drawn simultaneously. Baseline measurements were performed and samples were stored under various con...

journal_title：Clinical biochemistry

authors： Semjonow A,Köpke T,Eltze E,Pepping-Schefers B,Bürgel H,Darte C

更新日期：2010-07-01 00:00:00

abstract：:Generally acid phosphatase (ACP) assay is used for testing cases of alleged rape. Comparison of three different chemical methods for Acid Phosphatase (Andersch's method with p-nitrophenyl-phosphate substrate and tartrate inhibitor (A-Tart), Roy's method with thymolphthalein phosphate substrate (R-TMP), and Babson's me...

journal_title：Clinical biochemistry

authors： Pragay DA,Casey SJ,Gotthelf J

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:The 6986A>G polymorphism for CYP3A5 and the -129T>C, 1236C>T, 2677G>T/A, and 3435C>T polymorphisms for MDR1 are considered the major genetic factors affecting a range of drugs' metabolism and transport. Simultaneous genotyping of these five polymorphisms would be useful for estimating the therapeutic effects...

journal_title：Clinical biochemistry

authors： Li L,Li CJ,Zhang YJ,Zheng L,Jiang HX,Si-Tu B

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Neonatal abstinence syndrome (NAS) is a rising concern with unknown long-term effects. It is apparent that higher cost of care, impact on the community and reduced quality of life are associated with similar etiologies (e.g., fetal alcohol syndrome). Detection of drug exposure in utero allows for earlier inte...

journal_title：Clinical biochemistry

authors： Labardee RM,Swartzwelder JR,Gebhardt KE,Pardi JA,Dawsey AC,Brent Dixon R,Cotten SW

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Glycosylation analysis provides many opportunities for diagnostics, but its complexity hampers its routine application. Aiming to alleviate this problem, we developed a simple assay that can measure sialylation of transferrin directly from serum. DESIGN AND METHODS:Transferrin samples with different levels ...

journal_title：Clinical biochemistry

authors： Gornik O,Lauc G

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:To compare the circulating levels of cathepsin D in preeclamptic and normotensive pregnancies. DESIGN AND METHODS:Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study. Of the 50 pregnant patients, 15 were preeclamptic and 35 patients were normotensive. Serum levels of soluble cath...

journal_title：Clinical biochemistry

authors： Kim HY,Lee M,Kang HW,Moon C

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To determine pediatric reference values for serum zinc concentration in Iranian subjects. DESIGN AND METHODS:Serum zinc concentration was measured by flame atomic absorption spectrometry in 699 children and adolescents. Reference values for serum zinc were determined according to the Clinical and Laboratory...

journal_title：Clinical biochemistry

authors： Ghasemi A,Zahediasl S,Hosseini-Esfahani F,Syedmoradi L,Azizi F

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To develop a Rapid Flow-through assay for distinguishing replicating Tiantan vaccine-generated serological response from true HIV infection. DESIGN AND METHOD:A Rapid Flow-through Test including gp41, gp36, sk1, sk2 and sk3 antigens was established and the performance of the assay was evaluated in clinical s...

journal_title：Clinical biochemistry

authors： Yuan Z,Chen W,Zhang J,Zhang J,Xiang T,Hu J,Wu Z,Du X,Huang A,Zheng J

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVES:The Golgi SNAP receptor complex member 2 (GOSR2) gene is a Golgi-associated soluble factor attachment receptor (SNARE) protein involved in intra-Golgi protein trafficking on chromosome 17q21, which is the hypertension linkage peak on the human chromosome. The aim of the present study was to assess the associ...

journal_title：Clinical biochemistry

authors： Pan S,Nakayama T,Sato N,Izumi Y,Soma M,Aoi N,Ma Y

更新日期：2013-06-01 00:00:00

abstract：:We compared results of urine drug analysis with clinical data and history to test the usefulness of peripartum drug screening and to establish guidelines for optimal testing. Urine from 28 mothers and 52 babies was analysed. Drugs not suspected by history were found in 10 mothers and six babies. Results assisted in th...

journal_title：Clinical biochemistry

authors： Halstead AC,Godolphin W,Lockitch G,Segal S

更新日期：1988-01-01 00:00:00

abstract：:New methods were developed for the separation of major lipid classes varying in polarity from cholesterol esters to lysophosphatidylcholine. The methods were used for the analysis of extracts obtained from human sera. The lipids were separated by overpressured thin-layer chromatography, classical thin-layer chromatogr...

journal_title：Clinical biochemistry

authors： Pucsok J,Kovács L,Zalka A,Dobó R

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To determine the serum level of fast skeletal troponin I (fsTnl) resulting from skeletal muscle damage, we have developed a sensitive two-site enzyme immunoassay to measure skeletal troponin I. DESIGN AND METHODS:Twelve monoclonal antibodies were raised against human fsTnl. Of these antibodies, 8 were fsTnl-...

journal_title：Clinical biochemistry

authors： Takahashi M,Lee L,Shi Q,Gawad Y,Jackowski G

更新日期：1996-08-01 00:00:00

abstract：:In hepatobiliary disease, the level of bile acids in the peripheral circulation is greatly increased due to impaired liver function. It has been suggested that serum bile acids are of greater value in confirming hepatobiliary dysfunction than the currently assayed conventional biochemical parameters. Fifty patients wi...

journal_title：Clinical biochemistry

authors： Jarzabek JI,Kampa IS

更新日期：1981-12-01 00:00:00

abstract：OBJECTIVES:Hepatic overproduction of apolipoprotein B (apoB)-containing lipoproteins appears to be a common cause of hyperlipoproteinemia in humans. Patients with overproduction states secrete denser cholesterol ester-rich lipoprotein particles which are highly atherogenic. The formation of apoB particles involves a ve...

journal_title：Clinical biochemistry

authors： Adeli K,Mohammadi A,Macri J

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:We investigated the stability of 36 analytes related to clinical chemistry in a controlled storage study. DESIGN AND METHODS:Blood was collected from 11 subjects and was maintained for 45 min, 2.5 h, 5 h, or 24 h after phlebotomy before centrifugation. RESULTS:Statistically significant changes were observe...

journal_title：Clinical biochemistry

authors： Zwart SR,Wolf M,Rogers A,Rodgers S,Gillman PL,Hitchcox K,Ericson KL,Smith SM

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility of detecting circulating cancer cells in peripheral blood from gastric cancer patients using Piwi-interacting RNAs (piRNAs) as markers. DESIGN AND METHODS:Real-time quantitative reverse transcription-polymerase chain reaction was used to analyze piR-651 and piR-823 levels in th...

journal_title：Clinical biochemistry

authors： Cui L,Lou Y,Zhang X,Zhou H,Deng H,Song H,Yu X,Xiao B,Wang W,Guo J

更新日期：2011-09-01 00:00:00