Inhibiting replication of begomoviruses using artificial zinc finger nucleases that target viral-conserved nucleotide motif.

abstract：:Cauliflower mosaic virus (CaMV) gene I encodes a protein (P1) that has been implicated in the control of virus movement in infected plants. To assist in the characterization of the mechanism of action of P1, gene I has been expressed efficiently in Spodoptera frugiperda (Sf) cells using recombinant baculovirus. Contro...

journal_title：Virus genes

authors： Maule AJ,Usmany M,Wilson IG,Boudazin G,Vlak JM

更新日期：1992-01-01 00:00:00

abstract：:Cap-independent translations of viral RNAs of enteroviruses and rhinoviruses, cardioviruses and aphthoviruses, hepatitis A and C viruses (HAV and HCV), and pestivirus are initiated by the direct binding of 40S ribosomal subunits to a cis-acting genetic element termed the internal ribosome entry site (IRES) or ribosome...

journal_title：Virus genes

authors： Le SY,Siddiqui A,Maizel JV Jr

更新日期：1996-01-01 00:00:00

abstract：:Cytotoxic T cells that recognize dengue fever viral (DFV) peptides were reported. To predict the cleavage pattern of DFV proteins by cytoplasmic proteasomes into nonapeptides with motifs fitting known HLA class I molecules, the computer program "Findpatterns" was used. In this study the combined amino acid motifs for ...

journal_title：Virus genes

authors： Becker Y

更新日期：1995-01-01 00:00:00

abstract：:White spot syndrome virus (WSSV) is one of the most virulent pathogens causing high mortality in shrimp. The viral early genes play a key role in DNA replication and virus proliferation. In this study, a WSSV gene (wsv477) encoding 208 amino acid peptides was characterized as an early gene. The temporal analysis showe...

journal_title：Virus genes

authors： Han F,Xu J,Zhang X

更新日期：2007-04-01 00:00:00

abstract：:Base usage and dinucleotide frequency have been extensively studied in many eukaryotic organisms and bacteria, but not for viruses. In this paper, a comprehensive analysis of these aspects for infectious bursal disease virus (IBDV) was presented. The analysis of base usage indicated that all of the IBDV genes possess ...

journal_title：Virus genes

authors： Tan DY,Hair Bejo M,Aini I,Omar AR,Goh YM

更新日期：2004-01-01 00:00:00

abstract：:The eight gene segments of avian influenza virus (AIV) reassort frequently and rapidly to generate novel genotypes and subtypes that are transmissible to a broad range of hosts. There is evidence that AIV can have a restricted host range and can segregate in space and time. Host-virus relationships at the species, geo...

journal_title：Virus genes

authors： Girard YA,Runstadler JA,Aldehoff F,Boyce W

更新日期：2012-06-01 00:00:00

abstract：:The complete nucleotide sequence of rice tungro spherical virus (RTSV) strain Vt6, originally from Mindanao, the Philippines, with higher virulence to resistant rice cultivars, was determined and compared with the published sequence for the Philippine-type strain A (RTSV-A-Shen). It was reported that RTSV-A was not ab...

journal_title：Virus genes

authors： Isogai M,Cabauatan PQ,Masuta C,Uyeda I,Azzam O

更新日期：2000-01-01 00:00:00

abstract：:Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. The present study aimed to identify the specific gene mutation related to the clinical outcome of HCC. Seventy-two HBV-infecte...

journal_title：Virus genes

authors： Fan W,Shi B,Wei H,Du G,Song S

更新日期：2011-04-01 00:00:00

abstract：:We amplified the capsid protein gene fragments of 30 Japanese isolates of feline calicivirus (FCV), including the C, D, and E regions, by reverse transcription-polymerase chain reaction (RT-PCR), followed by direct sequencing. Alignment of the predicted amino acid sequences, together with other published sequences fro...

journal_title：Virus genes

authors： Horimoto T,Takeda Y,Iwatsuki-Horimoto K,Sugii S,Tajima T

更新日期：2001-01-01 00:00:00

abstract：:The genomic structure of two strains of orf virus (OV), a field isolate (MRI-Scab) which has never been passaged in cell culture, and a multiple-passage cell culture-adapted strain (Orf-11) were compared. The Orf-11 genome is approximately 8.0 kb longer than that of the MRI-Scab due to a duplication of the right-hand ...

journal_title：Virus genes

authors： McInnes CJ,Wood AR,Nettleton PE,Gilray JA

更新日期：2001-03-01 00:00:00

abstract：:Protein 2A is a non-structural protein of coxsackievirus B3 (CVB3), an important human pathogen that can cause a variety of human diseases. Protein 2A not only participates in viral life cycle, but also regulates host cell functions; however, the underlying mechanisms remain poorly understood. In order to better under...

journal_title：Virus genes

authors： Zhao T,Huang X,Xia Y

更新日期：2016-04-01 00:00:00

abstract：:The VP2 gene DNA (1.4 kb in approximate) of a very virulent infectious bursal disease virus (vvIBDV) Chinju strain detected in Chinju, Korea was cloned into the bacmid, a baculovirus shuttle vector, through transposition of the gene from initially cloned pFastBacHTa plasmid, a baculovirus expression vector, and was su...

journal_title：Virus genes

authors： Kim TK,Yeo SG

更新日期：2003-08-01 00:00:00

abstract：:The authentic major capsid protein 1 (VP1) of hamster polyomavirus (HaPyV) consists of 384 amino acid (aa) residues (42 kDa). Expression from an additional in-frame initiation codon located upstream from the authentic VP1 open reading frame (at position -4) might result in the synthesis of a 388 aa-long, amino-termina...

journal_title：Virus genes

authors： Voronkova T,Kazaks A,Ose V,Ozel M,Scherneck S,Pumpens P,Ulrich R

更新日期：2007-06-01 00:00:00

abstract：:Avian reovirus infection causes considerable economic loss to the commercial poultry industry. Live-attenuated vaccine strain S1133 (v-S1133, derived from parent strain S1133) is considered the safest and most effective vaccine and is currently used worldwide. To identify the genes responsible for its attenuation, DNA...

journal_title：Virus genes

authors： Teng L,Xie Z,Xie L,Liu J,Pang Y,Deng X,Xie Z,Fan Q,Luo S,Feng J,Khan MI

更新日期：2014-04-01 00:00:00

abstract：:Macropodid herpesvirus 1 (MaHV-1) is an unclassified alphaherpesvirus linked with the fatal infections of kangaroos and other marsupials. During the characterisation of the internal repeat region of MaHV-1, an open reading frame (ORF) encoding for thymidylate synthase (TS) gene was identified and completely sequenced....

journal_title：Virus genes

authors： Guliani S,Polkinghorne I,Smith GA,Young P,Mattick JS,Mahony TJ

更新日期：2002-06-01 00:00:00

abstract：:Coxsackieviruses are important human pathogens that induce myocarditis and pancreatitis. However, there are no vaccines or therapeutic reagents for their clinical treatment. Although RNA interference (RNAi)-based approaches to the prevention of viral production have been developed recently, limitations to the in vivo ...

journal_title：Virus genes

authors： Kim YJ,Ahn J,Jeung SY,Kim DS,Na HN,Cho YJ,Yun SH,Jee Y,Jeon ES,Lee H,Nam JH

更新日期：2008-02-01 00:00:00

abstract：:The genomes (188 kbp) of the prototype Molluscum contagiosum virus type 1 (MCV-1) and a variant strain (MCV-1v) were characterized by construction of the physical maps of the viral DNA for the restriction enzymes BamHI, ClaI, EcoRI, and HindIII using a defined gene library harboring the DNA sequences of the MCV-1 geno...

journal_title：Virus genes

authors： Bugert J,Rösen-Wolff A,Darai G

更新日期：1989-11-01 00:00:00

abstract：:Recently, NADC30-like porcine reproductive and respiratory syndrome viruses (PRRSVs), which are genetically similar to the NADC30 strain isolated in the United States of America in 2008, have become prevalent in China. Here, a novel variant PRRSV strain named HNhx was successfully isolated on porcine alveolar macropha...

journal_title：Virus genes

authors： Wang LJ,Wan B,Guo Z,Qiao S,Li R,Xie S,Chen XX,Zhang G

更新日期：2018-02-01 00:00:00

abstract：:Fourteen infectious bronchitis viruses (IBVs) were isolated in Korea between 2001 and 2003 from chickens suspected to be infected with IBVs. The nucleocapsid (N) protein genes of the various IBVs were amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) and were cloned and sequenced, and the nucleotid...

journal_title：Virus genes

authors： Park JY,Pak SI,Sung HW,Kim JH,Song CS,Lee CW,Kwon HM

更新日期：2005-10-01 00:00:00

abstract：:By using a phage vector (lambda ZAP II) and the mRNA extracted from IMR-32 cells infected with the RC.HL strain of rabies virus, we constructed a cDNA library from which four nucleoprotein (N)-specific cDNA clones were obtained by Southern blot hybridization. These clones contained a cDNA insert of about 1.4 kb, in wh...

journal_title：Virus genes

authors： Goto H,Minamoto N,Ito H,Sugiyama M,Kinjo T,Mannen K,Mifune K,Kawai A

更新日期：1994-03-01 00:00:00

abstract：:Cotton leaf curl disease (CLCuD) has been a major constraint to cotton production across Pakistan and northwestern India since the early 1990s. The disease is caused by a number of begomoviruses, including Cotton leaf curl Multan virus (CLCuMuV), which associate with a specific host range and symptom determining betas...

journal_title：Virus genes

authors： Masood M,Briddon RW

更新日期：2018-12-01 00:00:00

abstract：:A bovine viral diarrhea disease virus (BVDV) GS-4 was isolated in Western China form dairy cattle with respiratory disease. Genomic comparison analysis with the 5' half genome sequence encompassing the coding region of N(pro), capsid, and envelope glycoproteins showed that the GS-4 should be classified into BVDV-1b1, ...

journal_title：Virus genes

authors： Gao S,Shao J,Du J,Lin T,Cong G,Zhao F,Chang H,Yin H

更新日期：2013-08-01 00:00:00

abstract：:The broad distribution and prevalence of H3 subtype influenza viruses in avian and mammalian hosts constitutes a global threat to both human and veterinary health. In this present study, six H3N8 influenza viruses isolated from domestic ducks during 2004-2005 in northern China were genetically and phylogenetically cha...

journal_title：Virus genes

authors： Pu J,Liu QF,Xia YJ,Fan YL,Brown EG,Tian FL,Liu JH

更新日期：2009-02-01 00:00:00

abstract：:N20-RNA 3L, a large form of RNA 3 associated with Alfalfa mosaic virus (AMV) strain N20 comprises 2281 nt and has approximately 97% overall sequence similarity to the longest previously described RNA 3 of AMV strain YSMV (YSMV-RNA 3; 2188 nt). Compared with YSMV-RNA 3, N20-RNA 3L contains an additional 97 nt in the 5'...

journal_title：Virus genes

authors： Jayasena KW,Randles JW

更新日期：2004-12-01 00:00:00

abstract：:Pandemic H1N1 2009 (pH1N1), influenza virus containing triple reassortant internal genes (TRIG) from avian, human, and swine influenza viruses emerged in 2009 as a highly infectious virus that was able to be transmitted from humans to pigs. During June 2010-May 2012, influenza virus surveillance was conducted in Thai ...

journal_title：Virus genes

authors： Charoenvisal N,Keawcharoen J,Sreta D,Chaiyawong S,Nonthabenjawan N,Tantawet S,Jittimanee S,Arunorat J,Amonsin A,Thanawongnuwech R

更新日期：2013-08-01 00:00:00

abstract：:The incidence of watermelon chlorotic stunt disease and the molecular characterization of the Jordanian isolate of Watermelon chlorotic stunt virus (WmCSV-[JO]) are described in this study. Symptomatic leaf samples obtained from watermelon (Citrullus lanatus Thunb.), melon (Cucumis melo L.), squash (Cucurbita pepo), c...

journal_title：Virus genes

authors： Al-Musa A,Anfoka G,Al-Abdulat A,Misbeh S,Haj Ahmed F,Otri I

更新日期：2011-08-01 00:00:00

abstract：:In this study, we report the discovery and molecular characterization of a novel mycovirus, Nigrospora oryzae fusarivirus 1 (NoFV1) isolated from the rice-infecting fungus Nigrospora oryzae. Excluding a poly (A) tail, the genome of the virus is 7004 nucleotide (nt) long containing three putative nonoverlapping open re...

journal_title：Virus genes

authors： Zhong J,Zhao SQ,Li GF,Pang XD,Deng XJ,Zhu HJ,Da Gao B,Zhou Q

更新日期：2016-12-01 00:00:00

abstract：:Hepatitis E virus (HEV) has emerged as an important cause of epidemic and sporadic acute viral hepatitis worldwide, which is a major public health challenge. A better understanding of the interaction between the virus and the host cell would be very helpful for its therapy. Swine HEV (SHEV) open reading frame 3 (ORF3)...

journal_title：Virus genes

authors： Cheng Y,Du L,Shi Q,Jiao H,Zhang X,Hao Y,Rong H,Zhang J,Jia X,Guo S,Kuang W,Zhang H,Chen C,Wang F

更新日期：2013-08-01 00:00:00

abstract：:Emerging pseudorabies virus (PRV) variant has led to frequent outbreaks of PRV infection among Bartha-K61-vaccinated swine population in Chinese swine farms and caused high mortality in pigs of all age since late 2011. Here, we generated a gE/gI-deleted PRV (rPRVXJ-delgI/gE-EGFP) based on PRV variant strain (PRV-XJ) t...

journal_title：Virus genes

authors： Yin Y,Xu Z,Liu X,Li P,Yang F,Zhao J,Fan Y,Sun X,Zhu L

更新日期：2017-08-01 00:00:00

abstract：:The intraspecies variability of capsid proteins of five viruses of the genus Comovirus was established. Inclusion of both capsid proteins to the sequence analysis reduces some uncertainties about species/strains demarcation criteria in the Comovirus genus. New approach is proposed for discrimination of Turnip ringspot...

journal_title：Virus genes

authors： Petrzik K,Koloniuk I

更新日期：2010-04-01 00:00:00